Results 41 to 50 of about 17,667,571 (207)

Neuropilin-mediated neural crest cell guidance is essential to organise sensory neurons into segmented dorsal root ganglia

, 2009
The peripheral nervous system (PNS) of higher vertebrates is segmented to align the spinal nerve roots with the vertebrae. This co-patterning is set up during embryogenesis, when vertebrae develop from the sclerotome layer of the metameric somites, and ...
Maden, CH, Christiana Ruhrberg, Quenten Schwarz, Davidson, K., Schwarz, Q, Ruhrberg, C., Kathryn Davidson, Maden, C., Davidson, K, Ruhrberg, C, Schwarz, Q., Charlotte H. Maden   +11 more
core   +1 more source

Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland [PDF]

Development, 2011
Although the neuropilins were characterized as semaphorin receptors that regulate axon guidance, they also function as vascular endothelial growth factor (VEGF) receptors and contribute to the development of other tissues. Here, we assessed the role of NRP2 in mouse mammary gland development based on our observation that NRP2 is expressed ...
Goel, Hira Lal, Bae, Donggoo, Pursell, Bryan M., Gouvin, Lindsey M., Lu, Shaolei, Mercurio, Arthur M.   +5 more
openaire   +3 more sources

Peripheral nerve regeneration is delayed in neuropilin 2–deficient mice [PDF]

Journal of Neuroscience Research, 2008
AbstractPeripheral nerve transection or crush induces expression of class 3 semaphorins by epineurial and perineurial cells at the injury site and of the neuropilins neuropilin‐1 and neuropilin‐2 by Schwann and perineurial cells in the nerve segment distal to the injury.
Peter, Bannerman, Jahan, Ara, Ashleigh, Hahn, Lindy, Hong, Erica, McCauley, Katie, Friesen, David, Pleasure   +6 more
openaire   +2 more sources

Deletion of neuropilin 2 enhances detrusor contractility following bladder outlet obstruction.

, 2017
Chronic urethral obstruction and the ensuing bladder wall remodeling can lead to diminished bladder smooth muscle (BSM) contractility and debilitating lower urinary tract symptoms.
Ali Hashemi Gheinani, Cristofaro, Vivian, Hashemi Gheinani, Ali, Fiona C. Burkhard, Sullivan, Maryrose P, Adam, Rosalyn M, Vasquez, Evalynn, Evalynn Vasquez, Vivian Cristofaro, Stefan Lukianov, Katia Monastyrskaya, Diane R. Bielenberg, Lukianov, Stefan, Maryrose P. Sullivan, Monastyrskaya-Stäuber, Katia, Rosalyn M. Adam, Burkhard, Fiona C., Bielenberg, Diane R   +17 more
core   +1 more source

Neuropilin-1 facilitates SARS-CoV-2 cell entry and infectivity [PDF]

, 2020
The causative agent of coronavirus induced disease 2019 (COVID-19) is the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). For many viruses, tissue tropism is determined by the availability of virus receptors and entry cofactors on the ...
Vapalahti, Olli, Cantuti-Castelvetri, Ludovico, Stadelmann, Christine, Balistreri, Giuseppe, Gokce, Ozgun, Simons, Mikael, Kuivanen, Suvi, Teesalu, Tambet, Joensuu, Merja, Mollenhauer, Brit, Kaya, Tuğberk, Meunier, Frédéric A., Ojha, Ravi, Djannatian, Minou, Anastasina, Maria, Österlund, Pamela, van der Meer, Franziska, Kallio-Kokko, Hannimari, Pedro, Liliana D., Butcher, Sarah J., Hepojoki, Jussi, Franz, Jonas, Smura, Teemu, Helenius, Ari, Levanov, Lev, Meer, Franziska van der, Szirovicza, Leonora, Kallio, Katri, Tobi, Allan, Winkler, Martin Sebastian   +29 more
core   +3 more sources

Dorsal turning of motor corticospinal axons at the pyramidal decussation requires plexin signaling

Neural Development, 2008
Background The development of the corticospinal tract (CST) in higher vertebrates relies on a series of axon guidance decisions along its long projection pathway.
Coble Jeffrey, Liu Xiao-Bo, Low Lawrence K, Faulkner Regina L, Jones Edward G, Cheng Hwai-Jong   +5 more
doaj   +1 more source

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

Neovascularization in Pancreatic Cancer is Dependent on Neuropilin 2

The FASEB Journal, 2019
Pancreatic ductal adenocarcinoma (PDAC) has a high mortality rate due to lack of detection, tendency to metastasize to the liver, and the absence of effective treatments. Consequently, there is an urgent need to understand the biology of this devastating disease in order to develop drugs to inhibit PDAC progression.
Orlane Destin, Benoit Niclou, Xiaoran Li, Nicholas Levonyak, Amy Jia, Randy S. Watnick, Rosalyn M. Adam, Diane R. Bielenberg   +7 more
openaire   +1 more source

ACE-2, TMPRSS2, and Neuropilin-1 Receptor Expression on Human Brain Astrocytes and Pericytes and SARS-CoV-2 Infection Kinetics

, 2023
Angiotensin Converting Enzyme 2 (ACE-2), Transmembrane Serine Protease 2 (TMPRSS-2) and Neuropilin-1 cellular receptors support the entry of SARS-CoV-2 into susceptible human target cells and are characterized at the molecular level. Some evidence on the
Arpan Acharya, Johid Reza Malik, Sean N. Avedissian, Courtney V. Fletcher, Anthony T. Podany, Shetty Ravi Dyavar, Siddappa N. Byrareddy   +6 more
core   +1 more source

The functions and applications of A7R in anti-angiogenic therapy, imaging and drug delivery systems

Asian Journal of Pharmaceutical Sciences, 2019
Vascular endothelial growth factor receptor 2 (VEGFR-2) and neuropilin-1 (NRP-1) are two prominent antiangiogenic targets. They are highly expressed on vascular endothelial cells and some tumor cells.
Lu Lu, Hongyuan Chen, Dake Hao, Xinke Zhang, Fengshan Wang   +4 more
doaj   +1 more source