Results 1 to 10 of about 14,499 (138)
Differential expression of viral entry protein neuropilin 1 (NRP1) and neuropilin 2 (NRP2) in fatal COVID-19 [PDF]
Journal of VirologyCoronavirus disease 2019 (COVID-19) is associated with hyperinflammation, endothelialitis, hypoxemia, and hypercoagulation, contributing to thrombosis in acute severe and long COVID. While ACE2 is the primary severe acute respiratory syndrome coronavirus
A. Dette +11 more
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Neuropilin-1: A Multifaceted Target for Cancer Therapy [PDF]
Current OncologyNeuropilin-1 (NRP1), initially identified as a neuronal guidance protein, has emerged as a multifaceted regulator in cancer biology. Beyond its role in axonal guidance and angiogenesis, NRP1 is increasingly recognized for its significant impact on tumor ...
Sai Manasa Varanasi +4 more
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Non-Coding RNA, 2021 Neuropilin-1 is a transmembrane glycoprotein that has been implicated in several processes including angiogenesis and immunity. Recent evidence has also shown that it is implied in the cellular internalization of the severe acute respiratory syndrome ...
Pasquale Mone +5 more
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Neuropilin 1 Regulation of Vascular Permeability Signaling
Biomolecules, 2021 The vascular endothelium acts as a selective barrier to regulate macromolecule exchange between the blood and tissues. However, the integrity of the endothelium barrier is compromised in an array of pathological settings, including ischemic disease and ...
Alison Domingues, Alessandro Fantin
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Targeting neuropilin-1 to inhibit VEGF signaling in cancer: Comparison of therapeutic approaches. [PDF]
PLoS Computational Biology, 2006 Angiogenesis (neovascularization) plays a crucial role in a variety of physiological and pathological conditions including cancer, cardiovascular disease, and wound healing.
Feilim Mac Gabhann, Aleksander S Popel
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Neuropilin 1 Involvement in Choroidal and Retinal Neovascularisation. [PDF]
PLoS ONE, 2017 PURPOSE:Inhibiting VEGF is the gold standard treatment for neovascular age-related macular degeneration (AMD). It is also effective in preventing retinal oedema and neovascularisation (NV) in diabetic retinopathy (DR) and retinal vein occlusions (RVO ...
Patricia Fernández-Robredo +4 more
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Upregulation of Neuropilin-1 Inhibits HTLV-1 Infection
Pathogens, 2023 Infection with human T-cell leukemia virus type 1 (HTLV-1) can produce a spectrum of pathological effects ranging from inflammatory disorders to leukemia. In vivo, HTLV-1 predominantly infects CD4+ T-cells.
Wesley Kendle +5 more
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Hepatology, EarlyView., 2022 Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid +20 more
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Pharmaceutics, 2023 The combination of a tumor-penetrating peptide (TPP) with a peptide able to interfere with a given protein–protein interaction (IP) is a promising strategy with potential clinical application.
Gustavo H. Marin +6 more
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Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea. [PDF]
PLoS Genetics, 2017 Neuropilin-1 (Nrp1) encodes the transmembrane cellular receptor neuropilin-1, which is associated with cardiovascular and neuronal development and was within the peak SNP interval on chromosome 8 in our prior GWAS study on age-related hearing loss (ARHL)
Pezhman Salehi +15 more
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