Results 11 to 20 of about 21,250,288 (213)
Significance of Neuropilin-1 Expression in Acute Myeloid Leukemia
Turkish Journal of Hematology, 2013 Objective: Neuropilin-1 is a vascular endothelial growth factor receptor that acts as a mediator of angiogenesis. Its importance in hematological malignancies such as acute myeloid leukemia (AML) remains to be elucidated.
Tarif H. Sallam +3 more
doaj +4 more sources
Neuropilin-1 and Integrins as Receptors for Chromogranin A-Derived Peptides [PDF]
Pharmaceutics, 2022 Human chromogranin A (CgA), a 439 residue-long member of the “granin” secretory protein family, is the precursor of several peptides and polypeptides involved in the regulation of the innate immunity, cardiovascular system, metabolism, angiogenesis ...
Angelo Corti +2 more
doaj +6 more sources
Neuropilin-1 in Transplantation Tolerance [PDF]
Frontiers in Immunology, 2013 In the immune system, Neuropilin-1 (Nrp1) is a molecule that plays an important role in establishing the immunological synapse between dendritic cells (DCs) and T cells.
Mauricio eCampos-Mora +4 more
doaj +4 more sources
The role of Neuropilin-1 in COVID-19.
PLoS Pathogens, 2021 Neuropilin-1 (NRP-1), a member of a family of signaling proteins, was shown to serve as an entry factor and potentiate SARS Coronavirus 2 (SARS-CoV-2) infectivity in vitro.
Bindu S Mayi +5 more
doaj +5 more sources
A peptide corresponding to the neuropilin-1-binding site on VEGF165 induces apoptosis of neuropilin-1-expressing breast tumour cells [PDF]
British Journal of Cancer, 2005 There is increasing evidence that vascular endothelial growth factor (VEGF) has autocrine as well as paracrine functions in tumour biology. Vascular endothelial growth factor-mediated cell survival signalling occurs via the classical tyrosine kinase ...
David J. Bouchier-Hayes (7958009) +15 more
core +4 more sources
Neuropilin-1 as therapeutic target for malignant melanoma [PDF]
Frontiers in Oncology, 2015 Neuropilin-1 (NRP-1) is a transmembrane glycoprotein that acts as a co-receptor for various members of the VEGF family. Its ability to bind or modulate the activity of a number of other extracellular ligands, such as class 3 semaphorins, TGF-β, HGF, FGF ...
Grazia eGraziani, Pedro M Lacal
doaj +4 more sources
Neuropilin-1 expression is associated with lymph node metastasis in breast cancer tissues
Cancer Management and Research, 2018 Mahnaz Seifi-Alan,1 Roshanak Shams,1 Mojgan Bandehpour,2 Reza Mirfakhraie,1 Soudeh Ghafouri-Fard1 1Department of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran; 2Department of Biotechnology, School of Advanced Technologies
Seifi-Alan M +4 more
doaj +1 more source
Structural studies of neuropilin-1
, 2015 Neuropilin-1 (Nrp1) is ~130kDa multidomain type I transmembrane protein with no intrinsic enzymatic activity. Instead, acting as co-receptor in conjunction with other membrane proteins such as vascular endothelial growth factor receptors VEGFRs and ...
Yelland, TS
core +2 more sources
Basic and Clinical Neuroscience, 2021 Introduction: Semaphorin 3A (Sema 3A) is a secreted protein, which plays an integral part in developing the nervous system. It has collapse activity on the growth cone of dorsal root ganglia.
Keivan Nedaei +4 more
doaj +1 more source
Neuropilin-1-VEGFR-2 Complexing Requires the PDZ-binding Domain of Neuropilin-1 [PDF]
Journal of Biological Chemistry, 2008 Vascular endothelial growth factor (VEGF) acts as a hierarchically high switch of the angiogenic cascade by interacting with its high affinity VEGF receptors and with neuropilin co-receptors. VEGF(165) binds to both Neuropilin-1 (NP-1) and VEGFR-2, and it is believed that ligand binding forms an extracellular bridge between both molecules.
Claudia, Prahst +8 more
openaire +2 more sources