Results 81 to 90 of about 21,250,288 (213)

Pubertal development and hypothalamic–pituitary–gonadal axis are altered in male mice lacking Mecp2

Journal of Neuroendocrinology, Volume 38, Issue 7, July 2026.
Abstract Mutations in the MECP2 gene, encoding the epigenetic reader Methyl‐CpG binding protein 2, are the main cause of Rett syndrome, a rare neurodevelopmental disorder. Besides severe symptoms such as profound intellectual disability, loss of speech and motor skills, and epilepsy, loss of function of MECP2 has been associated with pubertal ...
Ana Martín‐Sánchez, Daniela Jiménez‐Díaz, Rafael Esteve‐Pérez, Alexandru Vasile‐Tudorache, Jordan E. Read, Sasha R. Howard, Carmen Agustín‐Pavón   +6 more
wiley   +1 more source

Neoadjuvant Chemotherapy Alters Neuropilin-1, PlGF, and SNAI1 Expression Levels and Predicts Breast Cancer Patients Response

Frontiers in Oncology, 2019
Circulating proteins hold a potential benefit as biomarkers for precision medicine. Previously, we showed that systemic levels of neuropilin-1 (NRP-1) and its associated molecules correlated with poor-prognosis breast cancer. To further identify the role
Noura Al-Zeheimi, Adviti Naik, Charles Saki Bakheit, Marwa Al Riyami, Adil Al Ajarrah, Suaad Al Badi, Khalid Al Baimani, Kamran Malik, Zamzam Al Habsi, Mansour S. Al Moundhri, Sirin A. Adham   +10 more
doaj   +1 more source

Aptamer‐Based Delivery Systems for VEGF and NGF Modulation in Ocular Therapies

Advanced Healthcare Materials, Volume 15, Issue 23, 19 June 2026.
Aptamer‐based delivery systems targeting NGF and VEGF hold significant potential for precise and sustained treatment of complex diseases affecting both the anterior and posterior segments of the eye. This review critically summarizes current strategies for NGF and VEGF delivery as well as VEGF sequestration, providing a clinical perspective on how ...
Nadine Best, Gizem Karabiyik, Gerd Geerling, Sarah Barbara Zwingelberg, Gregor Lang, Martin Humenik   +5 more
wiley   +1 more source

VSMC phenotypic switching in thoracic aortic aneurysm at single‐cell resolution: Trajectories, regulatory circuits, and spatial niches

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
•Single‐cell/spatial multi‐omics identify four VSMC phenotypic states in TAA progression. •KLF4 as master hub (TGF‐β/TNF‐α/mechanical stress) orchestrating chromatin remodelling. •Pseudotime trajectories mapping contractile phenotypes towards osteogenic (RUNX2/SOX9) and inflammatory (TNF‐α/IL‐6) fates within spatial medial niches. •cfDNA biomarkers and
Zehua Shao, Chunguang Guo, Zhongyuan Lu, Jianyang Liu, Hao Tang, Hongwei Guo, Zhidong Zhang   +6 more
wiley   +1 more source

Neuropilin‐1 regulates renin synthesis in juxtaglomerular cells

International audienceAbstract Renin is the key enzyme of the systemic renin–angiotensin–aldosterone system, which plays an essential role in regulating blood pressure and maintaining electrolyte and extracellular volume homeostasis.
Buob, David, Shen, Yunzhu, Chatziantoniou, Christos, Louedec, Liliane, Verpont, Marie‐christine, Hadchouel, Juliette, Broeker, Katharina A.‐e., Frère, Perrine, Placier, Sandrine, Terzi, Fabiola, Lotenberg, Kenza, Zaworski, Jeremy, Calmont, Amélie, Vasseur, Florence, Galichon, Pierre   +14 more
core   +1 more source

Design of a Cyclotide Antagonist of Neuropilin‑1 and -2 That Potently Inhibits Endothelial Cell Migration

, 2016
Neuropilin-1 and -2 are critical regulators of angiogenesis, lymphangiogenesis, and cell survival as receptors for multiple growth factors. Disulfide-rich peptides that antagonize the growth factor receptors neuropilin-1 and neuropilin-2 were developed ...
David J. Craik (13753), Olivier Cheneval (1430590), Patrick S. Daugherty (49807), Jennifer A. Getz (1944187)   +3 more
core   +1 more source

Enhancement of Circulating and Intestinal T Regulatory Cells and Their Expression of Helios and Neuropilin-1 in Children with Inflammatory Bowel Disease

Journal of Inflammation Research, 2020
Katarzyna Sznurkowska,1 Justyna Luty,2 Ewa Bryl,2 Jacek M Witkowski,3 Blanka Hermann-Okoniewska,4 Piotr Landowski,1 Marta Kosek,1 Agnieszka Szlagatys-Sidorkiewicz1 1Department of Pediatrics, Pediatric Gastroenterology, Allergology and Nutrition, Medical ...
Sznurkowska K, Luty J, Bryl E, Witkowski JM, Hermann-Okoniewska B, Landowski P, Kosek M, Szlagatys-Sidorkiewicz A   +7 more
doaj  

DAMP Laden Extracellular Vesicles From the Airways of Patients With Severe SARS‐CoV‐2 Respiratory Infection Compromise Inflammation and Cellular Metabolism

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Extracellular vesicles from severe COVID‐19 airways carry depleted miRNAs and elevated DAMPs, reprogramming monocytes toward senescence, impaired metabolism, and predominantly reduced cytokine responses. However, they drive excess IL‐8 production, amplifying neutrophil recruitment and dysfunctional inflammation across the respiratory tract.
April Rees, Oliver Richards, Molly E Raikes, Megan Chambers, Sophie G Reed, Ceri Battle, Hannah Toghill, Luke Newey, Tyler J Joseph, Haiyan An, Hui Zhang, Iain Perry, Jason Webber, Nicholas Jones, Catherine A Thornton   +14 more
wiley   +1 more source

Design of a cyclotide antagonist of neuropilin-1 and-2 that potently inhibits endothelial cell migration

, 2013
Neuropilin-1 and -2 are critical regulators of angiogenesis, lymphangiogenesis, and cell survival as receptors for multiple growth factors. Disulfide-rich peptides that antagonize the growth factor receptors neuropilin-1 and neuropilin-2 were developed ...
Cheneval, Olivier, Craik, David J., Daugherty, Patrick S., Getz, Jennifer A.   +3 more
core   +1 more source

Systemically Administered, Target-Specific, Multi-Functional Therapeutic Recombinant Proteins in Regenerative Medicine

Nanomaterials, 2020
Growth factors, chemokines and cytokines guide tissue regeneration after injuries. However, their applications as recombinant proteins are almost non-existent due to the difficulty of maintaining their bioactivity in the protease-rich milieu of injured ...
Tero A.H. Järvinen, Toini Pemmari
doaj   +1 more source