Results 11 to 20 of about 14,577 (176)

Neuropilin-1 in Transplantation Tolerance [PDF]

Frontiers in Immunology, 2013
In the immune system, Neuropilin-1 (Nrp1) is a molecule that plays an important role in establishing the immunological synapse between dendritic cells (DCs) and T cells.
Mauricio eCampos-Mora, Rodrigo A Morales, Tania eGajardo, Diego eCatalan, Karina ePino-Lagos   +4 more
doaj   +4 more sources

The role of Neuropilin-1 in COVID-19.

PLoS Pathogens, 2021
Neuropilin-1 (NRP-1), a member of a family of signaling proteins, was shown to serve as an entry factor and potentiate SARS Coronavirus 2 (SARS-CoV-2) infectivity in vitro.
Bindu S Mayi, Jillian A Leibowitz, Arden T Woods, Katherine A Ammon, Alphonse E Liu, Aarti Raja   +5 more
doaj   +5 more sources

Neuropilin-1 as therapeutic target for malignant melanoma [PDF]

Frontiers in Oncology, 2015
Neuropilin-1 (NRP-1) is a transmembrane glycoprotein that acts as a co-receptor for various members of the VEGF family. Its ability to bind or modulate the activity of a number of other extracellular ligands, such as class 3 semaphorins, TGF-β, HGF, FGF ...
Grazia eGraziani, Pedro M Lacal
doaj   +4 more sources

Endothelial VEGFR Coreceptors Neuropilin-1 and Neuropilin-2 Are Essential for Tumor Angiogenesis [PDF]

Cancer Research Communications, 2022
Neuropilin (NRP) expression is highly correlated with poor outcome in multiple cancer subtypes. As known coreceptors for VEGFRs, core drivers of angiogenesis, past investigations have alluded to their functional roles in facilitating tumorigenesis by promoting invasive vessel growth. Despite this, it remains unclear as to whether NRP1 and NRP2 act in a
Christopher J. Benwell, Robert T. Johnson, James A.G.E. Taylor, Christopher A. Price, Stephen D. Robinson   +4 more
openaire   +3 more sources

Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea. [PDF]

PLoS Genetics, 2017
Neuropilin-1 (Nrp1) encodes the transmembrane cellular receptor neuropilin-1, which is associated with cardiovascular and neuronal development and was within the peak SNP interval on chromosome 8 in our prior GWAS study on age-related hearing loss (ARHL)
Pezhman Salehi, Marshall X Ge, Usha Gundimeda, Leah Michelle Baum, Homero Lael Cantu, Joel Lavinsky, Litao Tao, Anthony Myint, Charlene Cruz, Juemei Wang, Angeliki Maria Nikolakopoulou, Carolina Abdala, Matthew William Kelley, Takahiro Ohyama, Thomas Matthew Coate, Rick A Friedman   +15 more
doaj   +1 more source

Neuropilin-1-VEGFR-2 Complexing Requires the PDZ-binding Domain of Neuropilin-1 [PDF]

Journal of Biological Chemistry, 2008
Vascular endothelial growth factor (VEGF) acts as a hierarchically high switch of the angiogenic cascade by interacting with its high affinity VEGF receptors and with neuropilin co-receptors. VEGF(165) binds to both Neuropilin-1 (NP-1) and VEGFR-2, and it is believed that ligand binding forms an extracellular bridge between both molecules.
Claudia, Prahst, Mélanie, Héroult, Anthony A, Lanahan, Noa, Uziel, Ofra, Kessler, Niva, Shraga-Heled, Michael, Simons, Gera, Neufeld, Hellmut G, Augustin   +8 more
openaire   +2 more sources

Neuropilin 1 regulates bone marrow vascular regeneration and hematopoietic reconstitution

Nature Communications, 2021
Ionizing radiation and chemotherapy deplete haematopoietic stem cells and damage the vascular niche. Here the authors show that irradiation induces SEMA3A secretion from bone marrow endothelial cells (ECs), inducing EC apoptosis via NRP1 and that NRP1 ...
Christina M. Termini, Amara Pang, Tiancheng Fang, Martina Roos, Vivian Y. Chang, Yurun Zhang, Nicollette J. Setiawan, Lia Signaevskaia, Michelle Li, Mindy M. Kim, Orel Tabibi, Paulina K. Lin, Joshua P. Sasine, Avradip Chatterjee, Ramachandran Murali, Heather A. Himburg, John P. Chute   +16 more
doaj   +1 more source

Novel Small-Molecule Inhibitors of the SARS-CoV-2 Spike Protein Binding to Neuropilin 1

Pharmaceuticals, 2022
Furin cleavage of the SARS-CoV-2 spike protein results in a polybasic terminal sequence termed the C-end rule (CendR), which is responsible for the binding to neuropilin 1 (NRP1), enhancing viral infectivity and entry into the cell.
Anja Kolarič, Marko Jukič, Urban Bren
doaj   +1 more source

Myeloid‐resident neuropilin‐1 promotes choroidal neovascularization while mitigating inflammation

EMBO Molecular Medicine, 2021
Age‐related macular degeneration (AMD) in its various forms is a leading cause of blindness in industrialized countries. Here, we provide evidence that ligands for neuropilin‐1 (NRP1), such as Semaphorin 3A and VEGF‐A, are elevated in the vitreous of ...
Elisabeth M M A Andriessen, François Binet, Frédérik Fournier, Masayuki Hata, Agnieszka Dejda, Gaëlle Mawambo, Sergio Crespo‐Garcia, Frédérique Pilon, Manuel Buscarlet, Karine Beauchemin, Véronique Bougie, Garth Cumberlidge, Ariel M Wilson, Steve Bourgault, Flavio A Rezende, Normand Beaulieu, Jean‐Sébastien Delisle, Przemyslaw Sapieha   +17 more
doaj   +1 more source

Metabolic Stress Induces the Lysosomal Degradation of Neuropilin-1 but Not Neuropilin-2 [PDF]

Journal of Biological Chemistry, 2008
The neuropilins-1 and -2 (NRP1 and NRP2) function as receptors for both the semaphorins and vascular endothelial growth factor. In addition to their contribution to the development of the nervous system, NRP1 and NRP2 have been implicated in angiogenesis and tumor progression. Given their importance to cancer and endothelial biology and their potential
Bae, Donggoo, Lu, Shaolei, Taglienti, Cherie A., Mercurio, Arthur M.   +3 more
openaire   +3 more sources