A dual binding mode for RhoGTPases in plexin signalling.
PLoS Biology, 2011 Plexins are cell surface receptors for the semaphorin family of cell guidance cues. The cytoplasmic region comprises a Ras GTPase-activating protein (GAP) domain and a RhoGTPase binding domain.
Christian H Bell +3 more
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Sema4A Protects Against Muscle Atrophy and Promotes Repair by Regulating Intracellular Metabolic Signalling. [PDF]
J Cachexia Sarcopenia MuscleABSTRACT Background Skeletal muscle atrophy is a debilitating condition associated with diverse diseases and clinical interventions. Although triggers such as glucocorticoid excess or direct muscle injury disrupt the balance between protein homeostasis and tissue repair, the upstream molecular signals that actively preserve muscle integrity remain ...
Wang C +10 more
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Evolution and Diversity of Semaphorins and Plexins in Choanoflagellates [PDF]
Genome Biology and Evolution, 2021 Abstract Semaphorins and plexins are cell surface ligand/receptor proteins that affect cytoskeletal dynamics in metazoan cells. Interestingly, they are also present in Choanoflagellata, a class of unicellular heterotrophic flagellates that forms the phylogenetic sister group to Metazoa. Several members of choanoflagellates are capable of
Chrystian Junqueira Alves +7 more
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Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation. [PDF]
PLoS ONE, 2011 Plexins are cell surface receptors widely studied in the nervous system, where they mediate migration and morphogenesis though the Rho family of small GTPases.
Kelly E Roney +11 more
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The IκB kinase complex is required for plexin-B-mediated activation of RhoA. [PDF]
PLoS ONE, 2014 Plexins are widely expressed transmembrane proteins that mediate the cellular effects of semaphorins. The molecular mechanisms of plexin-mediated signal transduction are still poorly understood.
Matthias Zielonka +3 more
doaj +1 more source
Semaphorin 4D Induces Vasculogenic Differentiation of Dental Pulp Stem Cells
Dentistry Journal, 2023 This work aimed to evaluate the effect of Semaphorin 4D (SEMA4D) signaling through Plexin B1 on the vasculogenic differentiation of dental pulp stem cells.
Najla Al Turkestani +2 more
doaj +1 more source
Nanobody inhibitors of Plexin-B1 identify allostery in plexin–semaphorin interactions and signaling
Journal of Biological Chemistry, 2023 Plexin-B1 is a receptor for the cell surface semaphorin, Sema4D. This signaling system has been implicated in a variety of human diseases, including cancer, multiple sclerosis and osteoporosis. While inhibitors of the Plexin-B1:Sema4D interaction have been previously reported, understanding their mechanism has been hindered by an incomplete structural ...
Richard Cowan +9 more
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Plexin-B1 silencing inhibits ovarian cancer cell migration and invasion
BMC Cancer, 2010 Background Elevated Plexin-B1 expression has been found in diverse human cancers and in non-neoplastic tissues, and it mediates diverse biological and pathological activities.
Zhang Yiqun +15 more
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SOX4 transcriptionally regulates multiple SEMA3/plexin family members and promotes tumor growth in pancreatic cancer. [PDF]
PLoS ONE, 2012 Semaphorin signaling through Plexin frequently participates in tumorigenesis and malignant progression in various types of cancer. In particular, the role of semaphorin signaling in pancreatic ductal adenocarcinoma (PDAC) remains unexplored, despite a ...
Hsin-Yi Huang +6 more
doaj +1 more source
Semaphorins and Plexins in Kidney Disease [PDF]
Nephron, 2016 Semaphorins are soluble or membrane-bound cues, which control multiple aspects of cell-cell communication, differentiation, morphology and function. Most of their effects are mediated by a family of transmembrane receptors called plexins. Semaphorins and plexins have emerged as central regulators of diverse physiological and pathophysiological ...
Xia , J., Worzfeld, T.
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