Results 11 to 20 of about 5,937 (178)
Acid ceramidase overactivity drives ceramide loss, leading to atopic dry skin and Th2-skewed immune polarization. [PDF]
J PatholAbstract Ceramide deficiency in the stratum corneum (SC) is a key etiological factor in atopic dermatitis (AD). To clarify the direct role of SC ceramide depletion in impairing SC barrier and water‐holding functions and in initiating AD‐like skin symptoms and disease‐specific molecular alterations, we generated Tg mice overexpressing a mutant form of ...
Takada M +8 more
europepmc +2 more sources
Semaphorin 3A contributes to distal pulmonary epithelial cell differentiation and lung morphogenesis. [PDF]
PLoS ONE, 2011 Semaphorin 3A (Sema3A) is a neural guidance cue that also mediates cell migration, proliferation and apoptosis, and inhibits branching morphogenesis.
Patrice M Becker +5 more
doaj +1 more source
Microorganisms, 2020 Human papillomavirus (HPV) infection is now identified as a major etiologic factor for oropharyngeal cancer (OPC), and HPV positivity is well established better prognostic marker in OPC.
Hai Thanh Pham +13 more
doaj +1 more source
Sema3a plays a role in the pathogenesis of CHARGE syndrome [PDF]
Human Molecular Genetics, 2018 CHARGE syndrome is an autosomal dominant malformation disorder caused by heterozygous loss of function mutations in the chromatin remodeler CHD7. Chd7 regulates the expression of Sema3a, which also contributes to the pathogenesis of Kallmann syndrome, a heterogeneous condition with the typical features hypogonadotropic hypogonadism and an impaired ...
Roser Ufartes +12 more
openaire +4 more sources
Genetic targeting of Purkinje fibres by Sema3a-CreERT2 [PDF]
Scientific Reports, 2018 AbstractThe maintenance of the heart rhythm and the conduction of excitatory signals require changing excitatory signals via electrical activity and coordination by communication between working and conductive cardiomyocytes. Understanding how the ventricular conduction system is established provides novel insights into the pathophysiological progress ...
Yan Li +8 more
openaire +2 more sources
Semaphorin 3A—Glycosaminoglycans Interaction as Therapeutic Target for Axonal Regeneration
Pharmaceuticals, 2021 Semaphorin 3A (Sema3A) is a cell-secreted protein that participates in the axonal guidance pathways. Sema3A acts as a canonical repulsive axon guidance molecule, inhibiting CNS regenerative axonal growth and propagation.
Yolanda Pérez +7 more
doaj +1 more source
A nonsynonymous polymorphism in semaphorin 3A as a risk factor for human unexplained cardiac arrest with documented ventricular fibrillation. [PDF]
PLoS Genetics, 2013 Unexplained cardiac arrest (UCA) with documented ventricular fibrillation (VF) is a major cause of sudden cardiac death. Abnormal sympathetic innervations have been shown to be a trigger of ventricular fibrillation. Further, adequate expression of SEMA3A
Yukiko Nakano +31 more
doaj +1 more source
Gpr97 Exacerbates AKI by Mediating Sema3A Signaling [PDF]
Journal of the American Society of Nephrology, 2018 Background G protein-coupled receptors (GPCRs) participate in a variety of physiologic functions, and several GPCRs have critical physiologic and pathophysiologic roles in the regulation of renal function. We investigated the role of Gpr97, a newly identified member of the adhesion GPCR family, in AKI.
Wei, Fang +10 more
openaire +2 more sources
Microorganisms, 2020 Semaphorins were discovered as guidance signals that mediate neural development. Recent studies suggest that semaphorin 3A (Sema3A), a member of the semaphorin family, is involved in the development of several cancers.
Tomoko Imoto +13 more
doaj +1 more source
Journal of Diabetes Investigation, 2023 Aims/Introduction Long non‐coding RNAs (lncRNAs) exert essential functions in the pathogenesis of diabetic nephropathy (DN). LncRNA T‐cell factor 7 (TCF7) and semaphorin‐3A (SEMA3A) have been found to be involved in the progression of diabetic ...
Zhenzhen Jiang +5 more
doaj +1 more source