Results 21 to 30 of about 2,365 (188)
A dual binding mode for RhoGTPases in plexin signalling.
PLoS Biology, 2011 Plexins are cell surface receptors for the semaphorin family of cell guidance cues. The cytoplasmic region comprises a Ras GTPase-activating protein (GAP) domain and a RhoGTPase binding domain.
Christian H Bell +3 more
doaj +5 more sources
Nanobody inhibitors of Plexin-B1 identify allostery in plexin-semaphorin interactions and signaling. [PDF]
J Biol Chem, 2023 Plexin-B1 is a receptor for the cell surface semaphorin, Sema4D. This signaling system has been implicated in a variety of human diseases, including cancer, multiple sclerosis and osteoporosis. While inhibitors of the Plexin-B1:Sema4D interaction have been previously reported, understanding their mechanism has been hindered by an incomplete structural ...
Cowan R +9 more
europepmc +3 more sources
The IκB kinase complex is required for plexin-B-mediated activation of RhoA. [PDF]
PLoS ONE, 2014 Plexins are widely expressed transmembrane proteins that mediate the cellular effects of semaphorins. The molecular mechanisms of plexin-mediated signal transduction are still poorly understood.
Matthias Zielonka +3 more
doaj +1 more source
Semaphorins in Angiogenesis and Autoimmune Diseases: Therapeutic Targets?
Frontiers in Immunology, 2020 The axonal guidance molecules, semaphorins, have been described to function both physiologically and pathologically outside of the nervous system. In this review, we focus on the vertebrate semaphorins found in classes 3 through 7 and their roles in ...
Vijaya Iragavarapu-Charyulu +2 more
doaj +1 more source
Evolution and Diversity of Semaphorins and Plexins in Choanoflagellates [PDF]
Genome Biology and Evolution, 2021 Abstract Semaphorins and plexins are cell surface ligand/receptor proteins that affect cytoskeletal dynamics in metazoan cells. Interestingly, they are also present in Choanoflagellata, a class of unicellular heterotrophic flagellates that forms the phylogenetic sister group to Metazoa. Several members of choanoflagellates are capable of
Chrystian Junqueira Alves +7 more
openaire +2 more sources
p190 Rho-GTPase activating protein associates with plexins and it is required for semaphorin signalling [PDF]
, 2005 Plexins are transmembrane receptors for semaphorins, guiding cell migration and axon extension. Plexin activation leads to the disassembly of integrin-based focal adhesive structures and to actin cytoskeleton remodelling and inhibition of cell migration;
Davide Barberis +16 more
core +2 more sources
Structural mechanisms of plexin signaling [PDF]
Progress in Biophysics and Molecular Biology, 2015 Signaling through plexin, the major cell surface receptor for semaphorin, plays critical roles in regulating processes such as neuronal axon guidance, angiogenesis and immune response. Plexin is normally kept inactive in the absence of semaphorin. Upon binding of semaphorin to the extracellular region, plexin is activated and transduces signal to the ...
Heath G, Pascoe +2 more
openaire +2 more sources