Results 31 to 40 of about 17,164 (224)

The Role of Neuropilin-2 in the Epithelial to Mesenchymal Transition of Colorectal Cancer: A Systematic Review

Biomedicines, 2022
Neuropilin-2 (NRP-2) expression has been found in various investigations on the expression and function of NRP-2 in colorectal cancer. The link between NRP-2 and colorectal cancer, as well as the mechanism that regulates it, is still mostly unclear. This
Cristina Lungulescu, Valentina Ghimpau, Dan Ionut Gheonea, Daniel Sur, Cristian Virgil Lungulescu   +4 more
doaj   +1 more source

Metabolic Stress Induces the Lysosomal Degradation of Neuropilin-1 but Not Neuropilin-2 [PDF]

Journal of Biological Chemistry, 2008
The neuropilins-1 and -2 (NRP1 and NRP2) function as receptors for both the semaphorins and vascular endothelial growth factor. In addition to their contribution to the development of the nervous system, NRP1 and NRP2 have been implicated in angiogenesis and tumor progression. Given their importance to cancer and endothelial biology and their potential
Bae, Donggoo, Lu, Shaolei, Taglienti, Cherie A., Mercurio, Arthur M.   +3 more
openaire   +3 more sources

Molecular Aspects of HTLV-1 Entry: Functional Domains of the HTLV-1 Surface Subunit (SU) and Their Relationships to the Entry Receptors

Viruses, 2011
The initial step in retroviral infection involves specific interactions between viral envelope proteins (Env) and specific receptors on the surface of target cells. For many years, little was known about the entry receptors for HTLV-1.
Sophie Lambert, Manuella Bouttier, Laurence Bénit, Frank W. Ruscetti, Olivier Hermine, Claudine Pique, Kathryn S. Jones   +6 more
doaj   +1 more source

Neuropilin 1 Regulation of Vascular Permeability Signaling

Biomolecules, 2021
The vascular endothelium acts as a selective barrier to regulate macromolecule exchange between the blood and tissues. However, the integrity of the endothelium barrier is compromised in an array of pathological settings, including ischemic disease and ...
Alison Domingues, Alessandro Fantin
doaj   +1 more source

Differential expression of neuropilin-1 and neuropilin-2 in arteries and veins

Mechanisms of Development, 2001
Neuropilin-1 (np1) and neuropilin-2 (np2) are receptors for class-3 semaphorins and for several isoforms of VEGF. We have cloned and characterized two chick isoforms of np2 cDNA. Expression patterns of np1, np2, and ephrin-B2 were compared in the developing vascular system of 24-72 h old chick embryos.
Herzog, Yael, Kalcheim, Chaya, Kahane, Nitza, Reshef, Ram, Neufeld, Gera   +4 more
openaire   +2 more sources

Detection of the Vascular Endothelial Growth Factor with a Novel Bioluminescence Resonance Energy Transfer Pair Using a Two-Component System

Sensors, 2017
In this paper we describe a two-component BRET (bioluminescence resonance energy transfer)-based method to detect vascular endothelial growth factor (VEGF) molecules in unknown samples as the basis for subsequent in vivo use.
Tobias Wimmer, Eva Schroeter, Birgit Lorenz, Knut Stieger   +3 more
doaj   +1 more source

New Biosensor for Determination of Neuropilin-1 with Detection by Surface Plasmon Resonance Imaging

Sensors, 2023
Neuropilin-1 is transmembrane protein with soluble isoforms. It plays a pivotal role in both physiological and pathological processes. NRP-1 is involved in the immune response, formation of neuronal circuits, angiogenesis, survival and migration of cells.
Anna Sankiewicz, Beata Zelazowska-Rutkowska, Ewelina Gorska, Adam Hermanowicz, Ewa Gorodkiewicz   +4 more
doaj   +1 more source

Neuropilin-2b facilitates resistance to tyrosine kinase inhibitors in non–small cell lung cancer

, 2020
OBJECTIVE: Innate and acquired resistance is the principle factor limiting the efficacy of tyrosine kinase inhibitors in lung cancer. We have observed a dramatic upregulation of the cell surface co-receptor neuropilin-2b in lung cancers clinically ...
Kent E. Armeson, Cecile Nasarre, Yuri K. Peterson, Nasarre, Patrick, Gooz, Monika, Monika Gooz, Drabkin, Harry A., Barry C. Gibney, Chadrick E. Denlinger, Peterson, Yuri K., Harry A. Drabkin, Robert M. Gemmill, Patrick Nasarre, Nasarre, Cecile, Armeson, Kent E., Anastasios Dimou, Gibney, Barry C., Gemmill, Robert M., Pagano, Rose, Denlinger, Chadrick E., Rose Pagano, Dimou, Anastasios   +21 more
core   +1 more source

Neuropilins and liver

World Journal of Gastroenterology, 2015
Neuropilins (NRPs) are highly conserved transmembrane glycoproteins that possess pleiotropic functions. Neuropilin-1 (NRP1) and its homologue neuropilin-2 interact as coreceptors with both class 3 semaphorins and vascular endothelial growth factor and are involved in neuronal guidance and angiogenesis, respectively.
openaire   +2 more sources

Semaphorin 3F Serves as a Tumor Suppressor in Esophageal Squamous Cell Carcinoma and is Associated With Lymph Node Metastasis in Disease Progression

Technology in Cancer Research & Treatment, 2020
Background: Esophageal squamous cell carcinoma is one of the leading aggressive malignancies with high mortality. Semaphorin 3F has been reported to be involved in lymphangiogenesis by interacting the vascular endothelial growth factor C/neuropilin 2 ...
Zhen Xie MD, Tianyue Li MD, Bingtao Huang MM, Shuai Liu MM, Lianguo Zhang MM, Qingguang Zhang MD   +5 more
doaj   +1 more source