Results 21 to 30 of about 17,667,571 (207)

Endothelial VEGFR Coreceptors Neuropilin-1 and Neuropilin-2 Are Essential for Tumor Angiogenesis. [PDF]

Cancer Res Commun, 2022
Neuropilin (NRP) expression is highly correlated with poor outcome in multiple cancer subtypes. As known coreceptors for VEGFRs, core drivers of angiogenesis, past investigations have alluded to their functional roles in facilitating tumorigenesis by ...
Benwell CJ, Johnson RT, Taylor JAGE, Price CA, Robinson SD.   +4 more
europepmc   +2 more sources

ALK1 controls hepatic vessel formation, angiodiversity, and angiocrine functions in hereditary hemorrhagic telangiectasia of the liver

Hepatology, EarlyView., 2022
Hepatic endothelial Alk1 signaling protects from development of vascular malformations while maintaining organ‐specific endothelial differentiation and angiocrine portmanteau of the names Wingless and Int‐1 signaling. Abstract Background and Aims In hereditary hemorrhagic telangiectasia (HHT), severe liver vascular malformations are associated with ...
Christian David Schmid, Victor Olsavszky, Manuel Reinhart, Vanessa Weyer, Felix A. Trogisch, Carsten Sticht, Manuel Winkler, Sina W. Kürschner, Johannes Hoffmann, Roxana Ola, Theresa Staniczek, Joerg Heineke, Beate K. Straub, Jens Mittler, Kai Schledzewski, Peter ten Dijke, Karsten Richter, Steven Dooley, Cyrill Géraud, Sergij Goerdt, Philipp‐Sebastian Koch   +20 more
wiley   +1 more source

Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea. [PDF]

PLoS Genetics, 2017
Neuropilin-1 (Nrp1) encodes the transmembrane cellular receptor neuropilin-1, which is associated with cardiovascular and neuronal development and was within the peak SNP interval on chromosome 8 in our prior GWAS study on age-related hearing loss (ARHL)
Pezhman Salehi, Marshall X Ge, Usha Gundimeda, Leah Michelle Baum, Homero Lael Cantu, Joel Lavinsky, Litao Tao, Anthony Myint, Charlene Cruz, Juemei Wang, Angeliki Maria Nikolakopoulou, Carolina Abdala, Matthew William Kelley, Takahiro Ohyama, Thomas Matthew Coate, Rick A Friedman   +15 more
doaj   +1 more source

Neuropilin 1 and 2 control cranial gangliogenesis and axon guidance through neural crest cells [PDF]

, 2008
Neuropilin (NRP) receptors and their class 3 semaphorin (SEMA3) ligands play well-established roles in axon guidance, with loss of NRP1, NRP2, SEMA3A or SEMA3F causing defasciculation and errors in growth cone guidance of peripherally projecting nerves ...
Howard, Beatrice, Christiana Ruhrberg, Quenten Schwarz, Britta J. Eickholt, Beatrice Howard, Vieira, J., Vieira, Joaquim M.; id_orcid, Ruhrberg, C., Howard, B, Ruhrberg, Christiana, Vieira, JM, Schwarz, Quenten, Joaquim M. Vieira, Eickholt, BJ, Schwarz, Q, Eickholt, Britta J., Howard, B., Eickholt, B., Ruhrberg, C, Schwarz, Q.P.   +19 more
core   +1 more source

Semaphorin 3F Serves as a Tumor Suppressor in Esophageal Squamous Cell Carcinoma and is Associated With Lymph Node Metastasis in Disease Progression

Technology in Cancer Research & Treatment, 2020
Background: Esophageal squamous cell carcinoma is one of the leading aggressive malignancies with high mortality. Semaphorin 3F has been reported to be involved in lymphangiogenesis by interacting the vascular endothelial growth factor C/neuropilin 2 ...
Zhen Xie MD, Tianyue Li MD, Bingtao Huang MM, Shuai Liu MM, Lianguo Zhang MM, Qingguang Zhang MD   +5 more
doaj   +1 more source

Inflammation and Lymphedema Are Exacerbated and Prolonged by Neuropilin 2 Deficiency [PDF]

The American Journal of Pathology, 2016
The vasculature influences the progression and resolution of tissue inflammation. Capillaries express vascular endothelial growth factor (VEGF) receptors, including neuropilins (NRPs), which regulate interstitial fluid flow. NRP2, a receptor of VEGFA and semaphorin (SEMA) 3F ligands, is expressed in the vascular and lymphatic endothelia.
Patrick, Mucka, Nicholas, Levonyak, Elena, Geretti, Bernadette M M, Zwaans, Xiaoran, Li, Irit, Adini, Michael, Klagsbrun, Rosalyn M, Adam, Diane R, Bielenberg   +8 more
openaire   +2 more sources

Neuropilin-1/GIPC1 signaling regulates α5β1 integrin traffic and function in endothelial cells [PDF]

, 2009
Neuropilin 1 (Nrp1) is a coreceptor for vascular endothelial growth factor A165 (VEGF-A165, VEGF-A164 in mice) and semaphorin 3A (SEMA3A). Nevertheless, <i>Nrp1</i> null embryos display vascular defects that differ from those of mice lacking ...
Caccavari, Francesca, Valdembri, D., Serini, G., Valdembri, Donatella, Caccavari, F., Caswell Patrick T, Anderson, K.I., Humphries, M.J., Patrick T Caswell, Anderson Kurt I, Anderson, Kurt I., Serini, Guido, Caccavari Francesca, Federico Bussolino, Elena Astanina, Valdembri Donatella, König, I., König, Ireen, Astanina, Elena, Schwarz, J.P., Francesca Caccavari, Jim C Norman, Humphries Martin J, Bussolino, F., Schwarz Juliane P, Guido Serini, Serini Guido, König Ireen, Schwarz, Juliane P., Bussolino, Federico, Kurt I Anderson, Humphries, Martin J., Caswell, Patrick T.; id_orcid, Norman, Jim C., Juliane P Schwarz, Astanina Elena, Astanina, E., Bussolino Federico, Norman, J.C., Donatella Valdembri, Caswell, P.T., Ireen König, Norman Jim C, Martin J Humphries   +43 more
core   +1 more source

Neuropilin-1 is a host factor for SARS-CoV-2 infection [PDF]

, 2020
SARS-CoV-2, the causative agent of COVID-19, uses the viral Spike (S) protein for host cell attachment and entry. The host protease furin cleaves the full-length precursor S glycoprotein into two associated polypeptides: S1 and S2.
Kavanagh Williamson, Maia, Chen, Kai-En, Horvath, P, Simón-Gracia, Lorena, Hiscox, JA, Greber, Urs F., Hollandi, Reka, Chen, KE, Hollandi, R, Williamson, MK, Teesalu, Tambet, Shoemark, Deborah K., Matthews, DA, Antón-Plágaro, Carlos, Williamson, Maia K., Greber, UF, Simonetti, Boris, Hiscox, Julian A., Daly, James L., Klein, K, Bauer, M, Yamauchi, Y, Horvath, Peter, Shoemark, DK, Simonetti, B, Davidson, AD, Williamson, Maia Kavanagh, Antón-Plágaro, C, Davidson, Andrew D., Simón-Gracia, L, Helenius, Ari, Yamauchi, Yohei, Cullen, PJ, Sessions, Richard B., Matthews, David A., Collins, Brett M., Daly, JL, Klein, Katja, Cullen, Peter J., Yamauchi, Yohei; id_orcid, Bauer, Michael, Collins, BM, Sessions, RB, Helenius, A, Teesalu, T   +44 more
core   +3 more sources

miR-331-3p regulates expression of neuropilin-2 in glioblastoma [PDF]

Journal of Neuro-Oncology, 2013
Aberrant expression of microRNAs (miRNAs), a class of small non-coding regulatory RNAs, has been implicated in the development and progression of high-grade gliomas. However, the precise mechanistic role of many miRNAs in this disease remains unclear. Here, we investigate the functional role of miR-331-3p in glioblastoma multiforme (GBM). We found that
Epis, Michael R., Giles, Keith M., Candy, Patrick A., Webster, Rebecca J., Leedman, Peter J.   +4 more
openaire   +2 more sources

Neuropilin-2 regulates the development of selective cranial and sensory nerves and hippocampal mossy fiber projections [PDF]

, 2000
Neuropilin-1 and neuropilin-2 bind differentially to different class 3 semaphorins and are thought to provide the ligand-binding moieties in receptor complexes mediating repulsive responses to these semaphorins.
Chédotal, A, Zou, Yimin, Zou, Y, Zupicich, J A, Tessier-Lavigne, Marc, Pleasure, S J, Bagri, A, Lowenstein, D H, Chédotal, Alain, Tessier-Lavigne, M, Chen, Hang, Lowenstein, Daniel H, Stoeckli, Esther, Skarnes, William C, Stoeckli, E T; https://orcid.org/, Zupicich, Joel A, Chen, H, Bagri, Anil, Pleasure, Samuel J, Skarnes, W C   +19 more
core   +1 more source