Results 51 to 60 of about 14,350 (168)

Increased Smooth Muscle Contractility in Mice Deficient for Neuropilin 2

The American Journal of Pathology, 2012
Neuropilins (NRPs) are transmembrane receptors that bind class 3 semaphorins and VEGF family members to regulate axon guidance and angiogenesis. Although expression of NRP1 by vascular smooth muscle cells (SMCs) has been reported, NRP function in smooth muscle (SM) in vivo is unexplored.
Bielenberg, Diane R., Seth, Abhishek, Shimizu, Akio, Pelton, Kristine, Cristofaro, Vivian, Ramachandran, Aruna, Zwaans, Bernadette M.M., Chen, Cheng, Krishnan, Ramaswamy, Seth, Meetu, Huang, Lin, Takashima, Seiji, Klagsbrun, Michael, Sullivan, Maryrose P., Adam, Rosalyn M.   +14 more
openaire   +2 more sources

Characterization of peptide binding to the SARS-CoV-2 host factor neuropilin

Heliyon, 2021
The ongoing coronavirus disease 2019 (COVID-19) pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is a global health concern.
Amie Jobe, Ranjit Vijayan
doaj   +1 more source

Goofy/123Cre lineage tracing differentiates olfactory and vomeronasal neurons from GnRH‐1 and terminal nerve neurons during neuronal migration and reveals additional olfactory placode‐derived cells in the brain

Developmental Dynamics, EarlyView.
Abstract The olfactory placode (OP) generates a broad array of chemosensory neurons in the nasal region, including olfactory sensory neurons, vomeronasal sensory neurons, neurons of the septal organ, and Grueneberg ganglion. During invagination, the OP also generates migratory neuronal populations, including gonadotropin‐releasing hormone‐1 (GnRH‐1 ...
Enrico Amato Jr., Mia V. Call, Noah M. LeFever, Mya Aviles‐Carlos, Nikki M. Dolphin, Paolo E. Forni   +5 more
wiley   +1 more source

Blocking Neuropilin-2 Function Inhibits Tumor Cell Metastasis [PDF]

Cancer Cell, 2008
Metastasis, which commonly uses lymphatics, accounts for much of the mortality associated with cancer. The vascular endothelial growth factor (VEGF)-C coreceptor, neuropilin-2 (Nrp2), modulates but is not necessary for developmental lymphangiogenesis, and its significance for metastasis is unknown. An antibody to Nrp2 that blocks VEGFC binding disrupts
Caunt, Maresa, Mak, Judy, Liang, Wei-Ching, Stawicki, Scott, Pan, Qi, Tong, Raymond K., Kowalski, Joe, Ho, Calvin, Reslan, Hani Bou, Ross, Jed, Berry, Leanne, Kasman, Ian, Zlot, Constance, Cheng, Zhiyong, Le Couter, Jennifer, Filvaroff, Ellen H., Plowman, Greg, Peale, Franklin, French, Dorothy, Carano, Richard, Koch, Alexander W., Wu, Yan, Watts, Ryan J., Tessier-Lavigne, Marc, Bagri, Anil   +24 more
openaire   +2 more sources

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

Deficiency of Neuropilin 2 Suppresses VEGF-Induced Retinal Neovascularization

Molecular Medicine, 2004
Vascular endothelial growth factor (VEGF) plays a central role in the development of ocular neovascularization (NV) and is an excellent target for therapeutic intervention. VEGF acts through several receptors, including VEGF receptor 1, VEGF receptor 2, neuropilin-1 (Npn1), and Npn2, but the exact role of these receptors in the development of retinal ...
Jikui, Shen, Rebecca, Samul, Joelle, Zimmer, Hansheng, Liu, Xiaoling, Liang, Sean, Hackett, Peter A, Campochiaro   +6 more
openaire   +2 more sources

Plasma and Synovial Fluid VEGF‐A and Neuropilin‐1 in Knee Osteoarthritis: Associations With Radiographic Severity, Pain Sensitization‐Related Features, and Disease Burden

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to investigate associations of plasma and synovial fluid vascular endothelial growth factor A (VEGF‐A) and neuropilin‐1 (NRP1) levels with radiographic severity, pain sensitization‐related features, and disease burden in knee osteoarthritis (KOA). Plasma VEGF‐A and NRP1 were measured by sandwich ELISA in 120 patients with KOA (
Cheng‐Ju Tan
wiley   +1 more source

Structural Basis for Vascular Endothelial Growth Factor Receptor Activation and Implications for Disease Therapy

Biomolecules, 2020
Vascular endothelial growth factors (VEGFs) bind to membrane receptors on a wide variety of cells to regulate diverse biological responses. The VEGF-A family member promotes vasculogenesis and angiogenesis, processes which are essential for vascular ...
Faheem Shaik, Gary A. Cuthbert, Shervanthi Homer-Vanniasinkam, Stephen P. Muench, Sreenivasan Ponnambalam, Michael A. Harrison   +5 more
doaj   +1 more source

Advances and challenges in experimental models for Epstein–Barr virus research

mLife, EarlyView.
Abstract Epstein–Barr virus (EBV), the first identified human oncovirus, is a ubiquitous γ‐herpesvirus etiologically linked to diverse malignancies, lymphoproliferative disorders, and autoimmune diseases. Experimental models are pivotal for unraveling the infection and pathogenesis mechanisms, life cycle regulation, as well as development and ...
Gulimire Wufuer, Jiabao Tang, Tingdong Li, Shengxiang Ge, Jun Zhang, Ningshao Xia   +5 more
wiley   +1 more source

Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins

Mechanisms of Development, 2001
Neuropilin-1 (np1) and neuropilin-2 (np2) are receptors for class-3 semaphorins and for several isoforms of VEGF. We have cloned and characterized two chick isoforms of np2 cDNA. Expression patterns of np1, np2, and ephrin-B2 were compared in the developing vascular system of 24-72 h old chick embryos.
Herzog, Yael, Kalcheim, Chaya, Kahane, Nitza, Reshef, Ram, Neufeld, Gera   +4 more
openaire   +2 more sources