Results 61 to 70 of about 2,043 (169)

Plexin-A3 and plexin-A4 restrict the migration of sympathetic neurons but not their neural crest precursors

Developmental Biology, 2008
During development, the semaphorin family of guidance molecules is required for proper formation of the sympathetic nervous system. Plexins are receptors that mediate semaphorin signaling, but how plexins function during sympathetic development is not fully understood. Using phenotypic analyses of mutant mice in vivo, expression pattern studies, and in
Waimey, Kathryn E., Huang, Pei-Hsin, Chen, Maggie, Cheng, Hwai-Jong   +3 more
openaire   +2 more sources

Role of Neuropilin 1 in COVID-19 Patients with Acute Ischemic Stroke

Biomedicines, 2022
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection can trigger the adaptive and innate immune responses, leading to uncontrolled inflammatory reactions and associated local and systematic tissue damage, along with thromboembolic ...
Asma W. Al-Thomali, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Ali K. Al-buhadiliy, Michel De Waard, Jean-Marc Sabatier, Atif Ali Khan Khalil, Hebatallah M. Saad, Gaber El-Saber Batiha   +8 more
doaj   +1 more source

Patients With B3GALT6‐Linkeropathies Display Sialylated Disaccharides as Truncated Glycosaminoglycan Linkage Regions of Specific Core Proteins

Proteoglycan Research, Volume 4, Issue 3, July 2026.
ABSTRACT The Ehlers–Danlos syndromes (EDS) are a group of heritable connective tissue disorders, characterized by varying degrees of joint hypermobility, skin hyperextensibility and extracellular matrix defects. Spondylodysplastic type of EDS (spEDS) is a rare type of this group that can be caused by pathogenic variants in the B3GALT6 gene, coding for ...
Noborn Fredrik, Nilsson Jonas, Blomqvist Maria, Syx Delfien, Mendoza‐Londono Roberto, Malfait Fransiska, Larson Göran   +6 more
wiley   +1 more source

Proteolytic remodelling of the extracellular matrix by pericytes

The FEBS Journal, Volume 293, Issue 13, Page 3899-3953, July 2026.
Pericytes are specialised perivascular cells intimately connected with endothelial cells and essential for the maintenance of vascular beds. They contribute to the formation and remodelling of the extracellular matrix by actively secreting proteases and protease inhibitors.
Tina Burkhard, Ella Milne, Kate Qian, Paola Campagnolo, Salvatore Santamaria   +4 more
wiley   +1 more source

Plexin A3 and plexin A4 convey semaphorin signals during facial nerve development

Developmental Biology, 2008
In vertebrates, class 3 semaphorins (SEMA3) control axon behaviour by binding to neuronal cell surface receptors composed of a ligand binding subunit termed neuropilin (NRP) and a signal transduction subunit of the A-type plexin family (PLXNA). We have determined the requirement for SEMA3/NRP/PLXN signalling in the development of the facial nerve ...
Schwarz, Quenten, Waimey, Kathryn E., Golding, Matthew, Takamatsu, Hyota, Kumanogoh, Atsushi, Fujisawa, Hajime, Cheng, Hwai-Jong, Ruhrberg, Christiana   +7 more
openaire   +2 more sources

Plexin‐B3 is a functional receptor for semaphorin 5A [PDF]

The EMBO Reports, 2004
Semaphorins are a large family of molecular cues implicated in neural development and in a variety of functions outside the nervous system. Semaphorin 5A (Sema5A) is a transmembrane semaphorin, containing seven thrombospondin type-1 repeats, which was recently found to control axon guidance.
Artigiani, Stefania, Conrotto, Paolo, Fazzari, Pietro, Gilestro, Giorgio F., Barberis, Davide, Giordano, Silvia, Comoglio, Paolo M., Tamagnone, Luca   +7 more
openaire   +2 more sources

Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer. [PDF]

PLoS ONE, 2016
Bone density is controlled by interactions between osteoclasts, which resorb bone, and osteoblasts, which deposit it. The semaphorins and their receptors, the plexins, originally shown to function in the immune system and to provide chemotactic cues for ...
Ying-Hua Yang, Asma Buhamrah, Abraham Schneider, Yi-Ling Lin, Hua Zhou, Amr Bugshan, John R Basile   +6 more
doaj   +1 more source

Synchronizing the Osteochondral Regeneration Process through Spatial Patterning of Stable and Hypertrophic Cartilage Organoids

Advanced Materials, Volume 38, Issue 33, 12 June 2026.
Zonated osteochondral assembloid implants are engineered through scaffold‐free spatial assembly of induced pluripotent stem cell (iPSC)‐derived chondrocyte organoids and periosteum‐derived osteogenic organoids. Implanted into full‐thickness rat osteochondral defects, they promote hyaline‐like cartilage repair, support subchondral bone formation with ...
Liuqi Peng, Isaak Decoene, Hanna Svitina, Ioannis Papantoniou   +3 more
wiley   +1 more source

A cytosolic juxtamembrane interface modulates plexin A3 oligomerization and signal transduction. [PDF]

PLoS ONE, 2015
Plexins (plxns) are transmembrane (TM) receptors involved in the guidance of vascular, lymphatic vessel, and neuron growth as well as cancer metastasis.
Rachael Barton, Danica Palacio, M Kathryn Iovine, Bryan W Berger   +3 more
doaj   +1 more source

Spatial transcriptomics reveals a new cluster of fibroblasts to promote the progression of lung adenocarcinoma

Clinical and Translational Discovery, Volume 6, Issue 3, June 2026.
1. Spatial transcriptomics reveals two types of colocation patterns between lung cancer cells and fibroblasts in LUAD. SPP1+ TM4SF4+ epithelial cells and COL+ fibroblasts were co‐located in a highly malignant region, while SFTPC+ epithelial cells and DCN+ fibroblasts were in a low malignant region. 2.
Liyang Li, Xiaoxia Liu, Yifei Liu, Xuanqi Liu, Wanxin Duan, Yujia Jiang, Jian Chen, Tianxiang Chen, Gang Chen, Ao Chen, Duojiao Wu, Dongli Song, Yuanlin Song   +12 more
wiley   +1 more source