Results 21 to 30 of about 14,577 (178)

Perspectives and potential approaches for targeting neuropilin 1 in SARS-CoV-2 infection

Molecular Medicine, 2021
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a novel type b coronavirus responsible for the COVID-19 pandemic. With over 224 million confirmed infections with this virus and more than 4.6 million people dead because of it, it is ...
Svetlana P. Chapoval, Achsah D. Keegan
doaj   +1 more source

Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma

Journal of Experimental & Clinical Cancer Research, 2021
Background Despite the improvement of relapse-free survival mediated by anti-angiogenic drugs like sunitinib (Sutent®), or by combinations of anti-angiogenic drugs with immunotherapy, metastatic clear cell Renal Cell Carcinoma (mccRCC) remain incurable ...
Aurore Dumond, Etienne Brachet, Jérôme Durivault, Valérie Vial, Anna K. Puszko, Yves Lepelletier, Christopher Montemagno, Marina Pagnuzzi-Boncompagni, Olivier Hermine, Christiane Garbay, Nathalie Lagarde, Matthieu Montes, Luc Demange, Renaud Grépin, Gilles Pagès   +14 more
doaj   +1 more source

Identification of circulating neuropilin-1 and dose-dependent elevation following anti-neuropilin-1 antibody administration [PDF]

mAbs, 2009
Neuropilin-1 (NRP1) acts as a co-receptor for class 3 semaphorins and vascular endothelial growth factor and is an attractive angiogenesis target for cancer therapy. In addition to the transmembrane form, naturally occurring soluble NRP1 proteins containing part of the extracellular domain have been identified in tissues and a cell line.
Yanmei, Lu, Hong, Xiang, Peter, Liu, Raymond R, Tong, Ryan J, Watts, Alexander W, Koch, Wendy N, Sandoval, Lisa A, Damico, Wai Lee, Wong, Y Gloria, Meng   +9 more
openaire   +2 more sources

Significance of Neuropilin-1 Expression in Acute Myeloid Leukemia

Turkish Journal of Hematology, 2013
Objective: Neuropilin-1 is a vascular endothelial growth factor receptor that acts as a mediator of angiogenesis. Its importance in hematological malignancies such as acute myeloid leukemia (AML) remains to be elucidated.
Tarif H. Sallam, Manal A.shams Eldin El Telbany, Hanan M. Mahmoud, Mutea A. Iskander   +3 more
doaj   +1 more source

MiR-200c sensitizes Olaparib-resistant ovarian cancer cells by targeting Neuropilin 1

Journal of Experimental & Clinical Cancer Research, 2020
Background Ovarian cancer (OC) is the most lethal gynecological malignancy and the second leading cause of cancer-related death in women. Treatment with PARP inhibitors (PARPi), such as Olaparib, has been recently introduced for OC patients, but ...
Enrica Vescarelli, Giulia Gerini, Francesca Megiorni, Eleni Anastasiadou, Paola Pontecorvi, Luciana Solito, Claudia De Vitis, Simona Camero, Claudia Marchetti, Rita Mancini, Pierluigi Benedetti Panici, Carlo Dominici, Ferdinando Romano, Antonio Angeloni, Cinzia Marchese, Simona Ceccarelli   +15 more
doaj   +1 more source

Neuropilin-1 Regulates the Secondary CD8 T Cell Response to Virus Infection

mSphere, 2019
Neuropilin-1 (Nrp1) plays important roles in axonal guidance in neurons and in the growth of new blood vessels. There is also a growing appreciation for roles played by neuropilin-1 in the immune response.
Ji Young Hwang, Yanbo Sun, Christopher R. Carroll, Edward J. Usherwood   +3 more
doaj   +1 more source

Epidermal expression of neuropilin 1 protects murine keratinocytes from UVB-induced apoptosis. [PDF]

PLoS ONE, 2012
BACKGROUND: Neuropilin 1 (NRP1) is expressed on several cell types including neurons and endothelial cells, where it functions as an important regulator in development and during angiogenesis.
Anna Riese, Yvonne Eilert, Yvonne Meyer, Meral Arin, Jens M Baron, Sabine Eming, Thomas Krieg, Peter Kurschat   +7 more
doaj   +1 more source

Soluble Neuropilin-1 in gingival crevicular fluid from periodontitis patients: An exploratory cross-sectional study

Journal of Oral Biology and Craniofacial Research, 2021
Background: Soluble Neuropilin-1 (sNRP-1) is a glycoprotein with angiogenic and immune regulatory functions, which correspond to processes deeply involved with periodontal diseases.
Diego Prieto, Gloria Maurer, Maximiliano Sáez, Felipe Cáceres, Karina Pino-Lagos, Alejandra Chaparro   +5 more
doaj   +1 more source

Chemoenzymatic Synthesis of Well‐Defined α(2,8)‐ and α(2,9)‐Linked Oligosialosides

Angewandte Chemie, EarlyView.
Well‐defined α(2,8)‐ and α(2,9)‐linked oligosialic acids of different lengths can be prepared by employing recombinant bacterial polysialyltransferases in combination with chemically modified CMP‐Neu5Ac derivatives. After transfer, a sialoside is formed bearing an artificial entity, which blocks further glycosylation.
Jelle A. Fok, Keshav Kishor, Mehman I. Bunyatov, Gerlof P. Bosman, Geert‐Jan Boons   +4 more
wiley   +2 more sources

N-glycosylation-defective splice variants of neuropilin-1 promote metastasis by activating endosomal signals

Nature Communications, 2019
O-glycosylation of neuropilin-1 is involved in cancer migration and invasion. Here, the authors show that defects in N-glycosylation of two neuropilin-1 splice variants enhance the co-internalisation of Met, it’s interaction with β1-integrin, and ...
Xiuping Huang, Qing Ye, Min Chen, Aimin Li, Wenting Mi, Yuxin Fang, Yekaterina Y. Zaytseva, Kathleen L. O’Connor, Craig W. Vander Kooi, Side Liu, Qing-Bai She   +10 more
doaj   +1 more source