Results 71 to 80 of about 2,365 (188)

Effect of cancer-associated mutations in the PlexinB1 gene

Molecular Cancer, 2012
Background Semaphorins act as chemotactic cues for cell movement via their transmembrane receptors, plexins. Somatic missense mutations in the plexinB1 gene coupled with overexpression of the protein frequently occur in prostate tumours, indicating a ...
Zhou Chun, Wong Oscar, Masters John R, Williamson Magali   +3 more
doaj   +1 more source

Role of Neuropilin 1 in COVID-19 Patients with Acute Ischemic Stroke

Biomedicines, 2022
Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) infection can trigger the adaptive and innate immune responses, leading to uncontrolled inflammatory reactions and associated local and systematic tissue damage, along with thromboembolic ...
Asma W. Al-Thomali, Hayder M. Al-kuraishy, Ali I. Al-Gareeb, Ali K. Al-buhadiliy, Michel De Waard, Jean-Marc Sabatier, Atif Ali Khan Khalil, Hebatallah M. Saad, Gaber El-Saber Batiha   +8 more
doaj   +1 more source

Depletion of microglial compensation in glial network: Disease‐associated response dynamics in the revised amyloid hypothesis

Neuroprotection, Volume 4, Issue 2, Page 131-142, June 2026.
The critical transition from amyloid pathology to irreversible neuronal loss in Alzheimer's disease hinges on the microglial response. This review aims to systematize the patterns of how microglia react within the glial context. Abstract Microglia mount coordinated, stage‐dependent compensatory programs in response to early amyloid β (Aβ) accumulation ...
Songtao Lei, Zixuan Huang, Wen Wang, Yan Meng   +3 more
wiley   +1 more source

B plexins activate Rho through PDZ-RhoGEF

, 2002
Plexins are receptors for the repulsive axon guidance molecules semaphorins. Previously, we have shown that plexin-B1 binds activated Rac, but that clustering of plexin-B1 causes Rho activation, resulting in stress fiber formation.
Olivo, Cristina, Mariette H.E Driessens, John G Collard, Driessens, Mariette H.E, Masaki Inagaki, Koh-ichi Nagata, Nagata, Koh-ichi, Collard, John G, Inagaki, Masaki, Cristina Olivo   +9 more
core   +1 more source

Plexin-B2, But Not Plexin-B1, Critically Modulates Neuronal Migration and Patterning of the Developing Nervous System In Vivo [PDF]

Journal of Neuroscience, 2007
Semaphorins and their receptors, plexins, have emerged as important cellular cues regulating key developmental processes. B-type plexins directly regulate the actin cytoskeleton in a variety of cell types. Recently, B-type plexins have been shown to be expressed in striking patterns in the nervous system over critical developmental windows. However, in
Deng, S, Hirschberg, A, Worzfeld, T, Penachioni, J Y, Korostylev, A, Swiercz, J M, Vodrazka, P, Mauti, O, Stoeckli, E T, Tamagnone, L, Offermanns, S, Kuner, R   +11 more
openaire   +3 more sources

Biochemical bone biomarkers in plasma cell dyscrasias

British Journal of Haematology, Volume 208, Issue 6, Page 1909-1923, June 2026.
Visual abstract depicting that bone turnover markers reflect dynamic alterations in bone remodelling across the spectrum of plasma cell dyscrasias but remain limited by assay variability, biological confounding and incomplete integration with imaging and risk stratification.
Guido Nador, Rohit Vijjhalwar, Muhammad Kassim Javaid, Claire M. Edwards, Karthik Ramasamy   +4 more
wiley   +1 more source

Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer. [PDF]

PLoS ONE, 2016
Bone density is controlled by interactions between osteoclasts, which resorb bone, and osteoblasts, which deposit it. The semaphorins and their receptors, the plexins, originally shown to function in the immune system and to provide chemotactic cues for ...
Ying-Hua Yang, Asma Buhamrah, Abraham Schneider, Yi-Ling Lin, Hua Zhou, Amr Bugshan, John R Basile   +6 more
doaj   +1 more source

Microglia Mitochondria Support Neuronal Maturation via Metabolic and Transcriptional Reprogramming in Human 3D In Vitro Brain Model

Advanced Science, Volume 13, Issue 25, 4 May 2026.
xx xx. ABSTRACT Autism Spectrum Disorder (ASD) is a neurodevelopmental condition characterized by disrupted neuronal circuit maturation. Emerging evidence implicates microglial function and mitochondrial regulation as contributors to ASD‐associated biology, yet the mechanisms linking these processes to neuronal development remain poorly defined ...
Sydney P. Sterben, Charitha C. Anamala, Sahan B. S. Kansakar, Vaishnavi Koduri, Volha Liaudanskaya   +4 more
wiley   +1 more source

A cytosolic juxtamembrane interface modulates plexin A3 oligomerization and signal transduction. [PDF]

PLoS ONE, 2015
Plexins (plxns) are transmembrane (TM) receptors involved in the guidance of vascular, lymphatic vessel, and neuron growth as well as cancer metastasis.
Rachael Barton, Danica Palacio, M Kathryn Iovine, Bryan W Berger   +3 more
doaj   +1 more source

Tumor‐Derived Exosomal TAGLN2 Promotes Metastasis by Inducing Vascular Permeability and Angiogenesis via the NRP1/SEMA4D/YAP Axis

Advanced Science, Volume 13, Issue 29, 22 May 2026.
Gastric cancer‐derived exosomal TAGLN2 is identified as a key mediator of vascular reprogramming, with significantly elevated levels detected in patient serum. Independent of canonical SEMA4D signaling, it nucleates a cytoplasmic TAGLN2/NRP1/SEMA4D ternary complex that dually activates YAP, promoting angiogenesis, vascular dysfunction, and metastasis ...
Shuqi Yu, Jiajia Zhuo, Xiaoquan Hong, Shihao Rao, Yafang Ye, Dandan Kang, Huifang Peng, Huiqin Zhuo   +7 more
wiley   +1 more source