Results 21 to 30 of about 15,068 (213)

Effects of MLL5 and HOXA regulated by NRP1 on radioresistance in A549

Oncology Letters, 2021
Radiotherapy is widely used in the management of lung cancer, and physicians are aware that the effect of radiotherapy is dependent on radiosensitivity. Although a series of blockers and activators targeting molecules related to radioresistance have been developed as radiation sensitizers, compensatory mechanisms or drug resistance limits their ...
Shao, Lihong, Zhang, Yuyu, Gong, Xinkou, Dong, Zhuo, Wei, Wei, Sun, Hongyan, Sun, Ran, Cong, Lele, Cong, Xianling, Jin, Shunzi   +9 more
openaire   +3 more sources

NRP1 promotes prostate cancer progression via modulating EGFR-dependent AKT pathway activation

Cell Death and Disease, 2023
Prostate cancer (PCa) is the most common malignant tumor with a high global incidence in males. The mechanism underlying PCa progression is still not clear.
Peng Zhang, Liang Chen, Fenfang Zhou, Zhiwen He, Gang Wang, Yongwen Luo   +5 more
doaj   +1 more source

An Essential NRP1-Mediated Role for Tagln2 in Gastric Cancer Angiogenesis [PDF]

Frontiers in Oncology, 2021
Knowledge about the precise biological role and underlying mechanism of Tagln2 in tumor progression is relatively limited, especially in angiogenesis focused on tumor derived endothelial cells (ECs) has rarely been reported. Here, the function, molecular mechanism and potential clinical value of Tagln2 in gastric cancer (GC) angiogenesis were ...
Hongwei Jin, Wei Zheng, Wei Zheng, Jingjing Hou, Jingjing Hou, Huifang Peng, Huiqin Zhuo, Huiqin Zhuo   +7 more
openaire   +3 more sources

Neuropilin-1 is over-expressed in claudin-low breast cancer and promotes tumor progression through acquisition of stem cell characteristics and RAS/MAPK pathway activation

Breast Cancer Research, 2022
Background Triple-negative breast cancers (TNBC) have a relatively poor prognosis and responses to targeted therapies. Between 25 and 39% of TNBCs are claudin-low, a poorly differentiated subtype enriched for mesenchymal, stem cell and mitogen-activated ...
Yu Hin Tang, Anja Rockstroh, Kamil A. Sokolowski, Layla-Rose Lynam, Melanie Lehman, Erik W. Thompson, Philip A. Gregory, Colleen C. Nelson, Marianna Volpert, Brett G. Hollier   +9 more
doaj   +1 more source

HNF4G accelerates glioma progression by facilitating NRP1 transcription

Oncology Letters, 2023
Hepatocyte nuclear factor 4γ (HNF4G) is considered to be a transcription factor and functions as an oncogene in certain types of human cancer. However, the precise functions and the potential molecular mechanisms of HNF4G in glioma remain unclear. Therefore, the present study aimed to elucidate the role of HNF4G in glioma and the underlying mechanism ...
Che, Hongmin, Zheng, Qi, Liao, Zijun, Zhang, Lu   +3 more
openaire   +2 more sources

MicroRNA-338 inhibits growth, invasion and metastasis of gastric cancer by targeting NRP1 expression. [PDF]

PLoS ONE, 2014
NRP1 as multifunctional non-tyrosine-kinase receptors play critical roles in tumor progression. MicroRNAs (miRNAs) are an important class of pervasive genes that are involved in a variety of biological functions, particularly cancer.
Yang Peng, Yan-Min Liu, Lu-Chun Li, Lu-Lu Wang, Xiao-Ling Wu   +4 more
doaj   +1 more source

Role of Nrp1 in controlling cortical inter-hemispheric circuits

eLife, 2022
Axons of the corpus callosum (CC) mediate the interhemispheric communication required for complex perception in mammals. In the somatosensory (SS) cortex, the CC exchanges inputs processed by the primary (S1) and secondary (S2) areas, which receive tactile and pain stimuli. During early postnatal life, a multistep process involving
Fernando Martín-Fernández, Ana Bermejo-Santos, Lorena Bragg-Gonzalo, Carlos G Briz, Esther Serrano-Saiz, Marta Nieto   +5 more
openaire   +4 more sources

Neuropilin-1 Is Expressed on Lymphoid Tissue Residing LTi-like Group 3 Innate Lymphoid Cells and Associated with Ectopic Lymphoid Aggregates

Cell Reports, 2017
Here, we characterize a subset of ILC3s that express Neuropilin1 (NRP1) and are present in lymphoid tissues, but not in the peripheral blood or skin. NRP1+ group 3 innate lymphoid cells (ILC3s) display in vitro lymphoid tissue inducer (LTi) activity.
Medya Mara Shikhagaie, Åsa K. Björklund, Jenny Mjösberg, Jonas S. Erjefält, Anne S. Cornelissen, Xavier Romero Ros, Suzanne M. Bal, Jasper J. Koning, Reina E. Mebius, Michiko Mori, Melanie Bruchard, Bianca Blom, Hergen Spits   +12 more
doaj   +1 more source

Epidermal expression of neuropilin 1 protects murine keratinocytes from UVB-induced apoptosis. [PDF]

PLoS ONE, 2012
BACKGROUND: Neuropilin 1 (NRP1) is expressed on several cell types including neurons and endothelial cells, where it functions as an important regulator in development and during angiogenesis.
Anna Riese, Yvonne Eilert, Yvonne Meyer, Meral Arin, Jens M Baron, Sabine Eming, Thomas Krieg, Peter Kurschat   +7 more
doaj   +1 more source

Role of Nrp1 in controlling cortical interhemispheric circuits [PDF]

, 2021
Abstract Callosal projections establish topographically organized maps between cortical areas. Neuropilin-1 (Nrp1) cortical gradient induces an early segregation of developing callosal axons. We investigated later roles of Nrp1 on the development of callosal projections from layer (L) 2/3 of the primary (S1) and ...
F Martín-Fernández, C. G. Briz, M. Nieto   +2 more
openaire   +1 more source