Results 31 to 40 of about 17,667,571 (207)
Structural studies of neuropilin-2 reveal a zinc ion binding site away from the vascular endothelial growth factor binding pocket [PDF]
, 2016 Neuropilin-2 is a transmembrane receptor involved in lymphangiogenesis and neuronal development. In adults, neuropilin-2 and its homologous protein neuropilin-1 have been implicated in cancers and infection.
Ian Zachary +13 more
core +1 more source
Lymphatic and angiogenic candidate genes predict the development of secondary lymphedema following breast cancer surgery. [PDF]
PLoS ONE, 2013 The purposes of this study were to evaluate for differences in phenotypic and genotypic characteristics in women who did and did not develop lymphedema (LE) following breast cancer treatment.
Christine Miaskowski +11 more
doaj +1 more source
Implication of neuropilin 2/semaphorin 3F in retinocollicular map formation [PDF]
Developmental Dynamics, 2008 AbstractNeural representations of the environment within the brain take the form of topographic maps whose formation relies on graded expression of axon guidance molecules. Retinocollicular map formation, from retinal ganglion cells (RGCs) to the superior colliculus (SC) in the midbrain, is mainly driven by Eph receptors and their ligands ephrins ...
Claudepierre, Thomas +5 more
openaire +2 more sources
Multifaceted Role of Neuropilins in the Immune System: Potential Targets for Immunotherapy
Frontiers in Immunology, 2017 Neuropilins (NRPs) are non-tyrosine kinase cell surface glycoproteins expressed in all vertebrates and widely conserved across species. The two isoforms, such as neuropilin-1 (NRP1) and neuropilin-2 (NRP2), mainly act as coreceptors for class III ...
Sohini Roy +5 more
doaj +1 more source
Cells, 2021 Coronavirus disease 19 (COVID-19) is caused by an enveloped, positive-sense, single-stranded RNA virus, referred to as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which belongs to the realm Riboviria, order Nidovirales, family ...
Jitendra Kumar Chaudhary +11 more
doaj +1 more source
Neuropilin-2–Mediated Tumor Growth and Angiogenesis in Pancreatic Adenocarcinoma [PDF]
Clinical Cancer Research, 2008 Abstract Purpose. Neuropilin-2 (NRP-2) is a coreceptor for vascular endothelial growth factor (VEGF) on endothelial cells. NRP-2 is overexpressed in pancreatic ductal adenocarcinoma (PDAC) cells relative to nonmalignant ductal epithelium. This study determined the role of NRP-2 in PDAC cells. Experimental Design.
Nikolaos A, Dallas +11 more
openaire +2 more sources
miR-331-3p Suppresses Cell Proliferation in TNBC Cells by Downregulating NRP2
Technology in Cancer Research & Treatment, 2020 Purpose: Triple-negative breast cancer is characterized by fast progression with high possible for metastasis and poor survival. Dysfunction of microRNAs plays an important role in the initiation and progression of cancer.
Mingchuan Zhao PhD +5 more
doaj +1 more source
Arthritis Research & Therapy, 2022 Objectives Methotrexate (MTX) is an anchor drug for the treatment of rheumatoid arthritis (RA). However, the precise mechanisms by which MTX stalls RA progression and alleviates the ensuing disease effects remain unknown. The aim of the present study was
Jumpei Shoda +15 more
doaj +1 more source
Epidermal expression of neuropilin 1 protects murine keratinocytes from UVB-induced apoptosis. [PDF]
PLoS ONE, 2012 BACKGROUND: Neuropilin 1 (NRP1) is expressed on several cell types including neurons and endothelial cells, where it functions as an important regulator in development and during angiogenesis.
Anna Riese +7 more
doaj +1 more source
Viruses, 2023 Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which causes coronavirus disease 2019 (COVID-19), utilizes the host receptor angiotensin-converting enzyme 2 (ACE2) and the auxiliary receptor Neuropilin-1 (NRP1) to enter host cells. NRP1 has
Michinori Ishitoku +10 more
doaj +1 more source