Results 101 to 110 of about 2,365 (188)

Receptor complexes for each of the Class 3 Semaphorins

Frontiers in Cellular Neuroscience, 2012
The Class 3 Semaphorins (Sema3s) are a sub-family of proteins whose known biological roles are varied and growing. The mechanism of action of the Sema3s requires binding to transmembrane receptors that comprise heteromeric complexes of Neuropilins ...
Alan R Harvey
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Plexin Activation Relies on an Array of Receptors

PLoS Biology, 2011
​YoungYoung nerve cells put out cellular extensions called axons that must navigate through a maze of environmental cues in order to find their targets. Making the correct cellular connections is critical to building a functioning nervous system. In order to interpret these external cues, axons use receptor proteins that are directly embedded in the ...
openaire   +4 more sources

The Role of Plexin-B2 in the Immune System

, 2010
Plexins and semaphorins are a family of transmembrane proteins that mediate diverse roles such as cell-cell contact, cell adhesion, cell movement, and cell response.
Roney, Kelly E.
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The role of the plexin-A2 receptor in semaphorin-3A and semaphorin-3B signal transduction. [PDF]

, 2014
Class-3 semaphorins are anti-angiogenic and anti-tumorigenic guidance factors that bind to neuropilins which in turn associate with class-A plexins to transduce semaphorin signals.
Sabag, A.D., Mumblat, Y., Kessler, O., Smolkin, T., Gloeckner, C.J., Neufeld, G., Ueffing, M.   +6 more
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Semaphorin-4D (Sema-4D), the Plexin-B1 ligand, is involved in mouse ovary follicular development

Reproductive Biology and Endocrinology, 2007
Background Human Plexin-B1 is expressed in two truncated forms. The long form encodes a trans-membranal protein, while the short form, which is bound to the cell surface and partially secreted, possibly serves as a decoy receptor.
Goldman Shlomit, Regev Avital, Shalev Eliezer   +2 more
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The semaphorin 3A receptor may directly regulate the activity of small GTPases

, 2000
The axon guidance signal semaphorin 3A induces the rapid collapse of growth cones by activating a receptor complex that contains neuropilin-1 as the ligand-binding and a plexin as the signal-transducing subunit.
Hovatta, Iiris, Iiris Hovatta, Rahim, Belquis, Beate Rohm, Kleiber, Bedriska, Püschel, Andreas W., Belquis Rahim, Rohm, Beate, Bedriska Kleiber, Andreas W. Püschel   +9 more
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Signalling by semaphorin receptors: Cell guidance and beyond

, 2000
Semaphorins are a large family of secreted or cell-bound signals, known to guide axons in developing nervous tissue. They are expressed in a variety of adult and embryonic tissues and are thought to have a broader spectrum of functions.
Tamagnone, Luca
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Structural Mechanisms of Semaphorin/Plexin Signaling

, 2016
Plexins are cell surface receptors that bind to their ligand semaphorins and transduce signals for regulating processes including neuronal development, angiogenesis and immune response.
Wang, Yuxiao
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Differential Requirement for Plexin-A3 and -A4 in Mediating Responses of Sensory and Sympathetic Neurons to Distinct Class 3 Semaphorins

, 2005
SummaryThe class 3 Semaphorins Sema3A and Sema3F are potent axonal repellents that cause repulsion by binding Neuropilin-1 and Neuropilin-2, respectively.
Yaron, Avraham, Huang, Pei-Hsin, Pei-Hsin Huang, Cheng, Hwai-Jong, Tessier-Lavigne, Marc, Hwai-Jong Cheng, Avraham Yaron, Marc Tessier-Lavigne   +7 more
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Impact of semaphorin expression on prognostic characteristics in breast cancer

Breast Cancer: Targets and Therapy, 2018
Ramesh Butti, Totakura VS Kumar, Ramakrishna Nimma, Gopal C Kundu Laboratory of Tumor Biology, Angiogenesis and Nanomedicine Research, National Centre for Cell Science, Savitribai Phule Pune University, Pune, India Abstract: Breast cancer is one of the ...
Butti R, Kumar TVS, Nimma R, Kundu GC
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