Results 11 to 20 of about 2,043 (169)
Plexin-B2 and Plexin-D1 in dendritic cells: expression and IL-12/IL-23p40 production. [PDF]
PLoS ONE, 2012 Plexins are a family of genes (A,B,C, and D) that are expressed in many organ systems. Plexins expressed in the immune system have been implicated in cell movement and cell-cell interaction during the course of an immune response.
Eda K Holl +8 more
doaj +5 more sources
A dual binding mode for RhoGTPases in plexin signalling.
PLoS Biology, 2011 Plexins are cell surface receptors for the semaphorin family of cell guidance cues. The cytoplasmic region comprises a Ras GTPase-activating protein (GAP) domain and a RhoGTPase binding domain.
Christian H Bell +3 more
doaj +5 more sources
Nanobody inhibitors of Plexin-B1 identify allostery in plexin-semaphorin interactions and signaling. [PDF]
J Biol Chem, 2023 Plexin-B1 is a receptor for the cell surface semaphorin, Sema4D. This signaling system has been implicated in a variety of human diseases, including cancer, multiple sclerosis and osteoporosis. While inhibitors of the Plexin-B1:Sema4D interaction have been previously reported, understanding their mechanism has been hindered by an incomplete structural ...
Cowan R +9 more
europepmc +3 more sources
The IκB kinase complex is required for plexin-B-mediated activation of RhoA. [PDF]
PLoS ONE, 2014 Plexins are widely expressed transmembrane proteins that mediate the cellular effects of semaphorins. The molecular mechanisms of plexin-mediated signal transduction are still poorly understood.
Matthias Zielonka +3 more
doaj +1 more source
Semaphorins in Angiogenesis and Autoimmune Diseases: Therapeutic Targets?
Frontiers in Immunology, 2020 The axonal guidance molecules, semaphorins, have been described to function both physiologically and pathologically outside of the nervous system. In this review, we focus on the vertebrate semaphorins found in classes 3 through 7 and their roles in ...
Vijaya Iragavarapu-Charyulu +2 more
doaj +1 more source
Mechanochemical control of epidermal stem cell divisions by B-plexins
Nature Communications, 2021 It is unclear how epithelial tissues adjust cell division rates to cell density. Here, the authors show that Plexin-B1 and Plexin-B2 sense mechanical compression (crowding) of epidermal stem cells, resulting in inactivation of YAP and suppression of cell
Chen Jiang +21 more
doaj +1 more source
Evolution and Diversity of Semaphorins and Plexins in Choanoflagellates [PDF]
Genome Biology and Evolution, 2021 Abstract Semaphorins and plexins are cell surface ligand/receptor proteins that affect cytoskeletal dynamics in metazoan cells. Interestingly, they are also present in Choanoflagellata, a class of unicellular heterotrophic flagellates that forms the phylogenetic sister group to Metazoa. Several members of choanoflagellates are capable of
Chrystian Junqueira Alves +7 more
openaire +2 more sources
Plexin-B2 negatively regulates macrophage motility, Rac, and Cdc42 activation. [PDF]
PLoS ONE, 2011 Plexins are cell surface receptors widely studied in the nervous system, where they mediate migration and morphogenesis though the Rho family of small GTPases.
Kelly E Roney +11 more
doaj +1 more source
SEMAPHORINS and their receptors: focus on the crosstalk between melanoma and hypoxia
Journal of Experimental & Clinical Cancer Research, 2021 Hypoxia, a condition of oxygen deprivation, is considered a hallmark of tumor microenvironment regulating several pathways and promoting cancer progression and resistance to therapy.
Elisabetta Valentini +3 more
doaj +1 more source
Frontiers in Immunology, 2021 Semaphorins are a group of proteins that have been studied extensively for their critical function in neuronal development. They have been shown to regulate airway development, tumorigenesis, autoimmune diseases, and the adaptive immune response. Notably,
Shreya M. Kanth +2 more
doaj +1 more source