Results 71 to 80 of about 14,670 (186)

PLXNA1 variants and oligogenicity in Kallmann syndrome: Expanding the semaphorin–neuropilin–plexin pathway

Journal of Advanced Biotechnology and Experimental Therapeutics
A rare genetic condition, Kallmann syndrome (KS), causes congenital hypogonadotropic hypogonadism (CHH) and anosmia, resulting from impaired migration of gonadotropin-releasing hormone (GnRH) neurons.
Anastasha Faustine, Tri Indah Winarni, Agustini Utari   +2 more
doaj   +1 more source

Thiazolidinediones enhance vascular endothelial growth factor expression and induce cell growth inhibition in non-small-cell lung cancer cells

Journal of Experimental & Clinical Cancer Research, 2010
Background It is known that thiazolidinediones are involved in regulating the expression of various genes, including the vascular endothelial growth factor (VEGF) gene via peroxisome proliferator-activated receptor γ (PPARγ); VEGF is a prognostic ...
Yoshizaki Yumiko, Kumei Shima, Tanno Sachie, Motomura Wataru, Yoshizaki Takayuki, Tanno Satoshi, Okumura Toshikatsu   +6 more
doaj   +1 more source

In‐Vitro Evaluation of HIV/SARS‐CoV‐2 Co‐Infection Mediated Proteomic Changes in Astrocytes and Pericytes Reveals Altered Signaling Pathways Associated With Neurodegenerative Disorders

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT Coronavirus disease 2019 (COVID‐19) survivors frequently experience a wide range of symptoms known as post‐acute sequelae of SARS‐CoV‐2 (PASC) or long COVID. Importantly, complications arising from microvascular dysfunction, blood‐brain barrier (BBB) disruption, and chronic neuroinflammation have been implicated in driving PASC within the ...
Arpan Acharya, Michellie Thurman, Debapriya Sutar, Oluwatayo Israel Olasunkanmi, Johid R. Malik, Shetty Ravi Dyavar, Ákos Végvári, Siddappa N. Byrareddy   +7 more
wiley   +1 more source

Lymphatic Endothelial Cells in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang, Wang Lin, Hengyang Liu, Jixin Zhong, Shiliang Li, Xiaoquan Rao   +5 more
wiley   +1 more source

Proteomic and Phosphoproteomic Characteristics of Multiple Brain Regions in Rhesus Macaques After SARS‐CoV‐2 Infection

MedComm, Volume 7, Issue 8, August 2026.
The study found that SARS‐CoV‐2 Omicron infection causes region‐specific inflammatory, immune, synaptic, and signaling disorders in the brain, and the predicted kinases and differentially expressed proteins may serve as potential targets for COVID‐19‐related drug discovery.
Qiaochu Wang, Yanan Zhou, Tao Ding, Yan Sun, Yehong Yang, Yue Wu, Jiangfeng Liu, Shuaiyao Lu, Juntao Yang   +8 more
wiley   +1 more source

A noncanonical role for Jagged1 in endothelial mechanotransduction

The FEBS Journal, Volume 293, Issue 15, Page 4604-4623, August 2026.
The Notch signaling pathway plays a crucial role in regulating endothelial biology. Notch signaling is sensitive to hemodynamic forces and governs mechanically driven cardiovascular development, physiology, and remodeling. This study reveals a non‐canonical role for the Notch ligand Jagged1 in endothelial mechanotransduction.
Freddy Suarez Rodriguez, Noora Virtanen, Elmeri Kiviluoto, Rob C. H. Driessen, Feihu Zhao, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren   +7 more
wiley   +1 more source

Salivary Neuropilin-1 as a Promising Biomarker in Smokers with and without Oral Leukoplakia and Oral Cancer Patients: A Clinico-Biochemical Study

Journal of Indian Academy of Oral Medicine and Radiology
Background: Neuropilin-1 (NRP1) is a transmembrane glycoprotein which has a pivotal role in pathological processes of cancer progression and metastasis.
Deepasakthi Jayagopi, Sreedevi Dharman, Selvaraj Jayaraman   +2 more
doaj   +1 more source

Enhancement of Circulating and Intestinal T Regulatory Cells and Their Expression of Helios and Neuropilin-1 in Children with Inflammatory Bowel Disease

Journal of Inflammation Research, 2020
Katarzyna Sznurkowska,1 Justyna Luty,2 Ewa Bryl,2 Jacek M Witkowski,3 Blanka Hermann-Okoniewska,4 Piotr Landowski,1 Marta Kosek,1 Agnieszka Szlagatys-Sidorkiewicz1 1Department of Pediatrics, Pediatric Gastroenterology, Allergology and Nutrition, Medical ...
Sznurkowska K, Luty J, Bryl E, Witkowski JM, Hermann-Okoniewska B, Landowski P, Kosek M, Szlagatys-Sidorkiewicz A   +7 more
doaj  

Expression of Semaphorin 3F and Its Receptors in Epithelial Ovarian Cancer, Fallopian Tubes, and Secondary Müllerian Tissues

Obstetrics and Gynecology International, 2009
While semaphorins and their receptors appear to play a role in tumor carcinogenesis, little is known about the role of semaphorin 3F (S3F) in epithelial ovarian cancer (EOC) development. Therefore, we sought to determine the clinical relationship between
Christina D. Drenberg, Sandra Livingston, Ren Chen, Patricia A. Kruk, Santo V. Nicosia   +4 more
doaj   +1 more source

Human neuropilin-1 biomarker as predictor of subclinical cardiovascular affection in systemic lupus erythematosus patients

Egyptian Rheumatology and Rehabilitation
Background Cardiovascular disease (CVD) is recognized as the leading cause of death in patients with systemic lupus erythematosus (SLE). Although the pathways involved in accelerated cardiovascular disease are not yet fully understood, atherogenesis may ...
Samar Gaber Soliman, Samah Samy Yossef, Shaimaa R. Shahin, Dina Mamdoh Serag, Dalia S. Saif   +4 more
doaj   +1 more source