Results 61 to 70 of about 2,365 (188)

Synchronizing the Osteochondral Regeneration Process through Spatial Patterning of Stable and Hypertrophic Cartilage Organoids

Advanced Materials, Volume 38, Issue 33, 12 June 2026.
Zonated osteochondral assembloid implants are engineered through scaffold‐free spatial assembly of induced pluripotent stem cell (iPSC)‐derived chondrocyte organoids and periosteum‐derived osteogenic organoids. Implanted into full‐thickness rat osteochondral defects, they promote hyaline‐like cartilage repair, support subchondral bone formation with ...
Liuqi Peng, Isaak Decoene, Hanna Svitina, Ioannis Papantoniou   +3 more
wiley   +1 more source

Different Requirement for Rnd GTPases of R-Ras GAP Activity of Plexin-C1 and Plexin-D1 [PDF]

Journal of Biological Chemistry, 2009
Plexins, comprising Plexin-A, -B, -C, and -D subfamilies, are receptors for semaphorins governing cell adhesion, migration, and axon guidance. Among plexin subfamilies, Plexin-A1 and Plexin-B1 have been shown to function as an R-Ras GAP, inducing repulsive responses, and the expression of R-Ras GAP activity requires the binding of Rnd1, a member of Rnd
Kanami, Uesugi, Izumi, Oinuma, Hironori, Katoh, Manabu, Negishi   +3 more
openaire   +2 more sources

Spatial transcriptomics reveals a new cluster of fibroblasts to promote the progression of lung adenocarcinoma

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
1. Spatial transcriptomics reveals two types of colocation patterns between lung cancer cells and fibroblasts in LUAD. SPP1+ TM4SF4+ epithelial cells and COL+ fibroblasts were co‐located in a highly malignant region, while SFTPC+ epithelial cells and DCN+ fibroblasts were in a low malignant region. 2.
Liyang Li, Xiaoxia Liu, Yifei Liu, Xuanqi Liu, Wanxin Duan, Yujia Jiang, Jian Chen, Tianxiang Chen, Gang Chen, Ao Chen, Duojiao Wu, Dongli Song, Yuanlin Song   +12 more
wiley   +1 more source

Epigenetic Aging in Brain Tissue of the Self‐Fertilizing Vertebrate, Kryptolebias marmoratus

Ecology and Evolution, Volume 16, Issue 6, June 2026.
Using the self‐fertilizing vertebrate Kryptolebias marmoratus, we developed an epigenetic clock from brain tissue that predicts chronological age with high accuracy, demonstrating that DNA methylation changes consistently with age even in the near absence of genetic variation. The 40 age‐associated CpG sites identified map to genes with conserved roles
Justine Bélik, Frédéric Silvestre
wiley   +1 more source

Plexin-mediated neuronal development and neuroinflammatory responses in the nervous system [PDF]

, 2023
Plexins are a large family of single-pass transmembrane proteins that mediate semaphorin signaling in multiple systems. Plexins were originally characterized for their role modulating cytoskeletal activity to regulate axon guidance during nervous system ...
Dai, Lu, Zhang, Chun-Qing, Shen, Kai-Feng   +2 more
core   +1 more source

Glial and neuronal Semaphorin signaling instruct the development of a functional myotopic map for Drosophila walking

eLife, 2016
Motoneurons developmentally acquire appropriate cellular architectures that ensure connections with postsynaptic muscles and presynaptic neurons. In Drosophila, leg motoneurons are organized as a myotopic map, where their dendritic domains represent the ...
Durafshan Sakeena Syed, Swetha B.M. Gowda, O Venkateswara Reddy, Heinrich Reichert, K VijayRaghavan   +4 more
doaj   +1 more source

Glial receptor PLXNB2 regulates schizophrenia-related stress perception via the amygdala

Frontiers in Immunology, 2022
Stress is a trigger for the development of psychiatric disorders. However, how stress trait differs in schizophrenia patients is still unclear. Stress also induces and exacerbates immune activation in psychiatric disorders. Plexins (Plxn) and its ligands
Fang-Ling Xuan, Ling Yan, Yanli Li, Fengmei Fan, Hu Deng, Mengzhuang Gou, Keerthana Chithanathan, Indrek Heinla, Liang Yuan, Kadri Seppa, Alexander Zharkovsky, Anti Kalda, L. Elliot Hong, Guo-Fu Hu, Yunlong Tan, Li Tian   +15 more
doaj   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development

Developmental Biology, 2008
In vertebrates, class 3 semaphorins (SEMA3) control axon behaviour by binding to neuronal cell surface receptors composed of a ligand binding subunit termed neuropilin (NRP) and a signal transduction subunit of the A-type plexin family (PLXNA). We have determined the requirement for SEMA3/NRP/PLXN signalling in the development of the facial nerve ...
Schwarz, Quenten, Waimey, Kathryn E., Golding, Matthew, Takamatsu, Hyota, Kumanogoh, Atsushi, Fujisawa, Hajime, Cheng, Hwai-Jong, Ruhrberg, Christiana   +7 more
openaire   +2 more sources

Plexin‐B3 is a functional receptor for semaphorin 5A [PDF]

EMBO reports, 2004
Semaphorins are a large family of molecular cues implicated in neural development and in a variety of functions outside the nervous system. Semaphorin 5A (Sema5A) is a transmembrane semaphorin, containing seven thrombospondin type‐1 repeats, which was recently found to control axon guidance.
Artigiani, Stefania, Conrotto, Paolo, Fazzari, Pietro, Gilestro, Giorgio F., Barberis, Davide, Giordano, Silvia, Comoglio, Paolo M., Tamagnone, Luca   +7 more
openaire   +2 more sources