Results 11 to 20 of about 2,365 (188)
Semaphorins and Plexins in Kidney Disease [PDF]
Nephron, 2016 Semaphorins are soluble or membrane-bound cues, which control multiple aspects of cell-cell communication, differentiation, morphology and function. Most of their effects are mediated by a family of transmembrane receptors called plexins. Semaphorins and plexins have emerged as central regulators of diverse physiological and pathophysiological ...
Xia , J., Worzfeld, T.
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Mechanochemical control of epidermal stem cell divisions by B-plexins [PDF]
Nature Communications, 2021 It is unclear how epithelial tissues adjust cell division rates to cell density. Here, the authors show that Plexin-B1 and Plexin-B2 sense mechanical compression (crowding) of epidermal stem cells, resulting in inactivation of YAP and suppression of cell
Chen Jiang +21 more
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Functions of Plexins/Neuropilins and Their Ligands during Hippocampal Development and Neurodegeneration [PDF]
Cells, 2019 There is emerging evidence that molecules, receptors, and signaling mechanisms involved in vascular development also play crucial roles during the development of the nervous system.
Vanessa Gil, José Antonio del Río
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Structural Basis for Plexin Activation and Regulation [PDF]
Neuron, 2016 Class A plexins (PlxnAs) act as semaphorin receptors and control diverse aspects of nervous system development and plasticity, ranging from axon guidance and neuron migration to synaptic organization. PlxnA signaling requires cytoplasmic domain dimerization, but extracellular regulation and activation mechanisms remain unclear.
Kong, Youxin +10 more
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Plexins function in epithelial repair in both Drosophila and zebrafish [PDF]
Nature Communications, 2016 Plexins are semaphorin receptors and are well known for their roles in neuronal pathfinding. Here the authors describe a role for Plexin A in healing damaged epithelia in Drosophila and zebrafish. In Drosophila, Plexin A inhibits the GTPase Rap1 to allow
Sa Kan Yoo +6 more
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Plexin-B2 and Plexin-D1 in dendritic cells: expression and IL-12/IL-23p40 production. [PDF]
PLoS ONE, 2012 Plexins are a family of genes (A,B,C, and D) that are expressed in many organ systems. Plexins expressed in the immune system have been implicated in cell movement and cell-cell interaction during the course of an immune response.
Eda K Holl +8 more
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Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin
BMC Neuroscience, 2005 Background Plexins, known to date as receptors of semaphorins, are implicated in semaphorin-mediated axon repulsion and growth cone collapse. However, subtype-specific functions of the majority of the nine members of the mammalian plexin family are ...
Rosenberger Georg +4 more
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Developmental Biology, 2008 During development, the semaphorin family of guidance molecules is required for proper formation of the sympathetic nervous system. Plexins are receptors that mediate semaphorin signaling, but how plexins function during sympathetic development is not fully understood. Using phenotypic analyses of mutant mice in vivo, expression pattern studies, and in
Waimey, Kathryn E. +3 more
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Genetic dissection of plexin signaling in vivo [PDF]
Proceedings of the National Academy of Sciences, 2014 Significance Plexins, a family of transmembrane receptors for semaphorins, control diverse biological processes during mouse development. However, it is largely unknown through which signaling pathways they exert their functions in vivo.
Worzfeld, T. +13 more
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