Results 71 to 80 of about 2,043 (169)

Epigenetic Aging in Brain Tissue of the Self‐Fertilizing Vertebrate, Kryptolebias marmoratus

Ecology and Evolution, Volume 16, Issue 6, June 2026.
Using the self‐fertilizing vertebrate Kryptolebias marmoratus, we developed an epigenetic clock from brain tissue that predicts chronological age with high accuracy, demonstrating that DNA methylation changes consistently with age even in the near absence of genetic variation. The 40 age‐associated CpG sites identified map to genes with conserved roles
Justine Bélik, Frédéric Silvestre
wiley   +1 more source

Semaphorin signaling in vertebrate neural circuit assembly

Frontiers in Molecular Neuroscience, 2012
Neural circuit formation requires the coordination of many complex developmental processes. First, neurons project axons over long distances to find their final targets and then establish appropriate connectivity essential for the formation of neuronal ...
Yutaka eYoshida
doaj   +1 more source

Aspartame Increases the Risk of Pancreatic Ductal Adenocarcinoma

eFood, Volume 7, Issue 3, June 2026.
Aspartame (APM) is a widely used artificial sweetener associated with various health concerns, including potential links to diabetes, cardiovascular diseases, and an increased risk of cancer. A comprehensive approach incorporating data mining, machine learning, network toxicology, molecular docking, molecular dynamics simulations, and clinical sample ...
Jumin Xie, Wei Fang, Zean Song, Zhang Yu, Ying Zhu, Shaoping Liu   +5 more
wiley   +1 more source

Plexin-B2, But Not Plexin-B1, Critically Modulates Neuronal Migration and Patterning of the Developing Nervous System In Vivo [PDF]

Journal of Neuroscience, 2007
Semaphorins and their receptors, plexins, have emerged as important cellular cues regulating key developmental processes. B-type plexins directly regulate the actin cytoskeleton in a variety of cell types. Recently, B-type plexins have been shown to be expressed in striking patterns in the nervous system over critical developmental windows. However, in
Deng, S, Hirschberg, A, Worzfeld, T, Penachioni, J Y, Korostylev, A, Swiercz, J M, Vodrazka, P, Mauti, O, Stoeckli, E T, Tamagnone, L, Offermanns, S, Kuner, R   +11 more
openaire   +3 more sources

c-Met and Other Cell Surface Molecules: Interaction, Activation and Functional Consequences

Biomedicines, 2015
The c-Met receptor, also known as the HGF receptor, is one of the most studied tyrosine kinase receptors, yet its biological functions and activation mechanisms are still not fully understood.
Giuditta Viticchiè, Patricia A. J. Muller   +1 more
doaj   +1 more source

c‐Met‐Targeted Imaging Agents: Progress and Challenges

iRADIOLOGY, Volume 4, Issue 3, Page 219-245, June 2026.
This review summarizes recent advances in c‐Met‐targeted imaging probes, including hepatocyte growth factor (HGF) ligands, antibodies, peptides, and small molecules across magnetic resonance imaging (MRI), positron emission tomography (PET), single‐photon emission computed tomography (SPECT), and optical imaging modalities.
Yonghao Li, Aiyan Ji, Qihang Ding, Hongyue Lou, Zhen Cheng   +4 more
wiley   +1 more source

Cloning, expression pattern, and potential role of MAPKp38 and NF-κBp65 in response to lipopolysaccharide in yellow catfish (Pelteobagrus fulvidraco)

Animal Nutrition, 2019
Mitogen-activated protein kinases (MAPK) and nuclear factor kappa B (NF-κB) pathways are considered to be two crucial intracellular signaling cascades in pro-inflammatory responses.
Dan Shi, Ye Zhao, Lin Feng, Yang Liu, Wei-Dan Jiang, Pei Wu, Juan Zhao, Jun Jiang, Xiao-Qiu Zhou   +8 more
doaj   +1 more source

Sema4A Protects Against Muscle Atrophy and Promotes Repair by Regulating Intracellular Metabolic Signalling

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Skeletal muscle atrophy is a debilitating condition associated with diverse diseases and clinical interventions. Although triggers such as glucocorticoid excess or direct muscle injury disrupt the balance between protein homeostasis and tissue repair, the upstream molecular signals that actively preserve muscle integrity remain ...
Caiyun Wang, Honghong Chen, Lingjie Shen, Shenhan Xu, Jie Xu, Qiuyuan Huang, Weiheng Zhang, Chengshou Lin, Jun Chang, Xinhua Liu, Wugui Chen   +10 more
wiley   +1 more source

Divergent roles of Plexin D1 in cancer

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2019
Plexin D1 belongs to a family of transmembrane proteins called plexins. It was characterized as a receptor for semaphorins and is known to be essential for axonal guidance and vascular patterning. Mutations in Plexin D1 have been implicated in pathologic conditions such as truncus arteriosus and Möbius syndrome.
Sneha, Vivekanadhan, Debabrata, Mukhopadhyay   +1 more
openaire   +3 more sources

Depletion of microglial compensation in glial network: Disease‐associated response dynamics in the revised amyloid hypothesis

Neuroprotection, Volume 4, Issue 2, Page 131-142, June 2026.
The critical transition from amyloid pathology to irreversible neuronal loss in Alzheimer's disease hinges on the microglial response. This review aims to systematize the patterns of how microglia react within the glial context. Abstract Microglia mount coordinated, stage‐dependent compensatory programs in response to early amyloid β (Aβ) accumulation ...
Songtao Lei, Zixuan Huang, Wen Wang, Yan Meng   +3 more
wiley   +1 more source