Results 31 to 40 of about 6,782 (204)

Semaphorin 3A—Glycosaminoglycans Interaction as Therapeutic Target for Axonal Regeneration

Pharmaceuticals, 2021
Semaphorin 3A (Sema3A) is a cell-secreted protein that participates in the axonal guidance pathways. Sema3A acts as a canonical repulsive axon guidance molecule, inhibiting CNS regenerative axonal growth and propagation.
Yolanda Pérez, Roman Bonet, Miriam Corredor, Cecilia Domingo, Alejandra Moure, Àngel Messeguer, Jordi Bujons, Ignacio Alfonso   +7 more
doaj   +1 more source

LncRNA TCF7 contributes to high glucose‐induced damage in human podocytes by up‐regulating SEMA3A via sponging miR‐16‐5p

Journal of Diabetes Investigation, 2023
Aims/Introduction Long non‐coding RNAs (lncRNAs) exert essential functions in the pathogenesis of diabetic nephropathy (DN). LncRNA T‐cell factor 7 (TCF7) and semaphorin‐3A (SEMA3A) have been found to be involved in the progression of diabetic ...
Zhenzhen Jiang, Lijie Qian, Ruifeng Yang, Yan Wu, Yongping Guo, Tingfang Chen   +5 more
doaj   +1 more source

The CRMP Family of Proteins and Their Role in Sema3A Signaling [PDF]

, 2007
The CRMP proteins were originally identified as mediators of Sema3A signaling and neuronal differentiation. Much has been learned about the mechanism by which CRMPs regulate cellular responses to Sema3A. In this review, the evidence for CRMP as a component of the Sema3A signaling cascade and the modulation of CRMP by plexin and phosphorylation are ...
Eric F, Schmidt, Stephen M, Strittmatter
openaire   +2 more sources

Neuropilin-1/GIPC1 signaling regulates α5β1 integrin traffic and function in endothelial cells [PDF]

, 2009
Neuropilin 1 (Nrp1) is a coreceptor for vascular endothelial growth factor A165 (VEGF-A165, VEGF-A164 in mice) and semaphorin 3A (SEMA3A). Nevertheless, <i>Nrp1</i> null embryos display vascular defects that differ from those of mice lacking ...
Caccavari, Francesca, Valdembri, D., Serini, G., Valdembri, Donatella, Caccavari, F., Caswell Patrick T, Anderson, K.I., Humphries, M.J., Patrick T Caswell, Anderson Kurt I, Anderson, Kurt I., Serini, Guido, Caccavari Francesca, Federico Bussolino, Elena Astanina, Valdembri Donatella, König, I., König, Ireen, Astanina, Elena, Schwarz, J.P., Francesca Caccavari, Jim C Norman, Humphries Martin J, Bussolino, F., Schwarz Juliane P, Guido Serini, Serini Guido, König Ireen, Schwarz, Juliane P., Bussolino, Federico, Kurt I Anderson, Humphries, Martin J., Caswell, Patrick T.; id_orcid, Norman, Jim C., Juliane P Schwarz, Astanina Elena, Astanina, E., Bussolino Federico, Norman, J.C., Donatella Valdembri, Caswell, P.T., Ireen König, Norman Jim C, Martin J Humphries   +43 more
core   +1 more source

Vinaxanthone inhibits Semaphorin3A induced axonal growth cone collapse in embryonic neurons but fails to block its growth promoting effects on adult neurons

Scientific Reports, 2021
Semaphorin3A is considered a classical repellent molecule for developing neurons and a potent inhibitor of regeneration after nervous system trauma. Vinaxanthone and other Sema3A inhibitors are currently being tested as possible therapeutics to promote ...
Evguenia Ivakhnitskaia, Matthew R. Chin, Dionicio Siegel, Victor H. Guaiquil   +3 more
doaj   +1 more source

Semaphorin 3A controls allergic and inflammatory responses in experimental allergic conjunctivitis

International Journal of Ophthalmology, 2015
AIM: To assess the efficacy of topical Semaphorin-3A (SEMA3A) in the treatment of allergic conjunctivitis. METHODS: Experimental allergic conjunctivitis (EAC) mice model induced by short ragweed pollen (SRW) in 4-week-old of BALB/c mice, mice were ...
Junmi Tanaka, Hideo Tanaka, Nobuhisa Mizuki, Eiichi Nomura, Hideo Tanaka, Naoko Nomura, Masayuki Yamane, Tomonobu Hida, Yoshio Goshima, Hiroshi Hatano, Hisashi Nakagawa   +10 more
doaj   +1 more source

Strukturelle und funktionelle Analyse des Signalmoleküls Sema3A

, 2005
Die Semaphorine repräsentieren die größte Proteinfamilie von Signalmolekülen, die an der axonalen Wegfindung im embryonalen Nervensystem beteiligt sind. Für eine spätere Kristallstrukturanalyse wurde die kollabierende Aktivität eines 65 kDa Fragmentes von Sema3A, welches die vollständige Semaphorin-Domäne enthält, bestimmt.
Hömme, C. (Claudia)
core   +2 more sources

Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress

Mediators of Inflammation, 2018
Background. Excessive mechanical stress causes inflammation and destruction of cartilage and is considered one of the cause of osteoarthritis (OA).
Chikako Sumi, Naoto Hirose, Makoto Yanoshita, Mami Takano, Sayuri Nishiyama, Yuki Okamoto, Yuki Asakawa, Kotaro Tanimoto   +7 more
doaj   +1 more source

R-type calcium channels are crucial for semaphorin 3A-induced DRG axon growth cone collapse. [PDF]

PLoS ONE, 2014
Semaphorin 3A (Sema3A) is a secreted protein involved in axon path-finding during nervous system development. Calcium signaling plays an important role during axonal growth in response to different guidance cues; however it remains unclear whether this ...
Rimantas Treinys, Andrius Kaselis, Emmanuel Jover, Dominique Bagnard, Saulius Šatkauskas   +4 more
doaj   +1 more source

Semaphorin 3A mediated brain tumor stem cell proliferation and invasion in EGFRviii mutant gliomas

BMC Cancer, 2020
Background Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, with a median survival of approximately 15 months. Semaphorin 3A (Sema3A), known for its axon guidance and antiangiogenic properties, has been implicated in GBM ...
Dominique M. O. Higgins, Maisel Caliva, Mark Schroeder, Brett Carlson, Pavan S. Upadhyayula, Brian D. Milligan, Samuel H. Cheshier, Irving L. Weissman, Jann N. Sarkaria, Fredric B. Meyer, John R. Henley   +10 more
doaj   +1 more source