Results 21 to 30 of about 6,782 (204)

ERM proteins regulate growth cone responses to Sema3A [PDF]

Journal of Comparative Neurology, 2008
AbstractAxonal growth cones initiate and sustain directed growth in response to cues in their environment. A variety of events such as receptor internalization, kinase activation, and actin rearrangement can be stimulated by guidance cues and are essential for mediating targeted growth cone behavior.
C David, Mintz, Ioana, Carcea, Daniel G, McNickle, Tracey C, Dickson, Yongchao, Ge, Stephen R J, Salton, Deanna L, Benson   +6 more
openaire   +3 more sources

Discovery of a Novel Variant of SEMA3A in a Chinese Patient with Isolated Hypogonadotropic Hypogonadism

International Journal of Endocrinology, 2021
Semaphorin (SEMA) has an important role in nerve development, organ formation, immune response, angiogenesis, and tumor growth. SEMA can regulate the growth and branching of axons, the morphology of dendrites, and the migration of neurons.
Wenting Dai, Jia-Da Li, Xinying Wang, Wang Zeng, Fang Jiang, Ruizhi Zheng   +5 more
doaj   +2 more sources

Konjac ceramide (kCer) regulates keratinocyte migration by Sema3A-like repulsion mechanism

Biochemistry and Biophysics Reports, 2019
Previously, we proposed the following mechanism for konjac ceramide (kCer)-mediated neurite outgrowth inhibition: kCer binds to Nrp as a Sema3A agonist, resulting in Nrp1/PlexA complex formation and activation of the Sema3A signaling pathway to induce ...
Seigo Usuki, Noriko Tamura, Tomohiro Tamura, Shigeki Higashiyama, Kunikazu Tanji, Susumu Mitsutake, Asuka Inoue, Junken Aoki, Katsuyuki Mukai, Yasuyuki Igarashi   +9 more
doaj   +2 more sources

Sema3A drastically suppresses tumor growth in oral cancer Xenograft model of mice

BMC Pharmacology and Toxicology, 2017
Background Multiple studies suggest anti-angiogenesis to be a promising and rational option in cancer treatment. Interestingly, the axonal sprouting inhibitor semaphorin 3A (Sema3A), a potent suppressor of tumor angiogenesis in various cancer models, is ...
Chao Huang, Yi Wang, Jian-Hua Huang, Weixian Liu   +3 more
doaj   +2 more sources

Biallelic SEMA3A defects cause a novel type of syndromic short stature

American Journal of Medical Genetics Part A, 2013
ABSTRACTChromosomal microarray testing is commonly used to identify disease causing de novo copy number variants in patients with developmental delay and multiple congenital anomalies. In such a patient we now observed an 150 kb deletion on chromosome 7q21.11 affecting the first exon of the axon guidance molecule gene SEMA3A (sema domain ...
Hofmann, Kristin, Zweier, Markus, Sticht, Heinrich, Zweier, Christiane, Wittmann, Wolfgang, Hoyer, Juliane, Uebe, Steffen, van Haeringen, Arie, Thiel, Christian T, Ekici, Arif B, Reis, André, Rauch, Anita   +11 more
openaire   +5 more sources

Adriamycin-induced podocyte injury via the Sema3A/TRPC5/Rac1 pathway

Frontiers in Medicine
Podocytopathies encompass kidney diseases where direct or indirect podocyte injury leads to proteinuria or nephrotic syndrome. Although Semaphorin3A (Sema3A) is expressed in podocytes and tubular cells in adult mammalian kidneys and has a common effect ...
Yan Liu, Yan Liu, Ri-Li Ge, Zhen-Zhen Shan, Yan-Jun Wang, Yan-Yan Yang, Xue Sun, Peng-Li Luo, Peng-Li Luo   +8 more
doaj   +3 more sources

Architecture of the Sema3A/PlexinA4/Neuropilin tripartite complex [PDF]

Nature Communications, 2021
AbstractSecreted class 3 semaphorins (Sema3s) form tripartite complexes with the plexin receptor and neuropilin coreceptor, which are both transmembrane proteins that together mediate semaphorin signal for neuronal axon guidance and other processes.
Defen Lu, Guijun Shang, Xiaojing He, Xiao-chen Bai, Xuewu Zhang   +4 more
openaire   +3 more sources

Gpr97 Exacerbates AKI by Mediating Sema3A Signaling [PDF]

Journal of the American Society of Nephrology, 2018
Background G protein-coupled receptors (GPCRs) participate in a variety of physiologic functions, and several GPCRs have critical physiologic and pathophysiologic roles in the regulation of renal function. We investigated the role of Gpr97, a newly identified member of the adhesion GPCR family, in AKI.
Wei, Fang, Ziying, Wang, Quanxin, Li, Xiaojie, Wang, Yan, Zhang, Yu, Sun, Wei, Tang, Chunhong, Ma, Jinpeng, Sun, Ningjun, Li, Fan, Yi   +10 more
openaire   +2 more sources

Overexpression of Semaphorin 3A is a Marker Associated with Poor Prognosis in Patients with Nasopharyngeal Carcinoma

Microorganisms, 2020
Semaphorins were discovered as guidance signals that mediate neural development. Recent studies suggest that semaphorin 3A (Sema3A), a member of the semaphorin family, is involved in the development of several cancers.
Tomoko Imoto, Satoru Kondo, Naohiro Wakisaka, Pham Tahnh Hai, Noriko Seishima, Makoto Kano, Takayoshi Ueno, Harue Mizokami, Yosuke Nakanishi, Miyako Hatano, Kazuhira Endo, Hisashi Sugimoto, Makiko Moriyama-Kita, Tomokazu Yoshizaki   +13 more
doaj   +1 more source

Negative Regulation of Semaphorin-3A Expression in Peripheral Blood Mononuclear Cells Using MicroRNA-497-5p [PDF]

Iranian Journal of Medical Sciences, 2019
Background: Semaphorin-3A (Sema3A), as a secreted semaphorin, is an immune modulator molecule participating in the pathogenesis of autoimmune diseases. MicroRNAs (miRNAs) modulate the target-gene expression at the post-transcriptional level.
Shima Shapoori, Mazdak Ganjalikhani-Hakemi, Mahsa Rezaeepoor, Fereshteh Alsahebfosoul, Sharifeh Khosravi, Masoud Etemadifar, Marjan Mansourian   +6 more
doaj   +1 more source