Results 41 to 50 of about 14,577 (178)

Sonoselective Transfection of Glioma Endothelium

Advanced Science, EarlyView.
Delivering non‐viral, gene‐bearing nanoparticles with thiol‐decorated surfaces to gliomas with focused ultrasound yields transfection tropism for endothelial cells. From this platform, “sonoselective” transfection of glioma endothelium is achieved via incorporation of an endothelial cell‐specific promoter.
Anna C. Debski, Catherine M. Gorick, Victoria R. Breza, Jackson Tirrell, Krishan Perumal, Katherine M. Nowak, Ji Song, Natasha D. Sheybani, Richard J. Price   +8 more
wiley   +1 more source

Targeting neuropilin-1 in human leukemia and lymphoma

Blood, 2011
Abstract Targeted drug delivery offers an opportunity for the development of safer and more effective therapies for the treatment of cancer. In this study, we sought to identify short, cell-internalizing peptide ligands that could serve as directive agents for specific drug delivery in hematologic malignancies.
Katja, Karjalainen, Diana E, Jaalouk, Carlos E, Bueso-Ramos, Amado J, Zurita, Akihiko, Kuniyasu, Bedrich L, Eckhardt, Frank C, Marini, Benjamin, Lichtiger, Susan, O'Brien, Hagop M, Kantarjian, Jorge E, Cortes, Erkki, Koivunen, Wadih, Arap, Renata, Pasqualini   +13 more
openaire   +3 more sources

Neuropilin-1–Dependent Regulation of EGF-Receptor Signaling [PDF]

Cancer Research, 2012
Abstract Neuropilin-1 (NRP1) is a coreceptor for multiple extracellular ligands. NRP1 is widely expressed in cancer cells and in advanced human tumors; however, its functional relevance and signaling mechanisms are unclear. Here, we show that NRP1 expression controls viability and proliferation of different cancer cells, independent ...
Rizzolio, Sabrina, Rabinowicz, Noa, Rainero, Elena, Lanzetti, Letizia, Serini, Guido, Norman, Jim, Neufeld, Gera, Tamagnone, Luca   +7 more
openaire   +3 more sources

Expression of Semaphorin 3A and Neuropilin 1 in Asthma

Journal of Korean Medical Science, 2013
Neuropilin 1 (NP1) is a part of essential receptor complexes mediating both semaphorin3A (SEMA3A) and vascular endothelial growth factor (VEGF) which is one of important mediators involved in the pathogenesis of asthma. Therefore, it is possible that SEMA3A plays a role in the pathogenesis of asthma through attenuation of VEGF-mediated effects.
Shim, Eun-Jin, Chun, Eunyoung, Kang, Hae-Ryun, Cho, Sang-Heon, Min, Kyung-Up, Park, Heung-Woo   +5 more
openaire   +2 more sources

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Neuropilin Antagonists (NRPas) Block the Phosphorylation of the Cancer Therapeutic Key Factor p38α Kinase Triggering Cell Death

Molecules
Neuropilin-1 is henceforth a relevant target in cancer treatment; however, its way of action remains partly elusive, and the development of small inhibitory molecules is therefore required for its study.
Lucia Borriello, Rafika Jarray, Rachel Rignault-Bricard, Matthieu Montes, Nicolas Lopez, Thiago Trovati Maciel, Olivier Hermine, Françoise Raynaud, Luc Demange, Yves Lepelletier   +9 more
doaj   +1 more source

Goofy/123Cre lineage tracing differentiates olfactory and vomeronasal neurons from GnRH‐1 and terminal nerve neurons during neuronal migration and reveals additional olfactory placode‐derived cells in the brain

Developmental Dynamics, EarlyView.
Abstract The olfactory placode (OP) generates a broad array of chemosensory neurons in the nasal region, including olfactory sensory neurons, vomeronasal sensory neurons, neurons of the septal organ, and Grueneberg ganglion. During invagination, the OP also generates migratory neuronal populations, including gonadotropin‐releasing hormone‐1 (GnRH‐1 ...
Enrico Amato Jr., Mia V. Call, Noah M. LeFever, Mya Aviles‐Carlos, Nikki M. Dolphin, Paolo E. Forni   +5 more
wiley   +1 more source

Neuropilin-1 drives tumor-specific uptake of chlorotoxin

Cell Communication and Signaling, 2019
Background Chlorotoxin (Cltx) isolated from scorpion venom is an established tumor targeting and antiangiogenic peptide. Radiolabeled Cltx therapeutic (131I-TM601) yielded promising results in human glioma clinical studies, and the imaging agent ...
Sharon McGonigle, Utpal Majumder, Donna Kolber-Simonds, Jiayi Wu, Andrew Hart, Thomas Noland, Karen TenDyke, Daniel Custar, Danyang Li, Hong Du, Maarten H. D. Postema, W. George Lai, Natalie C. Twine, Mary Woodall-Jappe, Kenichi Nomoto   +14 more
doaj   +1 more source

Architecture and hydration of the arginine‐binding site of neuropilin‐1 [PDF]

The FEBS Journal, 2018
Neuropilin‐1 (NRP1) is a transmembrane co‐receptor involved in binding interactions with variety of ligands and receptors, including receptor tyrosine kinases. Expression of NRP1 in several cancers correlates with cancer stages and poor prognosis.
Mota, F, Fotinou, C, Rhana, R, Edith Chan, AW, Yelland, T, Arooz, MT, O'Leary, AP, Hutton, J, Frankel, P, Zachary, I, Selwood, D, Djordjevic, S   +11 more
openaire   +4 more sources

Systemically Administered, Target-Specific, Multi-Functional Therapeutic Recombinant Proteins in Regenerative Medicine

Nanomaterials, 2020
Growth factors, chemokines and cytokines guide tissue regeneration after injuries. However, their applications as recombinant proteins are almost non-existent due to the difficulty of maintaining their bioactivity in the protease-rich milieu of injured ...
Tero A.H. Järvinen, Toini Pemmari
doaj   +1 more source