Results 31 to 40 of about 5,937 (178)

Semaphorin3A Exacerbates Cardiac Microvascular Rarefaction in Pressure Overload‐Induced Heart Disease

Advanced Science, 2023
Microvascular endothelial cells (MiVECs) impair angiogenic potential, leading to microvascular rarefaction, which is a characteristic feature of chronic pressure overload‐induced cardiac dysfunction.
Chaofu Li, Yongchao Zhao, Fuhai Li, Zimu Wang, Zhimei Qiu, Yukun Yang, Weidong Xiong, Rui Wang, Han Chen, Fei Xu, Tongtong Zang, Zhiqiang Pei, Yan Wang, Bei Shi, Li Shen, Junbo Ge   +15 more
doaj   +1 more source

Discovery of a Novel Variant of SEMA3A in a Chinese Patient with Isolated Hypogonadotropic Hypogonadism

International Journal of Endocrinology, 2021
Semaphorin (SEMA) has an important role in nerve development, organ formation, immune response, angiogenesis, and tumor growth. SEMA can regulate the growth and branching of axons, the morphology of dendrites, and the migration of neurons.
Wenting Dai, Jia-Da Li, Xinying Wang, Wang Zeng, Fang Jiang, Ruizhi Zheng   +5 more
doaj   +1 more source

Osseointegration of Titanium Implants in a Botox-Induced Muscle Paralysis Rat Model Is Sensitive to Surface Topography and Semaphorin 3A Treatment

Biomimetics, 2023
Reduced skeletal loading associated with many conditions, such as neuromuscular injuries, can lead to bone fragility and may threaten the success of implant therapy.
Jingyao Deng, D. Joshua Cohen, Michael B. Berger, Eleanor L. Sabalewski, Michael J. McClure, Barbara D. Boyan, Zvi Schwartz   +6 more
doaj   +1 more source

PTEN couples Sema3A signalling to growth cone collapse [PDF]

Journal of Cell Science, 2006
Distinct changes in glycogen synthase kinase-3 (GSK-3) signalling can regulate neuronal morphogenesis including the determination and maintenance of axonal identity, and are required for neurotrophin-mediated axon elongation. In addition, we have previously shown a dependency on GSK-3 activation in the semaphorin 3A (Sema3A)-mediated growth-cone ...
Chadborn, N H, Ahmed, A I, Holt, M R, Prinjha, R, Dunn, G A, Jones, G E, Eickholt, B J   +6 more
openaire   +3 more sources

Konjac ceramide (kCer) regulates keratinocyte migration by Sema3A-like repulsion mechanism

Biochemistry and Biophysics Reports, 2019
Previously, we proposed the following mechanism for konjac ceramide (kCer)-mediated neurite outgrowth inhibition: kCer binds to Nrp as a Sema3A agonist, resulting in Nrp1/PlexA complex formation and activation of the Sema3A signaling pathway to induce ...
Seigo Usuki, Noriko Tamura, Tomohiro Tamura, Shigeki Higashiyama, Kunikazu Tanji, Susumu Mitsutake, Asuka Inoue, Junken Aoki, Katsuyuki Mukai, Yasuyuki Igarashi   +9 more
doaj   +1 more source

Neurovascular coupling in bone regeneration: Mechanisms, advanced biomaterials and challenges

BMEMat, EarlyView.
This figure illustrates various material strategies for neurovascularized bone regeneration, including electroactive scaffolds, ion‐loaded materials, drug delivery systems, surface modifications, cells/cell products, growth factors, and peptides. These approaches aim to synergistically promote the regeneration of neural, vascular, and bone tissues ...
Yixin Ma, Nan Jiang, Liyuan Chen, He Zhang, Xinjia Cai, Karan Gulati, Danqing He, Zhigang Cai, Yan Liu   +8 more
wiley   +1 more source

Plasma and Synovial Fluid VEGF‐A and Neuropilin‐1 in Knee Osteoarthritis: Associations With Radiographic Severity, Pain Sensitization‐Related Features, and Disease Burden

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study aimed to investigate associations of plasma and synovial fluid vascular endothelial growth factor A (VEGF‐A) and neuropilin‐1 (NRP1) levels with radiographic severity, pain sensitization‐related features, and disease burden in knee osteoarthritis (KOA). Plasma VEGF‐A and NRP1 were measured by sandwich ELISA in 120 patients with KOA (
Cheng‐Ju Tan
wiley   +1 more source

Sema3A Reduces Sprouting of Adult Rod Photoreceptors In Vitro

Investigative Opthalmology & Visual Science, 2017
Rod photoreceptor terminals respond to retinal injury with retraction and sprouting. Since the guidance cue Semaphorin3A (Sema3A) is observed in the retina after injury, we asked whether Sema3A contributes to structural plasticity in rod photoreceptors.We used Western blots and alkaline phosphatase (AP)-tagged neuropilin-1 (NPN-1) to detect the ...
Kung, Frank, Wang, Weiwei, Tran, Tracy S., Townes-Anderson, Ellen   +3 more
openaire   +2 more sources

Monogenic and syndromic obesity in children: Clinical recognition, genetics, and precision management

Pediatric Investigation, EarlyView.
Monogenic and syndromic obesity in children often arises from defects in the leptin–melanocortin pathway. Understanding these rare genetic causes not only clarifies mechanisms of appetite regulation but also enables precision therapies, offering hope beyond lifestyle interventions.
Hadel Khalil, Eugene Feigin, Hussein Zaitoon   +2 more
wiley   +1 more source

Sema3a Promotes Type H Vessel Formation Via Nrp1pdgf-Bb

International Dental Journal
Aim or purpose: To investigate the effect of Semaphorin3A (Sema3A) on type H vessel formation and alveolar bone resorption within periodontitis. Materials and methods: Conditioned media derived from preosteoclasts pretreated with the Sema3A, Sema3A ...
Maerwa Mulatihaji, Yi-Fan Zhang, Huan Zhou   +2 more
doaj   +1 more source