Results 21 to 30 of about 14,577 (176)
Role of Nrp1 in controlling cortical inter-hemispheric circuits
eLife, 2022 Axons of the corpus callosum (CC) mediate the interhemispheric communication required for complex perception in mammals. In the somatosensory (SS) cortex, the CC exchanges inputs processed by the primary (S1) and secondary (S2) areas, which receive ...
Fernando Martín-Fernández +5 more
doaj +1 more source
Role of Neuropilin-1 in Diabetic Nephropathy [PDF]
Journal of Clinical Medicine, 2015 Diabetic nephropathy (DN) often develops in patients suffering from type 1 or type 2 diabetes mellitus. DN is characterized by renal injury resulting in proteinuria. Neuropilin-1 (NRP-1) is a single-pass transmembrane receptor protein devoid of enzymatic activity.
Bondeva, Tzvetanka, Wolf, Gunter
openaire +2 more sources
Pharmaceutics, 2023 The combination of a tumor-penetrating peptide (TPP) with a peptide able to interfere with a given protein–protein interaction (IP) is a promising strategy with potential clinical application.
Gustavo H. Marin +6 more
doaj +1 more source
Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins
Mechanisms of Development, 2001 Neuropilin-1 (np1) and neuropilin-2 (np2) are receptors for class-3 semaphorins and for several isoforms of VEGF. We have cloned and characterized two chick isoforms of np2 cDNA. Expression patterns of np1, np2, and ephrin-B2 were compared in the developing vascular system of 24-72 h old chick embryos.
Herzog, Yael +4 more
openaire +2 more sources
Neuropilin-1 Participates in Wound Angiogenesis [PDF]
The American Journal of Pathology, 2002 Angiogenesis, the formation of new capillaries from existing vasculature, plays an essential role in tissue repair. The rapid onset and predominance of proangiogenic factors optimizes healing in damaged tissues. One factor that directly mediates wound vessel angiogenesis is vascular endothelial growth factor (VEGF).
Annette M, Matthies +3 more
openaire +2 more sources
Significance of Neuropilin-1 Expression in Acute Myeloid Leukemia
Turkish Journal of Hematology, 2013 Objective: Neuropilin-1 is a vascular endothelial growth factor receptor that acts as a mediator of angiogenesis. Its importance in hematological malignancies such as acute myeloid leukemia (AML) remains to be elucidated.
Tarif H. Sallam +3 more
doaj +1 more source
Neuropilin-1 Regulates the Secondary CD8 T Cell Response to Virus Infection
mSphere, 2019 Neuropilin-1 (Nrp1) plays important roles in axonal guidance in neurons and in the growth of new blood vessels. There is also a growing appreciation for roles played by neuropilin-1 in the immune response.
Ji Young Hwang +3 more
doaj +1 more source
MiR-200c sensitizes Olaparib-resistant ovarian cancer cells by targeting Neuropilin 1
Journal of Experimental & Clinical Cancer Research, 2020 Background Ovarian cancer (OC) is the most lethal gynecological malignancy and the second leading cause of cancer-related death in women. Treatment with PARP inhibitors (PARPi), such as Olaparib, has been recently introduced for OC patients, but ...
Enrica Vescarelli +15 more
doaj +1 more source
New Biosensor for Determination of Neuropilin-1 with Detection by Surface Plasmon Resonance Imaging
Sensors, 2023 Neuropilin-1 is transmembrane protein with soluble isoforms. It plays a pivotal role in both physiological and pathological processes. NRP-1 is involved in the immune response, formation of neuronal circuits, angiogenesis, survival and migration of cells.
Anna Sankiewicz +4 more
doaj +1 more source
Chemoenzymatic Synthesis of Well‐Defined α(2,8)‐ and α(2,9)‐Linked Oligosialosides
Angewandte Chemie, EarlyView.Well‐defined α(2,8)‐ and α(2,9)‐linked oligosialic acids of different lengths can be prepared by employing recombinant bacterial polysialyltransferases in combination with chemically modified CMP‐Neu5Ac derivatives. After transfer, a sialoside is formed bearing an artificial entity, which blocks further glycosylation.
Jelle A. Fok +4 more
wiley +2 more sources