Results 21 to 30 of about 5,937 (178)

Negative Regulation of Semaphorin-3A Expression in Peripheral Blood Mononuclear Cells Using MicroRNA-497-5p [PDF]

Iranian Journal of Medical Sciences, 2019
Background: Semaphorin-3A (Sema3A), as a secreted semaphorin, is an immune modulator molecule participating in the pathogenesis of autoimmune diseases. MicroRNAs (miRNAs) modulate the target-gene expression at the post-transcriptional level.
Shima Shapoori, Mazdak Ganjalikhani-Hakemi, Mahsa Rezaeepoor, Fereshteh Alsahebfosoul, Sharifeh Khosravi, Masoud Etemadifar, Marjan Mansourian   +6 more
doaj   +1 more source

Vinaxanthone inhibits Semaphorin3A induced axonal growth cone collapse in embryonic neurons but fails to block its growth promoting effects on adult neurons

Scientific Reports, 2021
Semaphorin3A is considered a classical repellent molecule for developing neurons and a potent inhibitor of regeneration after nervous system trauma. Vinaxanthone and other Sema3A inhibitors are currently being tested as possible therapeutics to promote ...
Evguenia Ivakhnitskaia, Matthew R. Chin, Dionicio Siegel, Victor H. Guaiquil   +3 more
doaj   +1 more source

Semaphorin 3A controls allergic and inflammatory responses in experimental allergic conjunctivitis

International Journal of Ophthalmology, 2015
AIM: To assess the efficacy of topical Semaphorin-3A (SEMA3A) in the treatment of allergic conjunctivitis. METHODS: Experimental allergic conjunctivitis (EAC) mice model induced by short ragweed pollen (SRW) in 4-week-old of BALB/c mice, mice were ...
Junmi Tanaka, Hideo Tanaka, Nobuhisa Mizuki, Eiichi Nomura, Hideo Tanaka, Naoko Nomura, Masayuki Yamane, Tomonobu Hida, Yoshio Goshima, Hiroshi Hatano, Hisashi Nakagawa   +10 more
doaj   +1 more source

The CRMP Family of Proteins and Their Role in Sema3A Signaling [PDF]

, 2007
The CRMP proteins were originally identified as mediators of Sema3A signaling and neuronal differentiation. Much has been learned about the mechanism by which CRMPs regulate cellular responses to Sema3A. In this review, the evidence for CRMP as a component of the Sema3A signaling cascade and the modulation of CRMP by plexin and phosphorylation are ...
Eric F, Schmidt, Stephen M, Strittmatter
openaire   +2 more sources

ERM proteins regulate growth cone responses to Sema3A [PDF]

Journal of Comparative Neurology, 2008
AbstractAxonal growth cones initiate and sustain directed growth in response to cues in their environment. A variety of events such as receptor internalization, kinase activation, and actin rearrangement can be stimulated by guidance cues and are essential for mediating targeted growth cone behavior.
C David, Mintz, Ioana, Carcea, Daniel G, McNickle, Tracey C, Dickson, Yongchao, Ge, Stephen R J, Salton, Deanna L, Benson   +6 more
openaire   +2 more sources

Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress

Mediators of Inflammation, 2018
Background. Excessive mechanical stress causes inflammation and destruction of cartilage and is considered one of the cause of osteoarthritis (OA).
Chikako Sumi, Naoto Hirose, Makoto Yanoshita, Mami Takano, Sayuri Nishiyama, Yuki Okamoto, Yuki Asakawa, Kotaro Tanimoto   +7 more
doaj   +1 more source

Semaphorin 3A mediated brain tumor stem cell proliferation and invasion in EGFRviii mutant gliomas

BMC Cancer, 2020
Background Glioblastoma multiforme (GBM) is the most common primary brain tumor in adults, with a median survival of approximately 15 months. Semaphorin 3A (Sema3A), known for its axon guidance and antiangiogenic properties, has been implicated in GBM ...
Dominique M. O. Higgins, Maisel Caliva, Mark Schroeder, Brett Carlson, Pavan S. Upadhyayula, Brian D. Milligan, Samuel H. Cheshier, Irving L. Weissman, Jann N. Sarkaria, Fredric B. Meyer, John R. Henley   +10 more
doaj   +1 more source

R-type calcium channels are crucial for semaphorin 3A-induced DRG axon growth cone collapse. [PDF]

PLoS ONE, 2014
Semaphorin 3A (Sema3A) is a secreted protein involved in axon path-finding during nervous system development. Calcium signaling plays an important role during axonal growth in response to different guidance cues; however it remains unclear whether this ...
Rimantas Treinys, Andrius Kaselis, Emmanuel Jover, Dominique Bagnard, Saulius Šatkauskas   +4 more
doaj   +1 more source

Semaphorin-3A as An Immune Modulator Is Suppressed by MicroRNA-145-5p

Cell Journal, 2018
Objective Semaphorin-3A (SEMA3A) and its receptors are found on some immune cells and act as suppressors of immune cells over-activation. Considering the role of SEMA3A and its down-regulation in some autoimmune diseases, as well as our bioinformatics ...
Mahsa Rezaeepoor, Mazdak Ganjalikhani-hakemi, Shima Shapoori, Nahid Eskandari, Mohammadreza Sharifi, Masoud Etemadifar, Marjan Mansourian   +6 more
doaj   +1 more source

Semaphorin3A induces nerve regeneration in the adult cornea-a switch from its repulsive role in development. [PDF]

PLoS ONE, 2018
The peripheral sensory nerves that innervate the cornea can be easily damaged by trauma, surgery, infection or diabetes. Several growth factors and axon guidance molecules, such as Semaphorin3A (Sema3A) are upregulated upon cornea injury.
Min Zhang, Qiang Zhou, Yuncin Luo, Tara Nguyen, Mark I Rosenblatt, Victor H Guaiquil   +5 more
doaj   +1 more source