Role of NRP1 in Bladder Cancer Pathogenesis and Progression
Frontiers in Oncology, 2021 Bladder urothelial carcinoma (BC) is a fatal invasive malignancy and the most common malignancy of the urinary system. In the current study, we investigated the function and mechanisms of Neuropilin-1 (NRP1), the co-receptor for vascular endothelial ...
Wei-Ming Ma +2 more
exaly +3 more sources
Crosstalk between NRP1 and autophagy in the tumor microenvironment: from molecular mechanisms to therapeutic targeting [PDF]
Frontiers in ImmunologyNeuropilin-1 (NRP1) is overexpressed in various malignant solid tumors, modulating the tumor microenvironment (TME) via multiple mechanisms to promote immune suppression, angiogenesis, and epithelial-mesenchymal transition (EMT), ultimately resulting in ...
You Wang +8 more
doaj +2 more sources
Multi-Omics and Machine Learning Integration Identifies Key Endothelial Modules in Carotid Artery Stenosis. [PDF]
J Clin Lab AnalThis study integrates multi‐omics data (single‐cell RNA‐seq, bulk RNA‐seq, and proteomics) from carotid artery plaques to identify novel biomarkers for diagnosing stenosis. Through a computational pipeline involving cell population analysis, WGCNA, and machine learning models, we identified and validated NRP1 and XAF1 as key endothelial biomarkers ...
Wu J +5 more
europepmc +2 more sources
Targeting neuropilin-1 and neutralizing interleukin-6 inhibits cancer stem cell formation in bladder cancer cells [PDF]
Journal of Translational MedicineBackground Bladder urothelial carcinoma (BLCA) remains a clinical challenge because of its high recurrence rate and the persistence of cancer stem cells (CSCs) within the tumor microenvironment (TME).
Hsiao-Wen Weng +5 more
doaj +2 more sources
Molecular Genetics & Genomic Medicine, 2021 Background Isolated hypogonadotropic hypogonadism (IHH) is a clinical syndrome described by failure of gonadal function secondary to defects on the synthesis, secretion, or action of the gonadotropin‐releasing hormone (GnRH).
Meichao Men, Dan-Na Chen, Jia-Da Li
exaly +2 more sources
miRNA-145/miRNA-205 inhibits proliferation and invasion of uveal melanoma cells by targeting NPR1/CDC42 [PDF]
International Journal of Ophthalmology, 2020 AIM: To investigate the role of microRNA-145 (miRNA-145) and microRNA-205 (miRNA-205) in proliferation and invasion of uveal melanoma (UM) cells. METHODS: The expression level of miRNA-145 and miRNA-205 from samples of UM patients were determined by ...
Yang Li +3 more
doaj +1 more source
Frontiers in Immunology, 2023 Neuropilin-1 (Nrp1), a transmembrane protein expressed on CD4+ T cells, is mostly studied in the context of regulatory T cell (Treg) function. More recently, there is increasing evidence that Nrp1 is also highly expressed on activated effector T cells ...
Simone Sandoval +11 more
doaj +1 more source
Targeting neuropilin-1 interactions is a promising anti-tumor strategy
Chinese Medical Journal, 2021 . Neuropilins (NRP1 and NRP2) are multifunctional receptor proteins that are involved in nerve, blood vessel, and tumor development. NRP1 was first found to be expressed in neurons, but subsequent studies have demonstrated its surface expression in cells
Shao-Dan Liu +4 more
doaj +1 more source
A Novel Physiological Glycosaminoglycan-Deficient Splice Variant of Neuropilin-1 Is Anti-Tumorigenic In Vitro and In Vivo. [PDF]
PLoS ONE, 2016 Neuropilin-1 (NRP1) is a transmembrane protein acting as a co-receptor for several growth factors and interacting with other proteins such as integrins and plexins/semaphorins.
Céline Hendricks +5 more
doaj +1 more source
Histone Chaperone Nrp1 Mutation Affects the Acetylation of H3K56 in Tetrahymena thermophila
Cells, 2022 Histone modification and nucleosome assembly are mainly regulated by various histone-modifying enzymes and chaperones. The roles of histone-modification enzymes have been well analyzed, but the molecular mechanism of histone chaperones in histone ...
Yinjie Lian +4 more
doaj +1 more source