Results 21 to 30 of about 14,350 (168)

Expression and clinical significance of neuropilin-2 in colorectal cancer: correlation with lymphangiogenic factors [PDF]

Korean Journal of Clinical Oncology, 2013
Purpose: Neuropilin-2 is expressed by venous and lymphatic endothelial cells and can bind the lymphangiogenesis-associated ligand vascular endothelial growth factor (VEGF)-C and D.
Hyunyong Lee, Taesung Ahn, Dongjun Jung, Haeil Jung, Moonsoo Lee, Moo-jun Baek   +5 more
doaj   +1 more source

Neuropilin-2 expression promotes TGF-β1-mediated epithelial to mesenchymal transition in colorectal cancer cells. [PDF]

PLoS ONE, 2011
Neuropilins, initially characterized as neuronal receptors, act as co-receptors for cancer related growth factors and were recently involved in several signaling pathways leading to cytoskeletal organization, angiogenesis and cancer progression. Then, we
Camille Grandclement, Jean René Pallandre, Séverine Valmary Degano, Erika Viel, Adeline Bouard, Jérémy Balland, Jean-Paul Rémy-Martin, Benoit Simon, Alain Rouleau, Wilfrid Boireau, Michael Klagsbrun, Christophe Ferrand, Christophe Borg   +12 more
doaj   +1 more source

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea. [PDF]

PLoS Genetics, 2017
Neuropilin-1 (Nrp1) encodes the transmembrane cellular receptor neuropilin-1, which is associated with cardiovascular and neuronal development and was within the peak SNP interval on chromosome 8 in our prior GWAS study on age-related hearing loss (ARHL)
Pezhman Salehi, Marshall X Ge, Usha Gundimeda, Leah Michelle Baum, Homero Lael Cantu, Joel Lavinsky, Litao Tao, Anthony Myint, Charlene Cruz, Juemei Wang, Angeliki Maria Nikolakopoulou, Carolina Abdala, Matthew William Kelley, Takahiro Ohyama, Thomas Matthew Coate, Rick A Friedman   +15 more
doaj   +1 more source

Semaphorin 3F Serves as a Tumor Suppressor in Esophageal Squamous Cell Carcinoma and is Associated With Lymph Node Metastasis in Disease Progression

Technology in Cancer Research & Treatment, 2020
Background: Esophageal squamous cell carcinoma is one of the leading aggressive malignancies with high mortality. Semaphorin 3F has been reported to be involved in lymphangiogenesis by interacting the vascular endothelial growth factor C/neuropilin 2 ...
Zhen Xie MD, Tianyue Li MD, Bingtao Huang MM, Shuai Liu MM, Lianguo Zhang MM, Qingguang Zhang MD   +5 more
doaj   +1 more source

Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency [PDF]

The American Journal of Pathology, 2016
The vasculature influences the progression and resolution of tissue inflammation. Capillaries express vascular endothelial growth factor (VEGF) receptors, including neuropilins (NRPs), which regulate interstitial fluid flow. NRP2, a receptor of VEGFA and semaphorin (SEMA) 3F ligands, is expressed in the vascular and lymphatic endothelia.
Patrick, Mucka, Nicholas, Levonyak, Elena, Geretti, Bernadette M M, Zwaans, Xiaoran, Li, Irit, Adini, Michael, Klagsbrun, Rosalyn M, Adam, Diane R, Bielenberg   +8 more
openaire   +2 more sources

Lymphatic and angiogenic candidate genes predict the development of secondary lymphedema following breast cancer surgery. [PDF]

PLoS ONE, 2013
The purposes of this study were to evaluate for differences in phenotypic and genotypic characteristics in women who did and did not develop lymphedema (LE) following breast cancer treatment.
Christine Miaskowski, Marylin Dodd, Steven M Paul, Claudia West, Deborah Hamolsky, Gary Abrams, Bruce A Cooper, Charles Elboim, John Neuhaus, Brian L Schmidt, Betty Smoot, Bradley E Aouizerat   +11 more
doaj   +1 more source

miR-331-3p regulates expression of neuropilin-2 in glioblastoma [PDF]

Journal of Neuro-Oncology, 2013
Aberrant expression of microRNAs (miRNAs), a class of small non-coding regulatory RNAs, has been implicated in the development and progression of high-grade gliomas. However, the precise mechanistic role of many miRNAs in this disease remains unclear. Here, we investigate the functional role of miR-331-3p in glioblastoma multiforme (GBM). We found that
Epis, Michael R., Giles, Keith M., Candy, Patrick A., Webster, Rebecca J., Leedman, Peter J.   +4 more
openaire   +2 more sources

Chemoenzymatic Synthesis of Well‐Defined α(2,8)‐ and α(2,9)‐Linked Oligosialosides

Angewandte Chemie, EarlyView.
Well‐defined α(2,8)‐ and α(2,9)‐linked oligosialic acids of different lengths can be prepared by employing recombinant bacterial polysialyltransferases in combination with chemically modified CMP‐Neu5Ac derivatives. After transfer, a sialoside is formed bearing an artificial entity, which blocks further glycosylation.
Jelle A. Fok, Keshav Kishor, Mehman I. Bunyatov, Gerlof P. Bosman, Geert‐Jan Boons   +4 more
wiley   +2 more sources

Implication of neuropilin 2/semaphorin 3F in retinocollicular map formation [PDF]

Developmental Dynamics, 2008
AbstractNeural representations of the environment within the brain take the form of topographic maps whose formation relies on graded expression of axon guidance molecules. Retinocollicular map formation, from retinal ganglion cells (RGCs) to the superior colliculus (SC) in the midbrain, is mainly driven by Eph receptors and their ligands ephrins ...
Claudepierre, Thomas, Koncina, E, Pfrieger, Frank, Bagnard, Dominique, Aunis, D, Reber, Michael   +5 more
openaire   +2 more sources