Results 31 to 40 of about 14,350 (168)

Multifaceted Role of Neuropilins in the Immune System: Potential Targets for Immunotherapy

Frontiers in Immunology, 2017
Neuropilins (NRPs) are non-tyrosine kinase cell surface glycoproteins expressed in all vertebrates and widely conserved across species. The two isoforms, such as neuropilin-1 (NRP1) and neuropilin-2 (NRP2), mainly act as coreceptors for class III ...
Sohini Roy, Arup K. Bag, Rakesh K. Singh, James E. Talmadge, Surinder K. Batra, Kaustubh Datta   +5 more
doaj   +1 more source

miR-331-3p Suppresses Cell Proliferation in TNBC Cells by Downregulating NRP2

Technology in Cancer Research & Treatment, 2020
Purpose: Triple-negative breast cancer is characterized by fast progression with high possible for metastasis and poor survival. Dysfunction of microRNAs plays an important role in the initiation and progression of cancer.
Mingchuan Zhao PhD, Mengmeng Zhang PhD, Zhonghua Tao PhD, Jun Cao PhD, Leiping Wang PhD, Xichun Hu PhD, MD   +5 more
doaj   +1 more source

Host Cell and SARS-CoV-2-Associated Molecular Structures and Factors as Potential Therapeutic Targets

Cells, 2021
Coronavirus disease 19 (COVID-19) is caused by an enveloped, positive-sense, single-stranded RNA virus, referred to as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which belongs to the realm Riboviria, order Nidovirales, family ...
Jitendra Kumar Chaudhary, Rohitash Yadav, Pankaj Kumar Chaudhary, Anurag Maurya, Rakesh Roshan, Faizul Azam, Jyoti Mehta, Shailendra Handu, Ramasare Prasad, Neeraj Jain, Avaneesh Kumar Pandey, Puneet Dhamija   +11 more
doaj   +1 more source

Semaphorin 3G exacerbates joint inflammation through the accumulation and proliferation of macrophages in the synovium

Arthritis Research & Therapy, 2022
Objectives Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA). However, the precise mechanisms by which MTX stalls RA progression and alleviates the ensuing disease effects remain unknown. The aim of the present study was
Jumpei Shoda, Shigeru Tanaka, Keishi Etori, Koto Hattori, Tadamichi Kasuya, Kei Ikeda, Yuko Maezawa, Akira Suto, Kotaro Suzuki, Junichi Nakamura, Yoshiro Maezawa, Minoru Takemoto, Christer Betsholtz, Koutaro Yokote, Seiji Ohtori, Hiroshi Nakajima   +15 more
doaj   +1 more source

Conservation and Enhanced Binding of SARS-CoV-2 Omicron Spike Protein to Coreceptor Neuropilin-1 Predicted by Docking Analysis

Infectious Disease Reports, 2022
The Omicron variant of SARS-CoV-2 bears peptide sequence alterations that correlate with a higher infectivity than was observed in the original SARS-CoV-2 isolated from Wuhan, China.
Piyush Baindara, Dinata Roy, Santi M. Mandal, Adam G. Schrum   +3 more
doaj   +1 more source

Epidermal expression of neuropilin 1 protects murine keratinocytes from UVB-induced apoptosis. [PDF]

PLoS ONE, 2012
BACKGROUND: Neuropilin 1 (NRP1) is expressed on several cell types including neurons and endothelial cells, where it functions as an important regulator in development and during angiogenesis.
Anna Riese, Yvonne Eilert, Yvonne Meyer, Meral Arin, Jens M Baron, Sabine Eming, Thomas Krieg, Peter Kurschat   +7 more
doaj   +1 more source

Tumor Necrosis Factor and Interleukin-1β Upregulate NRP2 Expression and Promote SARS-CoV-2 Proliferation

Viruses, 2023
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), utilizes the host receptor angiotensin-converting enzyme 2 (ACE2) and the auxiliary receptor Neuropilin-1 (NRP1) to enter host cells. NRP1 has
Michinori Ishitoku, Sho Mokuda, Kei Araki, Hirofumi Watanabe, Hiroki Kohno, Tomohiro Sugimoto, Yusuke Yoshida, Takemasa Sakaguchi, Junya Masumoto, Shintaro Hirata, Eiji Sugiyama   +10 more
doaj   +1 more source

Neuropilin-2 promotes branching morphogenesis in the mouse mammary gland [PDF]

Development, 2011
Although the neuropilins were characterized as semaphorin receptors that regulate axon guidance, they also function as vascular endothelial growth factor (VEGF) receptors and contribute to the development of other tissues. Here, we assessed the role of NRP2 in mouse mammary gland development based on our observation that NRP2 is expressed ...
Goel, Hira Lal, Bae, Donggoo, Pursell, Bryan M., Gouvin, Lindsey M., Lu, Shaolei, Mercurio, Arthur M.   +5 more
openaire   +3 more sources

Dorsal turning of motor corticospinal axons at the pyramidal decussation requires plexin signaling

Neural Development, 2008
Background The development of the corticospinal tract (CST) in higher vertebrates relies on a series of axon guidance decisions along its long projection pathway.
Coble Jeffrey, Liu Xiao-Bo, Low Lawrence K, Faulkner Regina L, Jones Edward G, Cheng Hwai-Jong   +5 more
doaj   +1 more source

Deconstruction of Human Age‐Related Cataract Capsules Defines Aging

Advanced Science, EarlyView.
We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang, Ziyang Tong, Chunmei Fan, Silong Chen, Jiarui Guo, Jianghua Hu, Ke Yao, Zi Yin, Xiao Chen, Yibo Yu   +9 more
wiley   +1 more source