Results 1 to 10 of about 5,876 (133)

Konjac Ceramide Induces Semaphorin 3A Expression via the MAPK/AP-1 Signaling Axis and RORα in Normal Human Epidermal Keratinocytes [PDF]

Biomolecules
Epidermal hyperinnervation is a major cause of intractable itch in barrier dysfunction conditions such as atopic dermatitis. Keratinocyte-derived semaphorin 3A (Sema3A) suppresses epidermal hyperinnervation, but its expression is markedly reduced in ...
Mirei Fujita, Yayoi Kamata, Nanami Tanemoto, Nobuaki Takahashi, Mitsutoshi Tominaga, Kenji Takamori   +5 more
doaj   +2 more sources

Identification and Functional Characterization of a Novel SEMA3A Exon Deletion Variant in Kallmann Syndrome [PDF]

Molecular Genetics & Genomic Medicine
Background Kallmann syndrome (KS) is a genetic disorder characterized by impaired reproductive system and olfactory development. This study aimed to identify a novel variant of SEMA3A in a KS patient and explore its potential pathogenic mechanism ...
Shaolian Zang, Shasha Zhou, Qingxu Liu, Xiaoqin Yin, Pin Li   +4 more
doaj   +2 more sources

Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2-skewed immune polarization. [PDF]

J Pathol
Abstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Takada M, Sashikawa-Kimura M, Ohno Y, Hossain MR, Xie X, Iwabuchi K, Komine M, Ohtsuki M, Imokawa G.   +8 more
europepmc   +2 more sources

Plasma Semaphorin 3A as a Potential Biomarker for Cognitive Impairment in Cerebral Small Vessel Disease [PDF]

International Journal of General Medicine
Haoran Ma, Hong Li, Xinyi Fu, Xuening Li, Chenchen Wei, Aijun Ma Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of ChinaCorrespondence: Aijun Ma; Chenchen Wei, Email drmaj@qdu.edu.cn; weichenchen2020 ...
Ma H, Li H, Fu X, Li X, Wei C, Ma A
doaj   +2 more sources

P. Gingivalis LPS Drives Osteoclastogenesis and Impairs Osteoblast Differentiation by Suppressing Sema3A/Nrp1 Via TLR-4 [PDF]

International Dental Journal
Objectives: This study demonstrates that the Sema3A/Nrp1 pathway confers protection against Porphyromonas gingivalis LPS (P-LPS)-induced osteolysis and identifies key molecular mechanisms involved.
Jingyi Feng, Dongjie Fu, Sandeth Phan, Xiaoli Hu, Quan Xing   +4 more
doaj   +2 more sources

Sema3A inactivates the ERK/JNK signalling pathways to alleviate inflammation and oxidative stress in lipopolysaccharide-stimulated rat endothelial cells and lung tissues

Autoimmunity, 2023
Semaphorin 3A (Sema3A) is a secretory member of the semaphorin family of immune response regulators. This research focuses on its effects on inflammation and oxidative stress in acute respiratory distress syndrome (ARDS).
Qianwen Qiu, Xiufeng Yu, Qingli Chen, Xuwei He   +3 more
doaj   +1 more source

Semaphorin 3A regulates alveolar bone remodeling on orthodontic tooth movement

Scientific Reports, 2022
Semaphorin 3A (Sema3A) promotes osteoblast differentiation and inhibits osteoclast differentiation. In the present study, we observed the regulation of alveolar bone remodeling by Sema3A during orthodontic tooth movement (OTM).
Hirokazu Kamei, Takenobu Ishii, Yasushi Nishii   +2 more
doaj   +1 more source

Semaphorin 3A contributes to distal pulmonary epithelial cell differentiation and lung morphogenesis. [PDF]

PLoS ONE, 2011
Semaphorin 3A (Sema3A) is a neural guidance cue that also mediates cell migration, proliferation and apoptosis, and inhibits branching morphogenesis.
Patrice M Becker, Tracy S Tran, Michael J Delannoy, Chaoxia He, John M Shannon, Sharon McGrath-Morrow   +5 more
doaj   +1 more source

Influences of Semaphorin 3A Expression on Clinicopathological Features, Human Papillomavirus Status, and Prognosis in Oropharyngeal Carcinoma

Microorganisms, 2020
Human papillomavirus (HPV) infection is now identified as a major etiologic factor for oropharyngeal cancer (OPC), and HPV positivity is well established better prognostic marker in OPC.
Hai Thanh Pham, Satoru Kondo, Kazuhira Endo, Naohiro Wakisaka, Yoshitaka Aoki, Yosuke Nakanishi, Kina Kase, Harue Mizokami, Makoto Kano, Takayoshi Ueno, Miyako Hatano, Makiko Moriyama-Kita, Hisashi Sugimoto, Tomokazu Yoshizaki   +13 more
doaj   +1 more source

A nonsynonymous polymorphism in semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation. [PDF]

PLoS Genetics, 2013
Unexplained cardiac arrest (UCA) with documented ventricular fibrillation (VF) is a major cause of sudden cardiac death. Abnormal sympathetic innervations have been shown to be a trigger of ventricular fibrillation. Further, adequate expression of SEMA3A
Yukiko Nakano, Kazuaki Chayama, Hidenori Ochi, Masaaki Toshishige, Yasufumi Hayashida, Daiki Miki, C Nelson Hayes, Hidekazu Suzuki, Takehito Tokuyama, Noboru Oda, Kazuyoshi Suenari, Yuko Uchimura-Makita, Kenta Kajihara, Akinori Sairaku, Chikaaki Motoda, Mai Fujiwara, Yoshikazu Watanabe, Yukihiko Yoshida, Kimie Ohkubo, Ichiro Watanabe, Akihiko Nogami, Kanae Hasegawa, Hiroshi Watanabe, Naoto Endo, Takeshi Aiba, Wataru Shimizu, Seiko Ohno, Minoru Horie, Koji Arihiro, Satoshi Tashiro, Naomasa Makita, Yasuki Kihara   +31 more
doaj   +1 more source