Results 51 to 60 of about 6,782 (204)
Sema3a Promotes Type H Vessel Formation Via Nrp1pdgf-Bb
International Dental JournalAim or purpose: To investigate the effect of Semaphorin3A (Sema3A) on type H vessel formation and alveolar bone resorption within periodontitis. Materials and methods: Conditioned media derived from preosteoclasts pretreated with the Sema3A, Sema3A ...
Maerwa Mulatihaji +2 more
doaj +1 more source
Caenorhabditis elegans as an in vivo model system for human inherited primary arrhythmia syndromes
The Journal of Physiology, EarlyView.Abstract figure legend Most genes involved in inherited primary arrhythmia syndromes (IPAS) are conserved in Caenorhabditis elegans, where genetic manipulation enables functional characterization of variants, identification of regulatory proteins, and in vivo drug testing.
Antoine Delinière +6 more
wiley +1 more source
Axon guidance cue SEMA3A promotes the aggressive phenotype of basal-like PDAC [PDF]
Objective: The dysregulation of the axon guidance pathway is common in pancreatic ductal adenocarcinoma (PDAC), yet our understanding of its biological relevance is limited.
Bronte, Vincenzo +27 more
core +2 more sources
Exploring the Prognostic Role of Neurofilaments and SEMA3A in Multiple Sclerosis Progression. [PDF]
Int J Mol SciThe transition from relapsing–remitting multiple sclerosis (RRMS) to secondary progressive multiple sclerosis (SPMS) is characterized by an increasing neurodegenerative component. Identifying biomarkers that distinguish these disease stages is crucial for early diagnosis and treatment optimization.
Pavelek Z +7 more
europepmc +3 more sources
, 2015 A representative biopsy from an active CD patient in which sema3A is intensely stained (+3) in the macrophages of the lamina propria (similarly in all studied groups). Black arrows denote positively stained macrophages.
Zahava Vadasz (740010) +6 more
core +1 more source
The Journal of Dermatology, Volume 53, Issue 6, Page 867-879, June 2026.ABSTRACT Atopic dermatitis (AD) is a chronic inflammatory dermatitis underpinned by Type 2 inflammation driven by cytokines such as IL‐4 and IL‐13. It is characterized by skin barrier dysfunction, Th2 immune deviation, and pruritus. While biologics and oral Janus kinase (JAK) inhibitors demonstrate high therapeutic efficacy by targeting cytokines that ...
Gaku Tsuji +7 more
wiley +1 more source
Advanced Science, Volume 13, Issue 25, 4 May 2026.Resident myonuclei are the molecular “control centers” for large multinuclear muscle fibers. It is presumed that, with aging, these control centers become compromised and contribute to delayed or blunted muscle adaptive potential. This study is a detailed roadmap that exposes how young versus aged myonuclei respond to a hypertrophic loading stimulus ...
Pieter J. Koopmans +8 more
wiley +1 more source
Frontiers in Immunology, 2019 Semaphorin 3A (sema3A) belongs to the sub-family of the immune semaphorins that function as regulators of immune-mediated inflammation. Sema3A is a membrane associated molecule on T regulatory cells and on B regulatory cells. Being transiently ligated to
Sabag D. Adi +8 more
doaj +1 more source
Clinical and Translational Medicine, Volume 16, Issue 5, May 2026.• Excitatory neurons and astrocytes show marked alterations in the single‐cell spatial transcriptomic atlas of epileptogenic cortex from patients with focal cortical dysplasia type I (FCDI). • The CBLN2high excitatory neuron subtype may be associated with neuronal hyperexcitability and cortical development in FCDI.
Yaqian Zhang +9 more
wiley +1 more source
sAPPα modulates the biological activity of Sema3A.
, 2013 Growth cone morphology was examined in control chick DRG explants (A,E) and in explants challenged for 30 minutes with 0.8 nM Sema3A (B,F), Sema3A+75 nM sAPPα695 (C,G) or Sema3A+sAPPα695+75 nM each of peptides ARSHPAM and LTASLLI (D,H).
Matthias Gralle (347035) +8 more
core +1 more source