Expression of semaphorin 3A (SEMA3A) in breast cancer subtypes
Scientific Reports, 2023 Breast cancer is a major health concern, and its accurate diagnosis and management depend on identifying its histological type and biological subtype. Semaphorin-3A (SEMA3A) is a membrane protein with diverse roles in cellular processes, including cancer
Natalia Andryszak +6 more
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Konjac Ceramide Induces Semaphorin 3A Expression via the MAPK/AP-1 Signaling Axis and RORα in Normal Human Epidermal Keratinocytes [PDF]
BiomoleculesEpidermal hyperinnervation is a major cause of intractable itch in barrier dysfunction conditions such as atopic dermatitis. Keratinocyte-derived semaphorin 3A (Sema3A) suppresses epidermal hyperinnervation, but its expression is markedly reduced in ...
Mirei Fujita +5 more
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Identification and Functional Characterization of a Novel SEMA3A Exon Deletion Variant in Kallmann Syndrome [PDF]
Molecular Genetics & Genomic MedicineBackground Kallmann syndrome (KS) is a genetic disorder characterized by impaired reproductive system and olfactory development. This study aimed to identify a novel variant of SEMA3A in a KS patient and explore its potential pathogenic mechanism ...
Shaolian Zang +4 more
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Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A [PDF]
Scientific Reports, 2018 Semaphorin 3A (Sema3A), a secreted member of the Semaphorin family, increases osteoblast differentiation, stimulates bone formation and enhances fracture healing.
Daniëlle de Ridder +6 more
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Plasma Semaphorin 3A as a Potential Biomarker for Cognitive Impairment in Cerebral Small Vessel Disease [PDF]
International Journal of General MedicineHaoran Ma, Hong Li, Xinyi Fu, Xuening Li, Chenchen Wei, Aijun Ma Department of Neurology, The Affiliated Hospital of Qingdao University, Qingdao, People’s Republic of ChinaCorrespondence: Aijun Ma; Chenchen Wei, Email drmaj@qdu.edu.cn; weichenchen2020 ...
Ma H, Li H, Fu X, Li X, Wei C, Ma A
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P. Gingivalis LPS Drives Osteoclastogenesis and Impairs Osteoblast Differentiation by Suppressing Sema3A/Nrp1 Via TLR-4 [PDF]
International Dental JournalObjectives: This study demonstrates that the Sema3A/Nrp1 pathway confers protection against Porphyromonas gingivalis LPS (P-LPS)-induced osteolysis and identifies key molecular mechanisms involved.
Jingyi Feng +4 more
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Exploring the Prognostic Role of Neurofilaments and SEMA3A in Multiple Sclerosis Progression. [PDF]
Int J Mol SciThe transition from relapsing–remitting multiple sclerosis (RRMS) to secondary progressive multiple sclerosis (SPMS) is characterized by an increasing neurodegenerative component. Identifying biomarkers that distinguish these disease stages is crucial for early diagnosis and treatment optimization.
Pavelek Z +7 more
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Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex [PDF]
Nature Communications, 2021 AbstractSecreted class 3 semaphorins (Sema3s) form tripartite complexes with the plexin receptor and neuropilin coreceptor, which are both transmembrane proteins that together mediate semaphorin signal for neuronal axon guidance and other processes.
Defen Lu +4 more
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Autoimmunity, 2023 Semaphorin 3A (Sema3A) is a secretory member of the semaphorin family of immune response regulators. This research focuses on its effects on inflammation and oxidative stress in acute respiratory distress syndrome (ARDS).
Qianwen Qiu +3 more
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Semaphorin 3A regulates alveolar bone remodeling on orthodontic tooth movement
Scientific Reports, 2022 Semaphorin 3A (Sema3A) promotes osteoblast differentiation and inhibits osteoclast differentiation. In the present study, we observed the regulation of alveolar bone remodeling by Sema3A during orthodontic tooth movement (OTM).
Hirokazu Kamei +2 more
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