Neuropilin-2 Is a Newly Identified Target of PAX8 in Thyroid Cells. [PDF]
PLoS ONE, 2015 PAX8 is a transcription factor essential for thyroid gland development, as well as for the maintenance of the thyroid differentiated state in the adult.
Valeria Lucci +2 more
doaj +7 more sources
Neuropilin-2 expression promotes TGF-β1-mediated epithelial to mesenchymal transition in colorectal cancer cells. [PDF]
PLoS ONE, 2011 Neuropilins, initially characterized as neuronal receptors, act as co-receptors for cancer related growth factors and were recently involved in several signaling pathways leading to cytoskeletal organization, angiogenesis and cancer progression. Then, we
Camille Grandclement +12 more
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Non-Coding RNA, 2021 Neuropilin-1 is a transmembrane glycoprotein that has been implicated in several processes including angiogenesis and immunity. Recent evidence has also shown that it is implied in the cellular internalization of the severe acute respiratory syndrome ...
Pasquale Mone +5 more
doaj +3 more sources
Smad3 Regulates Neuropilin 2 Transcription by Binding to its 5′ Untranslated Region [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Vascular smooth muscle cell phenotypic change and consequential intimal hyperplasia (IH) cause arterial stenosis and posttreatment restenosis.
Xiujie Xie +5 more
doaj +2 more sources
Rabies virus utilizes neuropilin 2 as an endocytic receptor to trigger TGFBR1-mediated actin polymerization [PDF]
Journal of VirologyRabies virus (RABV), belonging to the rhabdovirus, is a typical large virus that enters cells via clathrin-mediated endocytosis (CME). RABV-containing pits are only partially clathrin-coated and require local actin polymerization for efficient ...
Ziruo Sun +12 more
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Semaphorin 3F inhibits breast cancer metastasis by regulating the Akt-mTOR and TGFβ signaling pathways via neuropilin-2 [PDF]
Scientific ReportsClass 3 semaphorins are axon guidance factors implicated in tumor and vascular biology, including invasive activity. Recent studies indicate that semaphorin 3F (SEMA3F) is a potent inhibitor of metastasis; however, its functional role in breast cancer is
Hironao Nakayama +8 more
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Infectious Disease Reports, 2022 The Omicron variant of SARS-CoV-2 bears peptide sequence alterations that correlate with a higher infectivity than was observed in the original SARS-CoV-2 isolated from Wuhan, China.
Piyush Baindara +3 more
doaj +2 more sources
Neuropilin 2 Is a Novel Regulator of Distal Colon Contractility. [PDF]
Am J Pathol, 2022 Appropriate coordination of smooth muscle contraction and relaxation is essential for normal colonic motility. The impact of perturbed motility ranges from moderate, in conditions such as colitis, to potentially fatal in the case of pseudo-obstruction.
Lambrinos G +8 more
europepmc +3 more sources
Emerging Roles for Neuropilin-2 in Cardiovascular Disease. [PDF]
Int J Mol Sci, 2020 Cardiovascular disease, the leading cause of death worldwide, is predominantly associated with atherosclerosis. Atherosclerosis is a chronic inflammatory disease characterised by the narrowing of large to medium-sized arteries due to a build-up of plaque.
Harman JL +3 more
europepmc +3 more sources
Expression and clinical significance of neuropilin-2 in colorectal cancer: correlation with lymphangiogenic factors [PDF]
Korean Journal of Clinical Oncology, 2013 Purpose: Neuropilin-2 is expressed by venous and lymphatic endothelial cells and can bind the lymphangiogenesis-associated ligand vascular endothelial growth factor (VEGF)-C and D.
Hyunyong Lee +5 more
doaj +1 more source