Results 41 to 50 of about 2,365 (188)

Cryo-EM structure of the PlexinC1/A39R complex reveals inter-domain interactions critical for ligand-induced activation

Nature Communications, 2020
Plexins are the receptors for the guidance molecules semaphorins and regulate immunity and the development of the nervous and cardiovascular systems. Here authors present a structure of full-length human PlexinC1 in complex with its ligand A39R, which ...
Yi-Chun Kuo, Hua Chen, Guijun Shang, Emiko Uchikawa, Hui Tian, Xiao-Chen Bai, Xuewu Zhang   +6 more
doaj   +1 more source

Structural basis for activation and non-canonical catalysis of the Rap GTPase activating protein domain of plexin

eLife, 2013
Plexins are cell surface receptors that bind semaphorins and transduce signals for regulating neuronal axon guidance and other processes. Plexin signaling depends on their cytoplasmic GTPase activating protein (GAP) domain, which specifically inactivates
Yuxiao Wang, Heath G Pascoe, Chad A Brautigam, Huawei He, Xuewu Zhang   +4 more
doaj   +1 more source

Axon guidance molecules in immunometabolic diseases

Inflammation and Regeneration, 2022
The global prevalence of metabolic diseases, such as obesity, diabetes, and atherosclerosis, is rapidly increasing and has now reached epidemic proportions.
Yoshimitsu Nakanishi, Sujin Kang, Atsushi Kumanogoh   +2 more
doaj   +1 more source

A putative structural mechanism underlying the antithetic effect of homologous RND1 and RhoD GTPases in mammalian plexin regulation

eLife, 2021
Plexins are semaphorin receptors that play essential roles in mammalian neuronal axon guidance and in many other important mammalian biological processes.
Yanyan Liu, Pu Ke, Yi-Chun Kuo, Yuxiao Wang, Xuewu Zhang, Chen Song, Yibing Shan   +6 more
doaj   +1 more source

Functional divergence of Plexin B structural motifs in distinct steps of Drosophila olfactory circuit assembly

eLife, 2019
Plexins exhibit multitudinous, evolutionarily conserved functions in neural development. How Plexins employ their diverse structural motifs in vivo to perform distinct roles is unclear. We previously reported that Plexin B (PlexB) controls multiple steps
Ricardo Guajardo, David J Luginbuhl, Shuo Han, Liqun Luo, Jiefu Li   +4 more
doaj   +1 more source

Origin and evolution of plexins, semaphorins, and Met receptor tyrosine kinases [PDF]

, 2019
The transition from unicellular to multicellular organisms poses the question as to when genes that regulate cell-cell interactions emerged during evolution.
Zou, Hongyan, Alves, Chrystian Junqueira, Friedel, Roland H., Yotoko, Karla   +3 more
core   +1 more source

Mind the (guidance) signals! Translational relevance of semaphorins, plexins, and neuropilins in pancreatic cancer

, 2023
Pancreatic cancer is a major cause of demise worldwide. Although key associated genetic changes have been discovered, disease progression is sustained by pathogenic mechanisms that are poorly understood at the molecular level.
Luca Tamagnone
core   +1 more source

Recruitment of Tiam1 to Semaphorin 4D Activates Rac and Enhances Proliferation, Invasion, and Metastasis in Oral Squamous Cell Carcinoma

Neoplasia: An International Journal for Oncology Research, 2017
The semaphorins and the plexins are a family of large, cysteine-rich proteins originally identified as regulators of axon growth and lymphocyte activation that are now known to provide motility and positional information for a number of cell and tissue ...
Hua Zhou, Maricel G. Kann, Emily K. Mallory, Ying-Hua Yang, Amr Bugshan, Nada O. Binmadi, John R. Basile   +6 more
doaj   +1 more source

PlexinA1 Autoinhibition by the Plexin Sema Domain [PDF]

Neuron, 2001
Semaphorin 3A (Sema3A) binds to neuropilin-1 (NP1) and activates the transmembrane Plexin to transduce a repulsive axon guidance signal. Here, we show that Sema3 signals are transduced equally effectively by PlexinA1 or PlexinA2, but not by PlexinA3.
Takahashi, Takuya, Strittmatter, Stephen M   +1 more
openaire   +2 more sources

Plexin-B1 mutations in prostate cancer [PDF]

Proceedings of the National Academy of Sciences, 2007
Semaphorins are a large class of secreted or membrane-associated proteins that act as chemotactic cues for cell movement via their transmembrane receptors, plexins. We hypothesized that the function of the semaphorin signaling pathway in the control of cell migration could be harnessed by cancer cells during invasion and metastasis.
Oscar Gee-Wan, Wong, Tharani, Nitkunan, Izumi, Oinuma, Chun, Zhou, Veronique, Blanc, Richard S D, Brown, Simon R J, Bott, Joseph, Nariculam, Gary, Box, Phillipa, Munson, Jason, Constantinou, Mark R, Feneley, Helmut, Klocker, Suzanne A, Eccles, Manabu, Negishi, Alex, Freeman, John R, Masters, Magali, Williamson   +17 more
openaire   +2 more sources