Results 71 to 80 of about 14,577 (178)

In‐Vitro Evaluation of HIV/SARS‐CoV‐2 Co‐Infection Mediated Proteomic Changes in Astrocytes and Pericytes Reveals Altered Signaling Pathways Associated With Neurodegenerative Disorders

Journal of Medical Virology, Volume 98, Issue 8, August 2026.
ABSTRACT Coronavirus disease 2019 (COVID‐19) survivors frequently experience a wide range of symptoms known as post‐acute sequelae of SARS‐CoV‐2 (PASC) or long COVID. Importantly, complications arising from microvascular dysfunction, blood‐brain barrier (BBB) disruption, and chronic neuroinflammation have been implicated in driving PASC within the ...
Arpan Acharya, Michellie Thurman, Debapriya Sutar, Oluwatayo Israel Olasunkanmi, Johid R. Malik, Shetty Ravi Dyavar, Ákos Végvári, Siddappa N. Byrareddy   +7 more
wiley   +1 more source

Neuropilin-1 expression is associated with lymph node metastasis in breast cancer tissues

Cancer Management and Research, 2018
Mahnaz Seifi-Alan,1 Roshanak Shams,1 Mojgan Bandehpour,2 Reza Mirfakhraie,1 Soudeh Ghafouri-Fard1 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Biotechnology, School of Advanced Technologies
Seifi-Alan M, Shams R, Bandehpour M, Mirfakhraie R, Ghafouri-Fard S   +4 more
doaj  

Human neuropilin-1 biomarker as predictor of subclinical cardiovascular affection in systemic lupus erythematosus patients

Egyptian Rheumatology and Rehabilitation
Background Cardiovascular disease (CVD) is recognized as the leading cause of death in patients with systemic lupus erythematosus (SLE). Although the pathways involved in accelerated cardiovascular disease are not yet fully understood, atherogenesis may ...
Samar Gaber Soliman, Samah Samy Yossef, Shaimaa R. Shahin, Dina Mamdoh Serag, Dalia S. Saif   +4 more
doaj   +1 more source

Lentiviral Mediated Expression of Soluble Neuropilin 1 Inhibits Semaphorin 3A-mediated Collapse Activity in Vitro

Basic and Clinical Neuroscience, 2021
Introduction: Semaphorin 3A (Sema 3A) is a secreted protein, which plays an integral part in developing the nervous system. It has collapse activity on the growth cone of dorsal root ganglia.
Keivan Nedaei, Mahdi Hesaraki, Saeideh Mazloomzadeh, Mehdi Totonchi, Ali Reza Biglari   +4 more
doaj  

Lymphatic Endothelial Cells in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang, Wang Lin, Hengyang Liu, Jixin Zhong, Shiliang Li, Xiaoquan Rao   +5 more
wiley   +1 more source

Neuropilin-1 Acts as a Receptor for Complement Split Products

Frontiers in Immunology, 2019
Complement split products (CSPs), such as the fragments C4d and C3d, which are generated as a consequence of complement regulatory processes, are established markers for disease activity in autoimmunity or antibody-mediated graft rejection.
Claire Battin, Annika De Sousa Linhares, Wolfgang Paster, Wolfgang Paster, David E. Isenman, Markus Wahrmann, Judith Leitner, Gerhard J. Zlabinger, Peter Steinberger, Johannes Hofer   +9 more
doaj   +1 more source

Proteomic and Phosphoproteomic Characteristics of Multiple Brain Regions in Rhesus Macaques After SARS‐CoV‐2 Infection

MedComm, Volume 7, Issue 8, August 2026.
The study found that SARS‐CoV‐2 Omicron infection causes region‐specific inflammatory, immune, synaptic, and signaling disorders in the brain, and the predicted kinases and differentially expressed proteins may serve as potential targets for COVID‐19‐related drug discovery.
Qiaochu Wang, Yanan Zhou, Tao Ding, Yan Sun, Yehong Yang, Yue Wu, Jiangfeng Liu, Shuaiyao Lu, Juntao Yang   +8 more
wiley   +1 more source

Triazolopeptides Inhibiting the Interaction between Neuropilin-1 and Vascular Endothelial Growth Factor-165

Molecules, 2019
Inhibiting the interaction of neuropilin-1 (NRP-1) with vascular endothelial growth factor (VEGF) has become an interesting mechanism for potential anticancer therapies.
Bartlomiej Fedorczyk, Piotr F. J. Lipiński, Anna K. Puszko, Dagmara Tymecka, Beata Wilenska, Wioleta Dudka, Gerard Y. Perret, Rafal Wieczorek, Aleksandra Misicka   +8 more
doaj   +1 more source

A noncanonical role for Jagged1 in endothelial mechanotransduction

The FEBS Journal, Volume 293, Issue 15, Page 4604-4623, August 2026.
The Notch signaling pathway plays a crucial role in regulating endothelial biology. Notch signaling is sensitive to hemodynamic forces and governs mechanically driven cardiovascular development, physiology, and remodeling. This study reveals a non‐canonical role for the Notch ligand Jagged1 in endothelial mechanotransduction.
Freddy Suarez Rodriguez, Noora Virtanen, Elmeri Kiviluoto, Rob C. H. Driessen, Feihu Zhao, Carlijn V. C. Bouten, Oscar M. J. A. Stassen, Cecilia M. Sahlgren   +7 more
wiley   +1 more source

Identification of an osteopontin-derived peptide that binds neuropilin-1 and activates vascular repair responses and angiogenesis

Pharmacological Research
The osteopontin-derived peptide FOL-005 stimulates hair growth. Using ligand-receptor glyco-capture technology we identified neuropilin-1 (NRP-1), a known co-receptor for vascular endothelial growth factor (VEGF) receptors, as the most probable receptor ...
Yihong Chen, Chrysostomi Gialeli, Junyan Shen, Pontus Dunér, Björn Walse, Annette Duelli, Rhawnie Caing-Carlsson, Anna M. Blom, John R. Zibert, Anna Hultgårdh Nilsson, Jan Alenfall, Chun Liang, Jan Nilsson   +12 more
doaj   +1 more source