N2E4, a Monoclonal Antibody Targeting Neuropilin-2, Inhibits Tumor Growth and Metastasis in Pancreatic Ductal Adenocarcinoma via Suppressing FAK/Erk/HIF-1α Signaling [PDF]
Frontiers in Oncology, 2021 Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with extremely limited treatment; the effective targeting strategy stays an urgent unmet need. Neuropilin-2 (NRP2), a multifunctional transmembrane non-tyrosine-kinase glycoprotein,
Li Wang +9 more
doaj +2 more sources
Neuropilin-2 Is a Newly Identified Target of PAX8 in Thyroid Cells. [PDF]
PLoS ONE, 2015 PAX8 is a transcription factor essential for thyroid gland development, as well as for the maintenance of the thyroid differentiated state in the adult.
Valeria Lucci +2 more
doaj +6 more sources
Neuropilin 1 and Neuropilin 2 gene invalidation or pharmacological inhibition reveals their relevance for the treatment of metastatic renal cell carcinoma [PDF]
Journal of Experimental & Clinical Cancer Research, 2021 Background Despite the improvement of relapse-free survival mediated by anti-angiogenic drugs like sunitinib (Sutent®), or by combinations of anti-angiogenic drugs with immunotherapy, metastatic clear cell Renal Cell Carcinoma (mccRCC) remain incurable ...
Aurore Dumond +14 more
doaj +2 more sources
Smad3 Regulates Neuropilin 2 Transcription by Binding to its 5′ Untranslated Region [PDF]
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2020 Background Vascular smooth muscle cell phenotypic change and consequential intimal hyperplasia (IH) cause arterial stenosis and posttreatment restenosis.
Xiujie Xie +5 more
doaj +2 more sources
Neuropilin-2: a novel biomarker for malignant melanoma? [PDF]
Human Pathology, 2012 Neuropilin-2, a cell surface receptor involved in angiogenesis and axonal guidance, has recently been shown to be a critical mediator of tumor-associated lymphangiogenesis. Given that lymphangiogenesis is a major conduit of metastasis in melanomas and that blocking neuropilin-2 function in vivo is effective in inhibiting tumor cell metastasis, we ...
Alaa Naif +2 more
exaly +3 more sources
Rabies virus utilizes neuropilin 2 as an endocytic receptor to trigger TGFBR1-mediated actin polymerization [PDF]
Journal of VirologyRabies virus (RABV), belonging to the rhabdovirus, is a typical large virus that enters cells via clathrin-mediated endocytosis (CME). RABV-containing pits are only partially clathrin-coated and require local actin polymerization for efficient ...
Ziruo Sun +12 more
doaj +2 more sources
Semaphorin 3F inhibits breast cancer metastasis by regulating the Akt-mTOR and TGFβ signaling pathways via neuropilin-2 [PDF]
Scientific ReportsClass 3 semaphorins are axon guidance factors implicated in tumor and vascular biology, including invasive activity. Recent studies indicate that semaphorin 3F (SEMA3F) is a potent inhibitor of metastasis; however, its functional role in breast cancer is
Hironao Nakayama +8 more
doaj +2 more sources
Neuropilin-2 regulates airway inflammatory responses to inhaled lipopolysaccharide. [PDF]
Am J Physiol Lung Cell Mol Physiol, 2018 Neuropilins are multifunctional receptors that play important roles in immune regulation. Neuropilin-2 (NRP2) is expressed in the lungs, but whether it regulates airway immune responses is unknown. Here, we report that Nrp2 is weakly expressed by alveolar macrophages (AMs) in the steady state but is dramatically upregulated following in vivo ...
Immormino RM +10 more
europepmc +3 more sources
EMBO Molecular Medicine, 2013 The characterization of cells with tumour initiating potential is significant for advancing our understanding of cancer and improving therapy. Aggressive, triple‐negative breast cancers (TNBCs) are enriched for tumour‐initiating cells (TICs).
Charlotte Kuperwasser +2 more
exaly +2 more sources
Non-Coding RNA, 2021 Neuropilin-1 is a transmembrane glycoprotein that has been implicated in several processes including angiogenesis and immunity. Recent evidence has also shown that it is implied in the cellular internalization of the severe acute respiratory syndrome ...
Pasquale Mone +5 more
doaj +1 more source