Results 11 to 20 of about 7,658 (197)

Nanobody inhibitors of Plexin-B1 identify allostery in plexin–semaphorin interactions and signaling

Journal of Biological Chemistry, 2023
Plexin-B1 is a receptor for the cell surface semaphorin, Sema4D. This signaling system has been implicated in a variety of human diseases, including cancer, multiple sclerosis and osteoporosis. While inhibitors of the Plexin-B1:Sema4D interaction have been previously reported, understanding their mechanism has been hindered by an incomplete structural ...
Richard Cowan, Martina Trokter, Arkadiusz Oleksy, Marina Fedorova, Kovilen Sawmynaden, Thomas Worzfeld, Stefan Offermanns, David Matthews, Mark D. Carr, Gareth Hall   +9 more
core   +5 more sources

A dual binding mode for RhoGTPases in plexin signalling. [PDF]

PLoS Biology, 2011
Plexins are cell surface receptors for the semaphorin family of cell guidance cues. The cytoplasmic region comprises a Ras GTPase-activating protein (GAP) domain and a RhoGTPase binding domain.
Christian H Bell, A Radu Aricescu, E Yvonne Jones, Christian Siebold   +3 more
doaj   +6 more sources

Plexin-B1 silencing inhibits ovarian cancer cell migration and invasion [PDF]

BMC Cancer, 2010
Background Elevated Plexin-B1 expression has been found in diverse human cancers and in non-neoplastic tissues, and it mediates diverse biological and pathological activities.
Zhang Yiqun, You Lanying, Chen Yin, Ji Li, Jiang Xuefeng, Zhou Li, Wang Yongjun, Wei Juncheng, Wu Mingfu, Zhou Ting, Hao Xing, Ye Shuangmei, Xu Gang, Zhou Jianfeng, Ma Ding, Wang Shixuan   +15 more
doaj   +3 more sources

PLXNB1 (plexin B1) [PDF]

Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011
Review on PLXNB1 (plexin B1), with data on DNA, on the protein encoded, and where the gene is implicated.
Gómez-Román, JJ, Nicolas, Martínez M, Lazuén, Fernández S, Val-Bernal, JF   +3 more
openaire   +3 more sources

Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation. [PDF]

PLoS ONE, 2011
Plexins are cell surface receptors widely studied in the nervous system, where they mediate migration and morphogenesis though the Rho family of small GTPases.
Kelly E Roney, Brian P O'Connor, Haitao Wen, Eda K Holl, Elizabeth H Guthrie, Beckley K Davis, Stephen W Jones, Sushmita Jha, Lisa Sharek, Rafael Garcia-Mata, James E Bear, Jenny P-Y Ting   +11 more
doaj   +3 more sources

Plexin-B2, But Not Plexin-B1, Critically Modulates Neuronal Migration and Patterning of the Developing Nervous System In Vivo [PDF]

Journal of Neuroscience, 2007
Semaphorins and their receptors, plexins, have emerged as important cellular cues regulating key developmental processes. B-type plexins directly regulate the actin cytoskeleton in a variety of cell types. Recently, B-type plexins have been shown to be expressed in striking patterns in the nervous system over critical developmental windows. However, in
Deng, S, Hirschberg, A, Worzfeld, T, Penachioni, J Y, Korostylev, A, Swiercz, J M, Vodrazka, P, Mauti, O, Stoeckli, E T, Tamagnone, L, Offermanns, S, Kuner, R   +11 more
openaire   +5 more sources

Genetic dissection of plexin signaling in vivo [PDF]

Proceedings of the National Academy of Sciences, 2014
Significance Plexins, a family of transmembrane receptors for semaphorins, control diverse biological processes during mouse development. However, it is largely unknown through which signaling pathways they exert their functions in vivo.
Worzfeld, T., Swiercz, J., Senturk, A., Genz, B., Korostylev, A., Deng, S., Xia, J., Hoshino, M., Epstein, J., Chan, A., Vollmar, B., Acker-Palmer, A., Kuner, R., Offermanns, S.   +13 more
openaire   +4 more sources

Plexin C1 Marks Liver Cancer Cells with Epithelial Phenotype and Is Overexpressed in Hepatocellular Carcinoma

Canadian Journal of Gastroenterology and Hepatology, 2018
Background and Aims. Hepatocellular carcinoma is an aggressive malignancy of the liver and is ranked as the sixth most common cancer worldwide. There is still room for novel markers to improve the diagnosis and monitoring of HCC.
Gorkem Odabas, Metin Cetin, Serdar Turhal, Huseyin Baloglu, A. Emre Sayan, Tamer Yagci   +5 more
doaj   +2 more sources

Plexin‐B3 is a functional receptor for semaphorin 5A [PDF]

EMBO reports, 2004
Semaphorins are a large family of molecular cues implicated in neural development and in a variety of functions outside the nervous system. Semaphorin 5A (Sema5A) is a transmembrane semaphorin, containing seven thrombospondin type‐1 repeats, which was recently found to control axon guidance.
Artigiani, Stefania, Conrotto, Paolo, Fazzari, Pietro, Gilestro, Giorgio F., Barberis, Davide, Giordano, Silvia, Comoglio, Paolo M., Tamagnone, Luca   +7 more
openaire   +3 more sources

Plexin B3 guides axons to cross the midline in vivo [PDF]

Frontiers in Cellular Neuroscience
During the development of neural circuits, axons are guided by a variety of molecular cues to navigate through the brain and establish precise connections with correct partners at the right time and place. Many axon guidance cues have been identified and
Zhi-Zhi Liu, Zhi-Zhi Liu, Zhi-Zhi Liu, Zhi-Zhi Liu, Ling-Yan Liu, Ling-Yan Liu, Ling-Yan Liu, Ling-Yan Liu, Lou-Yin Zhu, Lou-Yin Zhu, Jian Zhu, Jian Zhu, Jia-Yu Luo, Jia-Yu Luo, Jia-Yu Luo, Jia-Yu Luo, Ye-Fan Wang, Ye-Fan Wang, Hong A. Xu, Hong A. Xu, Hong A. Xu, Hong A. Xu   +21 more
doaj   +2 more sources