Results 81 to 90 of about 2,365 (188)
How does type 2 diabetes modify the risk of Alzheimer's disease?
Alzheimer's &Dementia, Volume 22, Issue 5, May 2026.Abstract Type 2 diabetes (T2D) and Alzheimer's disease (AD) are both increasing exponentially worldwide. T2D has also been identified as one of 14 modifiable risk factors for dementia, but the mechanism is unknown. T2D could promote dementia via vascular or AD neuropathological changes, and mechanistic hypotheses include central insulin resistance and ...
G. T. Sutherland +7 more
wiley +1 more source
Evaluating Protein Enrichment Methods to Improve Biomarker Discovery in Equine Cerebrospinal Fluid
Veterinary Medicine and Science, Volume 12, Issue 3, May 2026.Here, we compared two protein enrichment methods—ProteoMiner Small‐Capacity and PreOmics Enrich‐iST—for proteomic analysis of equine cerebrospinal fluid (CSF). PreOmics Enrich‐iST achieved superior depletion of high‐abundance proteins and identified a greater number of low‐abundance, neuropathology‐relevant proteins than ProteoMiner or native digestion.
Foti Federico +5 more
wiley +1 more source
The Activity of the Plexin-A1 Receptor Is Regulated by Rac [PDF]
Journal of Biological Chemistry, 2004 Plexins constitute a large family of transmembrane proteins that act as receptors for the semaphorin family of ligands. They are best known for their role in growth cone guidance, although they also are widely expressed outside the nervous system. Plexins are thought to control axon guidance by modifying the growth cone cytoskeleton, and Rho GTPases ...
Laura J, Turner +2 more
openaire +2 more sources
Semaphorin signaling in vertebrate neural circuit assembly
Frontiers in Molecular Neuroscience, 2012 Neural circuit formation requires the coordination of many complex developmental processes. First, neurons project axons over long distances to find their final targets and then establish appropriate connectivity essential for the formation of neuronal ...
Yutaka eYoshida
doaj +1 more source
Xenotransplantation, Volume 33, Issue 3, May/June 2026.ABSTRACT Xenotransplantation has been iteratively improved over the last decade in pre‐clinical models, with first‐in‐human clinical trials underway. The 2025 IXA Congress in Geneva was held in parallel with meetings involving World Health Organization leaders to support the development of new guidance on xenotransplantation in this rapidly evolving ...
Corbin E. Goerlich +12 more
wiley +1 more source
Divergent roles of Plexin D1 in cancer
Biochimica et Biophysica Acta (BBA) - Reviews on Cancer, 2019 Plexin D1 belongs to a family of transmembrane proteins called plexins. It was characterized as a receptor for semaphorins and is known to be essential for axonal guidance and vascular patterning. Mutations in Plexin D1 have been implicated in pathologic conditions such as truncus arteriosus and Möbius syndrome.
Sneha, Vivekanadhan +1 more
openaire +3 more sources
c-Met and Other Cell Surface Molecules: Interaction, Activation and Functional Consequences
Biomedicines, 2015 The c-Met receptor, also known as the HGF receptor, is one of the most studied tyrosine kinase receptors, yet its biological functions and activation mechanisms are still not fully understood.
Giuditta Viticchiè +1 more
doaj +1 more source
iMeta, Volume 5, Issue 2, April 2026.We utilized single‐cell RNA sequencing (scRNA‐seq) to investigate cellular heterogeneity and signaling networks in aortic dissection (AD) tissues compared to adjacent normal tissues. The analysis identified five smooth muscle cell (SMC) subtypes, with SMC2 linked to fibrosis and SMC3 associated with inflammation.
Liang Shao +12 more
wiley +1 more source
Structural and Functional Studies of Semaphorins and PLexins
, 2007 Semaphorins are a large family of secreted and transmembrane proteins required for guidance of pioneering axons to their predestined targets during neuronal development.
Love, Christopher
core
Animal Nutrition, 2019 Mitogen-activated protein kinases (MAPK) and nuclear factor kappa B (NF-κB) pathways are considered to be two crucial intracellular signaling cascades in pro-inflammatory responses.
Dan Shi +8 more
doaj +1 more source