Results 61 to 70 of about 21,250,288 (213)

Alteration of Neuropilin-1 and Heparan Sulfate Interaction Impairs Murine B16 Tumor Growth. [PDF]

ACS Chem Biol
Neuropilin-1 acts as a coreceptor with vascular endothelial growth factor receptors to facilitate binding of its ligand, vascular endothelial growth factor.
Painter CD, Sankaranarayanan NV, Nagarajan B, Mandel Clausen T, West AMV, Setiawan NJ, Park J, Porell RN, Bartels PL, Sandoval DR, Vasquez GJ, Chute JP, Godula K, Vander Kooi CW, Gordts PLSM, Corbett KD, Termini CM, Desai UR, Esko JD.   +18 more
europepmc   +2 more sources

Novel Small-Molecule Inhibitors of the SARS-CoV-2 Spike Protein Binding to Neuropilin 1

Pharmaceuticals, 2022
Furin cleavage of the SARS-CoV-2 spike protein results in a polybasic terminal sequence termed the C-end rule (CendR), which is responsible for the binding to neuropilin 1 (NRP1), enhancing viral infectivity and entry into the cell.
Anja Kolarič, Marko Jukič, Urban Bren
doaj   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient mortality

, 2017
Neuropilin-1 is upregulated in the adaptive response of prostate tumors to androgen-targeted therapies and is prognostic of metastatic progression and patient ...
CC Nelson (15837548), PA Gregory (9884105), ML Lehman (15837554), BWC Tse (21766265), N Stylianou (17225392), L Fazli (16151672), ME Gleave (16151678), M Alshalafa (21794423), M Nouri (16307301), LA Selth (9884249), BG Hollier (21767279), PJ Russell (21690305), M Roshan-Moniri (21794411), J McGovern (13508143), ED Williams (9893567), N Erho (21794420), EM Schaeffer (21794426), MS Butler (15858779), J Caradec (21794414), JH Gunter (21782885), CY Gregory-Evans (15968843), M Takhar (21794417), R Buttyan (21782879), E Davicioni (16218146), E Ratther (21767276), K McGowan (7613696), SJ McPherson (21794408), PS Rennie (21794429), RB Den (21782936), AE Ross (21782933), R Das (12148338), RJ Karnes (16218143), M Volpert (21794405), RB Jenkins (16174535)   +33 more
core   +1 more source

Neuropilin-1 drives tumor-specific uptake of chlorotoxin

Cell Communication and Signaling, 2019
Background Chlorotoxin (Cltx) isolated from scorpion venom is an established tumor targeting and antiangiogenic peptide. Radiolabeled Cltx therapeutic (131I-TM601) yielded promising results in human glioma clinical studies, and the imaging agent ...
Sharon McGonigle, Utpal Majumder, Donna Kolber-Simonds, Jiayi Wu, Andrew Hart, Thomas Noland, Karen TenDyke, Daniel Custar, Danyang Li, Hong Du, Maarten H. D. Postema, W. George Lai, Natalie C. Twine, Mary Woodall-Jappe, Kenichi Nomoto   +14 more
doaj   +1 more source

Peptide‐directed nanovehicles enabling tumor‐selective ROS amplification and antitumor immunity

VIEW, EarlyView.
Cancer cells are vulnerable to oxidative stress, yet exploit immune tolerance to escape destruction. In contrast, their metabolic profile is markedly altered to support rapid proliferation, accompanied by elevated production of reactive oxygen species (ROS).
Manuela Calin, Galyna Bila, Ileana Manduteanu, Rostyslav Bilyy   +3 more
wiley   +1 more source

Expression of neuropilin-1 in CFU-Fs.

, 2013
A: Immunohistochemistry for Neuropilin-1 expression in irradiated mice CFU-Fs (magnification ×200). B: Evolution of neuropilin-1 mRNAs in in vitro-irradiated CFU-Fs.
Chantal Humblet (332380), Kimimitsu Oda (332384), Marie-Paule Defresne (332386), Géraldine Poncin (332378), Aurore Beaulieu (332379), Jacques Boniver (91763), Albert Thiry (332382)   +6 more
core   +1 more source

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, EarlyView.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source

Neuropilin-1 attenuates autoreactivity in experimental autoimmune encephalomyelitis [PDF]

Proceedings of the National Academy of Sciences, 2011
Neuropilin-1 ( Nrp1 ) is a cell surface molecule originally identified for its role in neuronal development. Recently, Nrp1 has been implicated in several aspects of immune function including maintenance of the immune synapse and development of regulatory T (T reg ...
Benjamin D, Solomon, Cynthia, Mueller, Wook-Jin, Chae, Leah M, Alabanza, Margaret S, Bynoe   +4 more
openaire   +2 more sources

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source