Results 51 to 60 of about 17,667,571 (207)

Effects of endurance training on the expression of host proteins involved in SARS‐CoV‐2 cell entry in C57BL/6J mouse

Physiological Reports, 2021
The coronavirus disease 2019 (COVID‐19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), is threatening people's lives and impacting their health.
Yuki Tamura, Eunbin Jee, Karina Kouzaki, Takaya Kotani, Koichi Nakazato   +4 more
doaj   +1 more source

Dual Physiological Barriers Bypassed by a Silk‐Based Supramolecular Protein Delivery Platform for Neuroinflammation Mitigation in Alzheimer's Disease

Advanced Science, EarlyView.
A supramolecular nanocomplex based on phenolic‐modified silk sericin is developed to deliver antioxidant enzymes across the blood–brain barrier and escape lysosomal degradation. This dual‐barrier‐crossing system reduces neuroinflammation and improves cognitive performance in Alzheimer's disease mouse model, offering a promising strategy for protein ...
Doudou Hu, Tiandong Li, Jian He, Yujian Jiang, Yeyuan Wang, Jingchen Sun   +5 more
wiley   +1 more source

Semaphorin SEMA3F Has a Repulsing Activity on Breast Cancer Cells and Inhibits E-Cadherin-Mediated Cell Adhesion

Neoplasia: An International Journal for Oncology Research, 2005
Previously, we demonstrated that loss of SEMA3F, a secreted semaphorin encoded in 3p21.3, is associated with higher stages in lung cancer and primary tumor cells studied with anti-vascular endothelial growth factor (VEGF) and SEMA3F antibodies. In vitro,
Patrick Nasarre, Sophie Kusy, Bruno Constantin, Valérie Castellani, Harry A. Drabkin, Dominique Bagnard, Joëlle Roche   +6 more
doaj   +1 more source

Beyond Potency: Emerging Determinants and Optimization Strategies Enhancing Therapeutic Efficacy of Adult Stem Cells

Advanced Science, EarlyView.
Adult stem cell therapy requires more than high in vitro potency. This review proposes a systems framework in which cell‐intrinsic programs, instructive microenvironmental cues, and pre‐/post‐delivery engineering are co‐designed under standardized translational rules.
Soo‐Rim Kim, Yun Jae Jung, Hwa‐Yong Lee   +2 more
wiley   +1 more source

Increased Smooth Muscle Contractility in Mice Deficient for Neuropilin 2

The American Journal of Pathology, 2012
Neuropilins (NRPs) are transmembrane receptors that bind class 3 semaphorins and VEGF family members to regulate axon guidance and angiogenesis. Although expression of NRP1 by vascular smooth muscle cells (SMCs) has been reported, NRP function in smooth muscle (SM) in vivo is unexplored.
Bielenberg, Diane R., Seth, Abhishek, Shimizu, Akio, Pelton, Kristine, Cristofaro, Vivian, Ramachandran, Aruna, Zwaans, Bernadette M.M., Chen, Cheng, Krishnan, Ramaswamy, Seth, Meetu, Huang, Lin, Takashima, Seiji, Klagsbrun, Michael, Sullivan, Maryrose P., Adam, Rosalyn M.   +14 more
openaire   +2 more sources

Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis [PDF]

Cancer Cell, 2008
Metastasis, which commonly uses lymphatics, accounts for much of the mortality associated with cancer. The vascular endothelial growth factor (VEGF)-C coreceptor, neuropilin-2 (Nrp2), modulates but is not necessary for developmental lymphangiogenesis, and its significance for metastasis is unknown. An antibody to Nrp2 that blocks VEGFC binding disrupts
Caunt, Maresa, Mak, Judy, Liang, Wei-Ching, Stawicki, Scott, Pan, Qi, Tong, Raymond K., Kowalski, Joe, Ho, Calvin, Reslan, Hani Bou, Ross, Jed, Berry, Leanne, Kasman, Ian, Zlot, Constance, Cheng, Zhiyong, Le Couter, Jennifer, Filvaroff, Ellen H., Plowman, Greg, Peale, Franklin, French, Dorothy, Carano, Richard, Koch, Alexander W., Wu, Yan, Watts, Ryan J., Tessier-Lavigne, Marc, Bagri, Anil   +24 more
openaire   +2 more sources

Expression of Semaphorin 3F and Its Receptors in Epithelial Ovarian Cancer, Fallopian Tubes, and Secondary Müllerian Tissues

Obstetrics and Gynecology International, 2009
While semaphorins and their receptors appear to play a role in tumor carcinogenesis, little is known about the role of semaphorin 3F (S3F) in epithelial ovarian cancer (EOC) development. Therefore, we sought to determine the clinical relationship between
Christina D. Drenberg, Sandra Livingston, Ren Chen, Patricia A. Kruk, Santo V. Nicosia   +4 more
doaj   +1 more source

Characterization of peptide binding to the SARS-CoV-2 host factor neuropilin

Heliyon, 2021
The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health concern.
Amie Jobe, Ranjit Vijayan
doaj   +1 more source

Anifrolumab Treatment Leads to Rapid Reduction in Urinary Biomarkers of Intrarenal Inflammation in Lupus Nephritis: Results From the Phase 2 Randomized Trial

Arthritis &Rheumatology, EarlyView.
Objective Lupus nephritis (LN) is one of the most severe manifestations of systemic lupus erythematosus (SLE) and is partially driven by type I interferon signaling. Anifrolumab, an approved treatment for patients with SLE, has been investigated in a phase 2 trial in patients with LN receiving standard therapy (TULIP‐LN, ClinicalTrials.gov identifier ...
Andrea Fava, Michelle Petri, Patrick G. Gavin, Eszter Csomor, Philip Z. Brohawn, Daniel Muthas, Adam Platt, Catharina Lindholm, Nicola Ferrari   +8 more
wiley   +1 more source

Neuropilin-2, a Novel Member of the Neuropilin Family, Is a High Affinity Receptor for the Semaphorins Sema E and Sema IV but Not Sema III

, 1997
Semaphorins are a large family of secreted and transmembrane proteins, several of which are implicated in repulsive axon guidance. Neuropilin (neuropilin-1) was recently identified as a receptor for Collapsin-1/Semaphorin III/D (Sema III).
Chen, Hang, Tessier-Lavigne, Marc, He, Zhigang, Goodman, Corey S, Chédotal, Alain   +4 more
core   +1 more source