Isoforms of Neuropilin-2 Denote Unique Tumor-Associated Macrophages in Breast Cancer [PDF]
Frontiers in Immunology, 2022 Tumor-associated macrophages (TAMs) exert profound influence over breast cancer progression, promoting immunosuppression, angiogenesis, and metastasis. Neuropilin-2 (NRP2), consisting of the NRP2a and NRP2b isoforms, is a co-receptor for heparin-binding ...
Rajeev Dhupar +35 more
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Neuropilin 2 in osteoblasts regulates trabecular bone mass in male mice [PDF]
Frontiers in Endocrinology, 2023 IntroductionNeuropilin 2 (NRP2) mediates the effects of class 3 semaphorins and vascular endothelial growth factor and is implicated in axonal guidance and angiogenesis.
Lieve Verlinden +6 more
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Palmitoylation regulates neuropilin-2 localization and function in cortical neurons and conveys specificity to semaphorin signaling via palmitoyl acyltransferases [PDF]
eLife, 2023 Secreted semaphorin 3F (Sema3F) and semaphorin 3A (Sema3A) exhibit remarkably distinct effects on deep layer excitatory cortical pyramidal neurons; Sema3F mediates dendritic spine pruning, whereas Sema3A promotes the elaboration of basal dendrites ...
Eleftheria Koropouli +6 more
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The Role of Neuropilin-2 in the Epithelial to Mesenchymal Transition of Colorectal Cancer: A Systematic Review [PDF]
Biomedicines, 2022 Neuropilin-2 (NRP-2) expression has been found in various investigations on the expression and function of NRP-2 in colorectal cancer. The link between NRP-2 and colorectal cancer, as well as the mechanism that regulates it, is still mostly unclear. This
Cristina Lungulescu +4 more
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Neuropilin‐2 regulates airway inflammation in a neutrophilic asthma model [PDF]
Immunity, Inflammation and Disease, 2022 Background Asthma is a heterogenous disease that can be classified into eosinophilic (type 2‐high) and noneosinophilic (type 2‐low) endotypes. The type 2‐low endotype of asthma can be characterized by the presence of neutrophilic airway inflammation that
Robert M. Immormino +3 more
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Differential expression of viral entry protein neuropilin 1 (NRP1) and neuropilin 2 (NRP2) in fatal COVID-19 [PDF]
Journal of VirologyCoronavirus disease 2019 (COVID-19) is associated with hyperinflammation, endothelialitis, hypoxemia, and hypercoagulation, contributing to thrombosis in acute severe and long COVID. While ACE2 is the primary severe acute respiratory syndrome coronavirus
A. Dette +11 more
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Reduced hippocampal inhibition and enhanced autism-epilepsy comorbidity in mice lacking neuropilin 2 [PDF]
Translational Psychiatry, 2021 The neuropilin receptors and their secreted semaphorin ligands play key roles in brain circuit development by regulating numerous crucial neuronal processes, including the maturation of synapses and migration of GABAergic interneurons.
Carol Eisenberg +8 more
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N2E4, a Monoclonal Antibody Targeting Neuropilin-2, Inhibits Tumor Growth and Metastasis in Pancreatic Ductal Adenocarcinoma via Suppressing FAK/Erk/HIF-1α Signaling [PDF]
Frontiers in Oncology, 2021 Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with extremely limited treatment; the effective targeting strategy stays an urgent unmet need. Neuropilin-2 (NRP2), a multifunctional transmembrane non-tyrosine-kinase glycoprotein,
Li Wang +9 more
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Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma [PDF]
Journal of Experimental & Clinical Cancer Research, 2021 Background Despite the improvement of relapse-free survival mediated by anti-angiogenic drugs like sunitinib (Sutent®), or by combinations of anti-angiogenic drugs with immunotherapy, metastatic clear cell Renal Cell Carcinoma (mccRCC) remain incurable ...
Aurore Dumond +14 more
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Neuropilin-2 Is Associated With Increased Hepatoblastoma Cell Viability and Motility [PDF]
Frontiers in Pediatrics, 2021 The neuropilins NRP1 and NRP2 are multifunctional glycoproteins that have been implicated in several cancer-related processes including cell survival, migration, and invasion in various tumor types.
Katja Eloranta +9 more
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