Results 31 to 40 of about 14,577 (178)

Neuropilin-1 and Integrins as Receptors for Chromogranin A-Derived Peptides

Pharmaceutics, 2022
Human chromogranin A (CgA), a 439 residue-long member of the “granin” secretory protein family, is the precursor of several peptides and polypeptides involved in the regulation of the innate immunity, cardiovascular system, metabolism, angiogenesis ...
Angelo Corti, Giulia Anderluzzi, Flavio Curnis   +2 more
doaj   +1 more source

Expression and regulation of neuropilin-1 in human astrocytomas [PDF]

International Journal of Cancer, 2000
Vascular endothelial growth factor (VEGF), through activation of its endothelial receptors VEGFR-1 and VEGFR-2, is an important positive modulator of tumor angiogenesis and edema in solid tumors such as malignant astrocytomas. Neuropilin-1 (Npn-1) is a transmembrane receptor expressed by both endothelial and non-endothelial cells, including tumor cells.
H, Ding, X, Wu, L, Roncari, N, Lau, P, Shannon, A, Nagy, A, Guha   +6 more
openaire   +2 more sources

Novel Small-Molecule Inhibitors of the SARS-CoV-2 Spike Protein Binding to Neuropilin 1

Pharmaceuticals, 2022
Furin cleavage of the SARS-CoV-2 spike protein results in a polybasic terminal sequence termed the C-end rule (CendR), which is responsible for the binding to neuropilin 1 (NRP1), enhancing viral infectivity and entry into the cell.
Anja Kolarič, Marko Jukič, Urban Bren
doaj   +1 more source

Neuropilin‐1 is not a marker of human Foxp3⁺ Treg [PDF]

European Journal of Immunology, 2009
AbstractTreg are immune cells that play a critical role in the regulation of the immune response. Although the transcription factor Foxp3 is widely accepted as the standard marker of Treg, specific surface markers are needed to better characterize these cells and decipher their mechanisms of action.
Milpied, Pierre, Renand, Amédée, Bruneau, Julie, Mendes-da-Cruz, Daniella A, Jacquelin, Sébastien, Asnafi, Vahid, Rubio, Marie-Thérèse, MacIntyre, Elizabeth, Lepelletier, Yves, Hermine, Olivier   +9 more
openaire   +4 more sources

Neuropilin-1 biases dendrite polarization in the retina [PDF]

Development, 2013
The majority of neurons in the nervous system exhibit a polarized morphology, with multiple short dendrites and a single long axon. It is clear that multiple factors govern polarization in developing neurons, and the biased accumulation of intrinsic determinants to one side of the cell, coupled with responses to asymmetrically localized extrinsic ...
Elizabeth M, Kita, Gabriel E, Bertolesi, Carrie L, Hehr, Jillian, Johnston, Sarah, McFarlane   +4 more
openaire   +2 more sources

Interacting Proteins, Polymorphisms and the Susceptibility of Animals to SARS-CoV-2

Animals, 2021
COVID-19, caused by SARS-CoV-2, is a world-wide problem for the human population. It is known that some animal species, such as mink, can become infected and transmit the virus. However, the susceptibility of most animals is not known.
John T. Hancock, Ros C. Rouse, Emma Stone, Alexander Greenhough   +3 more
doaj   +1 more source

Dorsal turning of motor corticospinal axons at the pyramidal decussation requires plexin signaling

Neural Development, 2008
Background The development of the corticospinal tract (CST) in higher vertebrates relies on a series of axon guidance decisions along its long projection pathway.
Coble Jeffrey, Liu Xiao-Bo, Low Lawrence K, Faulkner Regina L, Jones Edward G, Cheng Hwai-Jong   +5 more
doaj   +1 more source

Role of Semaphorin 3A in Kidney Development and Diseases

Diagnostics, 2023
Kidney diseases are worldwide public health problems affecting millions of people. However, there are still limited therapeutic options against kidney diseases. Semaphorin 3A (SEMA3A) is a secreted and membrane-associated protein, which regulates diverse
Yizhen Sang, Kenji Tsuji, Hiroyuki Nakanoh, Kazuhiko Fukushima, Shinji Kitamura, Jun Wada   +5 more
doaj   +1 more source

Deconstruction of Human Age‐Related Cataract Capsules Defines Aging

Advanced Science, EarlyView.
We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang, Ziyang Tong, Chunmei Fan, Silong Chen, Jiarui Guo, Jianghua Hu, Ke Yao, Zi Yin, Xiao Chen, Yibo Yu   +9 more
wiley   +1 more source

Neuropilin-1 Suppresses Tumorigenic Properties in a Human Pancreatic Adenocarcinoma Cell Line Lacking Neuropilin-1 Coreceptors [PDF]

Cancer Research, 2005
Abstract Neuropilin-1 (NRP-1) was first described as a coreceptor implicated in neuronal guidance that bound members of the semaphorin/collapsin family. NRP-1 is also expressed in endothelial cells and is believed to promote angiogenesis by acting as a coreceptor with vascular endothelial growth factor (VEGF) receptor 2.
Michael J, Gray, Jane S, Wey, Anna, Belcheva, Marya F, McCarty, Jose G, Trevino, Douglas B, Evans, Lee M, Ellis, Gary E, Gallick   +7 more
openaire   +2 more sources