Results 11 to 20 of about 15,068 (213)
Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesis [PDF]
Development, 2014 Neuropilin 1 (NRP1) is a receptor for class 3 semaphorins and vascular endothelial growth factor (VEGF) A and is essential for cardiovascular development. Biochemical evidence supports a model for NRP1 function in which VEGF binding induces complex formation between NRP1 and VEGFR2 to enhance endothelial VEGF signalling.
Fantin, A +7 more
core +7 more sources
VEGF189 binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain [PDF]
Development, 2015 The vascular endothelial growth factor (VEGFA, VEGF) regulates neurovascular patterning. Alternative splicing of the Vegfa gene gives rise to three major isoforms termed VEGF121, VEGF165 and VEGF189. VEGF165 binds the transmembrane protein neuropilin 1 (NRP1) and promotes the migration, survival and axon guidance of subsets of neurons, whereas VEGF121 ...
Tillo, Miguel +6 more
openaire +6 more sources
Pseudokinase NRP1 facilitates endocytosis of transferrin in the African trypanosome
Scientific Reports, 2022 Trypanosoma brucei causes human African trypanosomiasis (HAT) and nagana in cattle. During infection of a vertebrate, endocytosis of host transferrin (Tf) is important for viability of the parasite.
Gaurav Kumar +2 more
doaj +3 more sources
NRP1 function and targeting in neurovascular development and eye disease [PDF]
Progress in Retinal and Eye Research, 2016 Neuropilin 1 (NRP1) is expressed by neurons, blood vessels, immune cells and many other cell types in the mammalian body and binds a range of structurally and functionally diverse extracellular ligands to modulate organ development and function. In recent years, several types of mouse knockout models have been developed that have provided useful tools ...
Raimondi, Claudio +3 more
core +7 more sources
Selective requirements for NRP1 ligands during neurovascular patterning [PDF]
Development, 2007 Blood vessels and neurons share several types of guidance cues and cell surface receptors to control their behaviour during embryogenesis. The transmembrane protein NRP1 is present on blood vessels and nerves. NRP1 binds two structurally diverse ligands, the semaphorin SEMA3A and the VEGF164 isoform of vascular endothelial growth factor.
Vieira, J, Schwarz, Q, Ruhrberg, C
openaire +4 more sources
NRP1 regulation of endothelial cell signalling [PDF]
, 2017 Neuropilin 1 (NRP1) is a transmembrane protein that is essential for blood vessel growth and the regulation of vascular barrier properties. Yet, at the time of starting my PhD research, it was poorly understood how NRP1 affects endothelial cell behaviour
Lampropoulou, Anastasia Syrmalenia
openaire +2 more sources
Targeting NRP1 with EG00229 induces neurovascular permeability [PDF]
, 2023 Abstract NRP1 is a therapeutic target for inhibiting vascular endothelial growth factor (VEGF)-induced blood vessel dysfunction. The small molecule EG00229 was designed to inhibit VEGF binding to NRP1 and reduce pathological blood vessel growth. However, it is unknown whether EG00229 could also be used to reduce VEGF164-induced vascular
Silvia Dragoni +6 more
openaire +2 more sources
Neuropilin-1/GIPC1 signaling regulates alpha5beta1 integrin traffic and function in endothelial cells. [PDF]
PLoS Biology, 2009 Neuropilin 1 (Nrp1) is a coreceptor for vascular endothelial growth factor A165 (VEGF-A165, VEGF-A164 in mice) and semaphorin 3A (SEMA3A). Nevertheless, Nrp1 null embryos display vascular defects that differ from those of mice lacking either VEGF-A164 or
Donatella Valdembri +10 more
doaj +2 more sources
Investigating the role of NRP1 in vascular patterning
, 2023 Defective cardiovascular development can cause congenital heart defects. The transmembrane protein NRP1 promotes the remodelling of the foetal cardiac outflow tract into the base of the pulmonary artery and aorta and the remodelling of the primitive ...
Ioannou, Elena
openaire +2 more sources
Dynamics of VEGF-A binding at VEGFR2 and NRP1 [PDF]
, 2020 Vascular Endothelial Growth Factor A (VEGF-A) is a key mediator of angiogenesis, a process dysregulated in tumour development. Alternative splicing of the Vegfa gene leads to distinct endogenous VEGF-A isoforms with differential signalling and expression.
Peach, Chloe J
openaire +2 more sources