Results 1 to 10 of about 14,527 (137)
Neuropilin 1 Regulation of Vascular Permeability Signaling
Biomolecules, 2021 The vascular endothelium acts as a selective barrier to regulate macromolecule exchange between the blood and tissues. However, the integrity of the endothelium barrier is compromised in an array of pathological settings, including ischemic disease and ...
Alessandro Fantin, Fantin Alessandro
exaly +3 more sources
Differential expression of viral entry protein neuropilin 1 (NRP1) and neuropilin 2 (NRP2) in fatal COVID-19 [PDF]
Journal of VirologyCoronavirus disease 2019 (COVID-19) is associated with hyperinflammation, endothelialitis, hypoxemia, and hypercoagulation, contributing to thrombosis in acute severe and long COVID. While ACE2 is the primary severe acute respiratory syndrome coronavirus
A. Dette +11 more
doaj +2 more sources
Upregulation of Neuropilin-1 Inhibits HTLV-1 Infection [PDF]
Pathogens, 2023 Infection with human T-cell leukemia virus type 1 (HTLV-1) can produce a spectrum of pathological effects ranging from inflammatory disorders to leukemia. In vivo, HTLV-1 predominantly infects CD4+ T-cells.
Wesley Kendle +5 more
doaj +2 more sources
Role of Neuropilin 1 in COVID-19 Patients with Acute Ischemic Stroke
Biomedicines, 2022 Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection can trigger the adaptive and innate immune responses, leading to uncontrolled inflammatory reactions and associated local and systematic tissue damage, along with thromboembolic ...
Ali I Al-Gareeb +2 more
exaly +3 more sources
Neuropilin-1: A Multifaceted Target for Cancer Therapy [PDF]
Current OncologyNeuropilin-1 (NRP1), initially identified as a neuronal guidance protein, has emerged as a multifaceted regulator in cancer biology. Beyond its role in axonal guidance and angiogenesis, NRP1 is increasingly recognized for its significant impact on tumor ...
Sai Manasa Varanasi +4 more
doaj +2 more sources
Non-Coding RNA, 2021 Neuropilin-1 is a transmembrane glycoprotein that has been implicated in several processes including angiogenesis and immunity. Recent evidence has also shown that it is implied in the cellular internalization of the severe acute respiratory syndrome ...
Pasquale Mone +5 more
doaj +1 more source
Targeting neuropilin-1 to inhibit VEGF signaling in cancer: Comparison of therapeutic approaches. [PDF]
PLoS Computational Biology, 2006 Angiogenesis (neovascularization) plays a crucial role in a variety of physiological and pathological conditions including cancer, cardiovascular disease, and wound healing.
Feilim Mac Gabhann, Aleksander S Popel
doaj +1 more source
Neuropilin 1 Involvement in Choroidal and Retinal Neovascularisation. [PDF]
PLoS ONE, 2017 PURPOSE:Inhibiting VEGF is the gold standard treatment for neovascular age-related macular degeneration (AMD). It is also effective in preventing retinal oedema and neovascularisation (NV) in diabetic retinopathy (DR) and retinal vein occlusions (RVO ...
Patricia Fernández-Robredo +4 more
doaj +1 more source
Obesity Facts, 2021 Introduction: Neuropilin 1 (NRP-1) is a novel co-receptor promoting SARS-CoV-2 infectivity. Animal data indicate a role in trans-endothelial lipid transport and storage. As human data are sparse, we aimed to assess the role of NRP-1 in 2 metabolic active
Dominik Soll +5 more
doaj +1 more source
Hepatology, EarlyView., 2022 Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid +20 more
wiley +1 more source