Results 41 to 50 of about 21,250,288 (213)

Targeting neuropilin-1 to inhibit prostate cancer invasion and metastasis

, 2015
Recent reports provide evidence\ud that the epithelial-to-mesenchymal\ud transition (EMT) plays a key role in prostate\ud cancer (PCa) metastasis and therapy\ud resistance.
McGowan, Kayla, Williams, Elizabeth D., Lehman, Melanie, Tse, Brian W.C., Stylianou, Nataly, Nelson, Colleen, Costa, Taylor, Volpert, Marianna, Hollier, Brett G., Ratther, Ellca, Gleave, Martin, Fazli, Ladan, McPherson, Stephen, Russell, Pamela, Gunter, Jennifer H.   +14 more
core   +2 more sources

Neuropilin-1 Suppresses Tumorigenic Properties in a Human Pancreatic Adenocarcinoma Cell Line Lacking Neuropilin-1 Coreceptors [PDF]

Cancer Research, 2005
Abstract Neuropilin-1 (NRP-1) was first described as a coreceptor implicated in neuronal guidance that bound members of the semaphorin/collapsin family. NRP-1 is also expressed in endothelial cells and is believed to promote angiogenesis by acting as a coreceptor with vascular endothelial growth factor (VEGF) receptor 2.
Michael J, Gray, Jane S, Wey, Anna, Belcheva, Marya F, McCarty, Jose G, Trevino, Douglas B, Evans, Lee M, Ellis, Gary E, Gallick   +7 more
openaire   +2 more sources

Dorsal turning of motor corticospinal axons at the pyramidal decussation requires plexin signaling

Neural Development, 2008
Background The development of the corticospinal tract (CST) in higher vertebrates relies on a series of axon guidance decisions along its long projection pathway.
Coble Jeffrey, Liu Xiao-Bo, Low Lawrence K, Faulkner Regina L, Jones Edward G, Cheng Hwai-Jong   +5 more
doaj   +1 more source

Conservation and Enhanced Binding of SARS-CoV-2 Omicron Spike Protein to Coreceptor Neuropilin-1 Predicted by Docking Analysis

Infectious Disease Reports, 2022
The Omicron variant of SARS-CoV-2 bears peptide sequence alterations that correlate with a higher infectivity than was observed in the original SARS-CoV-2 isolated from Wuhan, China.
Piyush Baindara, Dinata Roy, Santi M. Mandal, Adam G. Schrum   +3 more
doaj   +1 more source

Neuropilin-mediated neural crest cell guidance is essential to organise sensory neurons into segmented dorsal root ganglia

, 2009
The peripheral nervous system (PNS) of higher vertebrates is segmented to align the spinal nerve roots with the vertebrae. This co-patterning is set up during embryogenesis, when vertebrae develop from the sclerotome layer of the metameric somites, and ...
Maden, CH, Christiana Ruhrberg, Quenten Schwarz, Davidson, K., Schwarz, Q, Ruhrberg, C., Kathryn Davidson, Maden, C., Davidson, K, Ruhrberg, C, Schwarz, Q., Charlotte H. Maden   +11 more
core   +1 more source

Targeting neuropilin-1 in human leukemia and lymphoma

Blood, 2011
Abstract Targeted drug delivery offers an opportunity for the development of safer and more effective therapies for the treatment of cancer. In this study, we sought to identify short, cell-internalizing peptide ligands that could serve as directive agents for specific drug delivery in hematologic malignancies.
Katja, Karjalainen, Diana E, Jaalouk, Carlos E, Bueso-Ramos, Amado J, Zurita, Akihiko, Kuniyasu, Bedrich L, Eckhardt, Frank C, Marini, Benjamin, Lichtiger, Susan, O'Brien, Hagop M, Kantarjian, Jorge E, Cortes, Erkki, Koivunen, Wadih, Arap, Renata, Pasqualini   +13 more
openaire   +3 more sources

In Silico and In Vitro Studies of Alchemilla viridiflora Rothm—Polyphenols’ Potential for Inhibition of SARS-CoV-2 Internalization

Molecules, 2022
Since the outbreak of the COVID-19 pandemic, it has been obvious that virus infection poses a serious threat to human health on a global scale. Certain plants, particularly those rich in polyphenols, have been found to be effective antiviral agents.
Relja Suručić, Jelena Radović Selgrad, Tatjana Kundaković-Vasović, Biljana Lazović, Maja Travar, Ljiljana Suručić, Ranko Škrbić   +6 more
doaj   +1 more source

Activation of the aryl hydrocarbon receptor inhibits neuropilin-1 upregulation on IL-2-responding CD4+ T cells

Frontiers in Immunology, 2023
Neuropilin-1 (Nrp1), a transmembrane protein expressed on CD4+ T cells, is mostly studied in the context of regulatory T cell (Treg) function. More recently, there is increasing evidence that Nrp1 is also highly expressed on activated effector T cells ...
Simone Sandoval, Keegan Malany, Krista Thongphanh, Clarisa A. Martinez, Michael L. Goodson, Felipe Da Costa Souza, Lo-Wei Lin, Nicolle Sweeney, Jamie Pennington, Pamela J. Lein, Nancy I. Kerkvliet, Allison K. Ehrlich   +11 more
doaj   +1 more source

Expression of Semaphorin 3A and Neuropilin 1 in Asthma

Journal of Korean Medical Science, 2013
Neuropilin 1 (NP1) is a part of essential receptor complexes mediating both semaphorin3A (SEMA3A) and vascular endothelial growth factor (VEGF) which is one of important mediators involved in the pathogenesis of asthma. Therefore, it is possible that SEMA3A plays a role in the pathogenesis of asthma through attenuation of VEGF-mediated effects.
Shim, Eun-Jin, Chun, Eunyoung, Kang, Hae-Ryun, Cho, Sang-Heon, Min, Kyung-Up, Park, Heung-Woo   +5 more
openaire   +2 more sources

Neuropilin-1–Dependent Regulation of EGF-Receptor Signaling [PDF]

Cancer Research, 2012
Abstract Neuropilin-1 (NRP1) is a coreceptor for multiple extracellular ligands. NRP1 is widely expressed in cancer cells and in advanced human tumors; however, its functional relevance and signaling mechanisms are unclear. Here, we show that NRP1 expression controls viability and proliferation of different cancer cells, independent ...
Rizzolio, Sabrina, Rabinowicz, Noa, Rainero, Elena, Lanzetti, Letizia, Serini, Guido, Norman, Jim, Neufeld, Gera, Tamagnone, Luca   +7 more
openaire   +3 more sources