Results 21 to 30 of about 2,043 (169)
Plexin B3 promotes neurite outgrowth, interacts homophilically, and interacts with Rin
BMC Neuroscience, 2005 Background Plexins, known to date as receptors of semaphorins, are implicated in semaphorin-mediated axon repulsion and growth cone collapse. However, subtype-specific functions of the majority of the nine members of the mammalian plexin family are ...
Rosenberger Georg +4 more
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Crystal structure of the Sema-PSI extracellular domain of human RON receptor tyrosine kinase. [PDF]
PLoS ONE, 2012 Human RON (Recepteur d'Origine Nantais) receptor tyrosine kinase is a cell surface receptor for Macrophage Stimulating Protein (MSP). RON mediates signal transduction pathways that regulate cell adhesion, invasion, motility and apoptosis processes ...
Kinlin L Chao +3 more
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Structural mechanisms of plexin signaling [PDF]
Progress in Biophysics and Molecular Biology, 2015 Signaling through plexin, the major cell surface receptor for semaphorin, plays critical roles in regulating processes such as neuronal axon guidance, angiogenesis and immune response. Plexin is normally kept inactive in the absence of semaphorin. Upon binding of semaphorin to the extracellular region, plexin is activated and transduces signal to the ...
Heath G, Pascoe +2 more
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Semaphorins and Plexins in Kidney Disease [PDF]
Nephron, 2016 Semaphorins are soluble or membrane-bound cues, which control multiple aspects of cell-cell communication, differentiation, morphology and function. Most of their effects are mediated by a family of transmembrane receptors called plexins. Semaphorins and plexins have emerged as central regulators of diverse physiological and pathophysiological ...
Xia , J., Worzfeld, T.
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MICAL redox enzymes and actin remodeling: New links to classical tumorigenic and cancer pathways
Molecular & Cellular Oncology, 2018 MICAL Redox enzymes have recently emerged as direct regulators of cell shape and motility – working through specific reversible post-translational oxidation of actin to disassemble and remodel the cytoskeleton.
Jimok Yoon, Jonathan R. Terman
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Identification and characterization of a novel mouse plexin, plexin-A4
Mechanisms of Development, 2003 Plexins belonging to the plexin-A subfamily form complexes with neuropilins and propagate signals of class 3 semaphorins into neurons, even though they do not directly bind the semaphorins. In this study, we identified a new member of the plexin-A subfamily in the mice, plexin-A4, and showed that it was expressed in the developing nervous system with a
Suto, Fumikazu +4 more
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A perspective on the role of class III semaphorin signaling in central nervous system trauma
Frontiers in Cellular Neuroscience, 2014 Traumatic injury of the central nervous system (CNS) has severe impact on the patients’ quality of life and initiates many molecular and cellular changes at the site of insult.
Vasil eMecollari +3 more
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Plexin-B1 and Plexin-B2 play non-redundant roles in GABAergic synapse formation
Molecular and Cellular Neuroscience, 2023 Abstract Synapse formation in the mammalian brain is a complex and dynamic process requiring coordinated function of dozens of molecular families such as cell adhesion molecules (CAMs) and ligand-receptor pairs (Ephs/Ephrins, Neuroligins/Neurexins, Semaphorins/Plexins).
Susannah S. Adel +6 more
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Nature Communications, 2020 Plexins are the receptors for the guidance molecules semaphorins and regulate immunity and the development of the nervous and cardiovascular systems. Here authors present a structure of full-length human PlexinC1 in complex with its ligand A39R, which ...
Yi-Chun Kuo +6 more
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eLife, 2013 Plexins are cell surface receptors that bind semaphorins and transduce signals for regulating neuronal axon guidance and other processes. Plexin signaling depends on their cytoplasmic GTPase activating protein (GAP) domain, which specifically inactivates
Yuxiao Wang +4 more
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