Results 31 to 40 of about 14,577 (176)
Nrp1 is Activated by Konjac Ceramide Binding-Induced Structural Rigidification of the a1a2 Domain
Cells, 2020 Konjac ceramide (kCer) is a plant-type ceramide composed of various long-chain bases and α-hydroxyl fatty acids. The presence of d4t,8t-sphingadienine is essential for semaphorin 3A (Sema3A)-like activity. Herein, we examined the three neuropilin 1 (
Seigo Usuki +11 more
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Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection
Molecular Medicine, 2021 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because of it, it is ...
Svetlana P. Chapoval, Achsah D. Keegan
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Nature Communications, 2019 O-glycosylation of neuropilin-1 is involved in cancer migration and invasion. Here, the authors show that defects in N-glycosylation of two neuropilin-1 splice variants enhance the co-internalisation of Met, it’s interaction with β1-integrin, and ...
Xiuping Huang +10 more
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Journal of Experimental & Clinical Cancer Research, 2021 Background Despite the improvement of relapse-free survival mediated by anti-angiogenic drugs like sunitinib (Sutent®), or by combinations of anti-angiogenic drugs with immunotherapy, metastatic clear cell Renal Cell Carcinoma (mccRCC) remain incurable ...
Aurore Dumond +14 more
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Neuropilin 1: A Novel Entry Factor for SARS-CoV-2 Infection and a Potential Therapeutic Target
Biologics: Targets & Therapy, 2021 Endeshaw Chekol Abebe,1 Teklie Mengie Ayele,2 Zelalem Tilahun Muche,3 Tadesse Asmamaw Dejenie4 1Department of Medical Biochemistry, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; 2Department of Pharmacy, College of Health ...
Chekol Abebe E +3 more
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Expression of Placental Growth Factor, Neuropilin-1 and Neuropilin-2 in Primary Pterygium Tissue
Graefe's Archive for Clinical and Experimental Ophthalmology, 2022 Abstract Objective The aim of this study was to evaluate the expression of Placental Growth Factor (PLGF), Neuropilin-1 (NP-1) and Neuropilin-2 (NP-2) molecules in the primary pterygium tissue compared with the normal conjunctival tissue. Methods The records of 42 patients who underwent excision surgery with autograft for primary pterygium ...
Ali Osman Gundogan +3 more
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Frontiers in Immunology, 2019 Optimizing Treg function and improving Treg stability are attractive treatment strategies for treating autoimmune rheumatoid arthritis (RA). However, the limited number of circulating Tregs and questions about the functional stability of in vitro ...
Min-Jung Park +16 more
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Epidermal expression of neuropilin 1 protects murine keratinocytes from UVB-induced apoptosis. [PDF]
PLoS ONE, 2012 BACKGROUND: Neuropilin 1 (NRP1) is expressed on several cell types including neurons and endothelial cells, where it functions as an important regulator in development and during angiogenesis.
Anna Riese +7 more
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Journal of Oral Biology and Craniofacial Research, 2021 Background: Soluble Neuropilin-1 (sNRP-1) is a glycoprotein with angiogenic and immune regulatory functions, which correspond to processes deeply involved with periodontal diseases.
Diego Prieto +5 more
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Identification of circulating neuropilin-1 and dose-dependent elevation following anti-neuropilin-1 antibody administration [PDF]
mAbs, 2009 Neuropilin-1 (NRP1) acts as a co-receptor for class 3 semaphorins and vascular endothelial growth factor and is an attractive angiogenesis target for cancer therapy. In addition to the transmembrane form, naturally occurring soluble NRP1 proteins containing part of the extracellular domain have been identified in tissues and a cell line.
Yanmei, Lu +9 more
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