Results 41 to 50 of about 14,350 (168)
The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems
Asian Journal of Pharmaceutical Sciences, 2019 Vascular endothelial growth factor receptor 2 (VEGFR-2) and neuropilin-1 (NRP-1) are two prominent antiangiogenic targets. They are highly expressed on vascular endothelial cells and some tumor cells.
Lu Lu +4 more
doaj +1 more source
Sonoselective Transfection of Glioma Endothelium
Advanced Science, EarlyView.Delivering non‐viral, gene‐bearing nanoparticles with thiol‐decorated surfaces to gliomas with focused ultrasound yields transfection tropism for endothelial cells. From this platform, “sonoselective” transfection of glioma endothelium is achieved via incorporation of an endothelial cell‐specific promoter.
Anna C. Debski +8 more
wiley +1 more source
Neuropilin-2–Mediated Tumor Growth and Angiogenesis in Pancreatic Adenocarcinoma [PDF]
Clinical Cancer Research, 2008 Abstract Purpose. Neuropilin-2 (NRP-2) is a coreceptor for vascular endothelial growth factor (VEGF) on endothelial cells. NRP-2 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) cells relative to nonmalignant ductal epithelium. This study determined the role of NRP-2 in PDAC cells. Experimental Design.
Nikolaos A, Dallas +11 more
openaire +2 more sources
Obstetrics and Gynecology International, 2009 While semaphorins and their receptors appear to play a role in tumor carcinogenesis, little is known about the role of semaphorin 3F (S3F) in epithelial ovarian cancer (EOC) development. Therefore, we sought to determine the clinical relationship between
Christina D. Drenberg +4 more
doaj +1 more source
Neoplasia: An International Journal for Oncology Research, 2005 Previously, we demonstrated that loss of SEMA3F, a secreted semaphorin encoded in 3p21.3, is associated with higher stages in lung cancer and primary tumor cells studied with anti-vascular endothelial growth factor (VEGF) and SEMA3F antibodies. In vitro,
Patrick Nasarre +6 more
doaj +1 more source
Physiological Reports, 2021 The coronavirus disease 2019 (COVID‐19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is threatening people's lives and impacting their health.
Yuki Tamura +4 more
doaj +1 more source
Neovascularization in Pancreatic Cancer is Dependent on Neuropilin 2
The FASEB Journal, 2019 Pancreatic ductal adenocarcinoma (PDAC) has a high mortality rate due to lack of detection, tendency to metastasize to the liver, and the absence of effective treatments. Consequently, there is an urgent need to understand the biology of this devastating disease in order to develop drugs to inhibit PDAC progression.
Orlane Destin +7 more
openaire +1 more source
Peripheral nerve regeneration is delayed in neuropilin 2–deficient mice [PDF]
Journal of Neuroscience Research, 2008 AbstractPeripheral nerve transection or crush induces expression of class 3 semaphorins by epineurial and perineurial cells at the injury site and of the neuropilins neuropilin‐1 and neuropilin‐2 by Schwann and perineurial cells in the nerve segment distal to the injury.
Peter, Bannerman +6 more
openaire +2 more sources
Semaphorins and Their Receptors in Hematological Malignancies
Frontiers in Oncology, 2019 While semaphorins were initially identified as axonal guidance cues for wiring the neural network, it was then recognized their wide relevance in tissue development and homeostasis.
Li Wei +6 more
doaj +1 more source
Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges
BMEMat, EarlyView.This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma +8 more
wiley +1 more source