Results 31 to 40 of about 14,670 (186)
Sensors, 2017 In this paper we describe a two-component BRET (bioluminescence resonance energy transfer)-based method to detect vascular endothelial growth factor (VEGF) molecules in unknown samples as the basis for subsequent in vivo use.
Tobias Wimmer +3 more
doaj +1 more source
New Biosensor for Determination of Neuropilin-1 with Detection by Surface Plasmon Resonance Imaging
Sensors, 2023 Neuropilin-1 is transmembrane protein with soluble isoforms. It plays a pivotal role in both physiological and pathological processes. NRP-1 is involved in the immune response, formation of neuronal circuits, angiogenesis, survival and migration of cells.
Anna Sankiewicz +4 more
doaj +1 more source
Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins
Mechanisms of Development, 2001 Neuropilin-1 (np1) and neuropilin-2 (np2) are receptors for class-3 semaphorins and for several isoforms of VEGF. We have cloned and characterized two chick isoforms of np2 cDNA. Expression patterns of np1, np2, and ephrin-B2 were compared in the developing vascular system of 24-72 h old chick embryos.
Herzog, Yael +4 more
openaire +2 more sources
Metabolic Stress Induces the Lysosomal Degradation of Neuropilin-1 but Not Neuropilin-2 [PDF]
Journal of Biological Chemistry, 2008 The neuropilins-1 and -2 (NRP1 and NRP2) function as receptors for both the semaphorins and vascular endothelial growth factor. In addition to their contribution to the development of the nervous system, NRP1 and NRP2 have been implicated in angiogenesis and tumor progression. Given their importance to cancer and endothelial biology and their potential
Bae, Donggoo +3 more
openaire +3 more sources
Technology in Cancer Research & Treatment, 2020 Background: Esophageal squamous cell carcinoma is one of the leading aggressive malignancies with high mortality. Semaphorin 3F has been reported to be involved in lymphangiogenesis by interacting the vascular endothelial growth factor C/neuropilin 2 ...
Zhen Xie MD +5 more
doaj +1 more source
World Journal of Gastroenterology, 2015 Neuropilins (NRPs) are highly conserved transmembrane glycoproteins that possess pleiotropic functions. Neuropilin-1 (NRP1) and its homologue neuropilin-2 interact as coreceptors with both class 3 semaphorins and vascular endothelial growth factor and are involved in neuronal guidance and angiogenesis, respectively.
openaire +2 more sources
Control of cellular motility by neuropilin-mediated physical interactions
Biomolecular Concepts, 2014 The neuropilin (Nrp) family consists of multifunctional cell surface receptors with critical roles in a number of different cell and tissue types. A core aspect of Nrp function is in ligand-dependent cellular migration, where it controls the multistep ...
Li Xiaobo +2 more
doaj +1 more source
Significance of Neuropilin-1 Expression in Acute Myeloid Leukemia
Turkish Journal of Hematology, 2013 Objective: Neuropilin-1 is a vascular endothelial growth factor receptor that acts as a mediator of angiogenesis. Its importance in hematological malignancies such as acute myeloid leukemia (AML) remains to be elucidated.
Tarif H. Sallam +3 more
doaj +1 more source
Neuropilin-1 and Integrins as Receptors for Chromogranin A-Derived Peptides
Pharmaceutics, 2022 Human chromogranin A (CgA), a 439 residue-long member of the “granin” secretory protein family, is the precursor of several peptides and polypeptides involved in the regulation of the innate immunity, cardiovascular system, metabolism, angiogenesis ...
Angelo Corti +2 more
doaj +1 more source
Deconstruction of Human Age‐Related Cataract Capsules Defines Aging
Advanced Science, EarlyView.We generate a comprehensive atlas of age‐related cataracts (ARC) at a single‐cell resolution, encompassing three disease states—mild cataract group (Mild), severe cortical cataract group (Severe_C), and severe nuclear cataract group (Severe_N). We find that ARC involves seven distinct lens capsule cell types, with notable differences in cellular ...
Qiaomei Tang +9 more
wiley +1 more source