Results 11 to 20 of about 6,782 (204)
Expression of semaphorin 3A (SEMA3A) in breast cancer subtypes
Scientific Reports, 2023 Breast cancer is a major health concern, and its accurate diagnosis and management depend on identifying its histological type and biological subtype. Semaphorin-3A (SEMA3A) is a membrane protein with diverse roles in cellular processes, including cancer
Natalia Andryszak +6 more
doaj +4 more sources
Bidirectional regulation of bone formation by exogenous and osteosarcoma-derived Sema3A [PDF]
Scientific Reports, 2018 Semaphorin 3A (Sema3A), a secreted member of the Semaphorin family, increases osteoblast differentiation, stimulates bone formation and enhances fracture healing.
Daniëlle de Ridder +6 more
doaj +7 more sources
Sema3a plays a role in the pathogenesis of CHARGE syndrome [PDF]
Human Molecular Genetics, 2018 CHARGE syndrome is an autosomal dominant malformation disorder caused by heterozygous loss of function mutations in the chromatin remodeler CHD7. Chd7 regulates the expression of Sema3a, which also contributes to the pathogenesis of Kallmann syndrome, a heterogeneous condition with the typical features hypogonadotropic hypogonadism and an impaired ...
Roser Ufartes +12 more
openaire +6 more sources
Science Signaling, 2010 Sema3A activates ROCK- and myosin-dependent contraction to promote dendritic cell entry into the lymphatics.
Elizabeth M. Adler
openaire +2 more sources
Genetic targeting of Purkinje fibres by Sema3a-CreERT2 [PDF]
Scientific Reports, 2018 AbstractThe maintenance of the heart rhythm and the conduction of excitatory signals require changing excitatory signals via electrical activity and coordination by communication between working and conductive cardiomyocytes. Understanding how the ventricular conduction system is established provides novel insights into the pathophysiological progress ...
Yan Li +8 more
openaire +4 more sources
Sema3A Reduces Sprouting of Adult Rod Photoreceptors In Vitro
Investigative Opthalmology & Visual Science, 2017 Rod photoreceptor terminals respond to retinal injury with retraction and sprouting. Since the guidance cue Semaphorin3A (Sema3A) is observed in the retina after injury, we asked whether Sema3A contributes to structural plasticity in rod photoreceptors.We used Western blots and alkaline phosphatase (AP)-tagged neuropilin-1 (NPN-1) to detect the ...
Kung, Frank +3 more
openaire +3 more sources
PTEN couples Sema3A signalling to growth cone collapse [PDF]
Journal of Cell Science, 2006 Distinct changes in glycogen synthase kinase-3 (GSK-3) signalling can regulate neuronal morphogenesis including the determination and maintenance of axonal identity, and are required for neurotrophin-mediated axon elongation. In addition, we have previously shown a dependency on GSK-3 activation in the semaphorin 3A (Sema3A)-mediated growth-cone ...
Chadborn, N H +6 more
openaire +5 more sources
SEMA3A Signaling Controls Layer-Specific Interneuron Branching in the Cerebellum [PDF]
Current Biology, 2013 GABAergic interneurons regulate the balance and dynamics of neural circuits, in part, by elaborating their strategically placed axon branches that innervate specific cellular and subcellular targets. However, the molecular mechanisms that regulate target-directed GABAergic axon branching are not well understood.Here we show that the secreted axon ...
Cioni, Jean-Michel +8 more
openaire +3 more sources
SEMA3A partially reverses VEGF effects through binding to neuropilin-1 [PDF]
Stem Cell Research, 2017 Cross-talk between hematopoietic stem cells (HSCs) and bone marrow stromal cells (BMSCs) is essential for HSCs regulation and leukemogenesis. Studying bone marrow of myelodysplasia patients, a pre-leukemic condition, we found mRNA overexpression of ...
Bruna Palodetto +10 more
doaj +2 more sources
Sema3A accelerates bone formation during distraction osteogenesis in mice
Connective Tissue Research, 2021 Distraction osteogenesis (DO) is a bone regeneration technique used to treat maxillofacial disorders, fracture nonunion, and large bone defects. It is well known for its amazing regenerative potential, but an extended consolidation period limits its clinical use.
Nian, Zhang +3 more
openaire +3 more sources