Results 61 to 70 of about 5,937 (178)

Recent Advances in Natural Polymers‐based Hydrogels for Periodontal Regeneration

Macromolecular Bioscience, Volume 26, Issue 5, May 2026.
Natural polymer‐based hydrogels are emerging as promising biomimetic platforms for periodontal regeneration. This review highlights advances in alginate, collagen, and chitosan hydrogels engineered to modulate inflammation, deliver bioactive agents, and support tissue repair.
João de Freitas Gomes Neto, Tainara de Paula de Lima Lima, Luiza Meurer Brand, Caio Fernando Cardoso Souza, Marcelo Lazzaron Lamers, Pedro L. Granja, Luiz Antonio Pessan, Eduardo Henrique Backes   +7 more
wiley   +1 more source

Diminished and Altered Cellular Senescence Response in Delayed Wound Healing of Aging

Aging Cell, Volume 25, Issue 5, May 2026.
Acute wound healing in young skin is supported by a transient population of senescent fibroblasts with proreparative, ECM‐remodeling functions. Aging disrupts both the induction and functional identity of these cells, contributing to delayed wound closure and impaired tissue repair.
Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Qiaoling Wang, Grace Haeun Shin, Jannat Dhillon, Daniel Sam Roh   +5 more
wiley   +1 more source

A Preliminary Study of the Effect of Semaphorin 3A and Acitretin on the Proliferation, Migration, and Apoptosis of HaCaT Cells

Indian Journal of Dermatology, 2019
Background: Vascular endothelial growth factor (VEGF) is significantly elevated in psoriatic patients and is associated with the severity of the psoriasis.
Wei Ding, Yi Cao, Fengling Xing, Maocan Tao, Hongyang Fu, Hongbin Luo, Xiaohong Yang   +6 more
doaj   +1 more source

Region‐to‐Region Unidirectional Connection In Vitro Brain Model for Studying Directional Propagation of Neuropathologies

Advanced Functional Materials, Volume 36, Issue 33, 23 April 2026.
A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang, Hui‐Wen Liu, Hyogeun Shin, Hyun Wook Kang, Minjin Kang, Jongbaeg Kim, Il‐Joo Cho, Nakwon Choi, Seok Chung, Hong Nam Kim   +9 more
wiley   +1 more source

Sema3A regulates metastasis through epithelial-mesenchymal transition/matrix metalloproteinase-2 in epithelial ovarian cancer

Zhongguo aizheng zazhi, 2020
Background and purpose: Semaphorin 3A (Sema3A) is initially considered to play an important role in axonal orientation. Recently, Sema3A has also been considered as a candidate tumor suppressor involved in the tumorigenesis. The purpose of this study was
王晓琴, 傅鑫蕾, 马如越, 杨丽娜, 陈亚萍, 张丽文   +5 more
doaj  

Soluble Sema4D From γδ T Cells Exerts Osteoblast Inhibition via Plexin‐B/mTOR Signalling Contributing to Pathogenesis of Bisphosphonate‐Related Osteonecrosis of the Jaws

Cell Proliferation, Volume 59, Issue 4, April 2026.
Schematic summarizing the pathway of sSema4D from γδ T cells inhibiting osteoblast differentiation in BRONJ. ABSTRACT Bisphosphonate‐related osteonecrosis of the jaw (BRONJ) is a severe complication in patients undergoing long‐term bisphosphonate therapy, while our knowledge on the pathogenesis of BRONJ is far from sufficient.
Lingling Ou, Shijia Qiao, Zhuoyi Liao, Xiner Tan, Hui Huang, Zhiyan Zhou, Ruhui Luo, Weijun Zeng, Yan Yang, Zhongxuan Zhang, Jingchen Chen, Shengli Wang, Yiqin Jiang, Jianlei Hao, Yuqin Shen, Longquan Shao   +15 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, Volume 20, Issue 3, Page 753-778, March 2026.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Characterization of Konjac Ceramide (kCer) Binding to Sema3A Receptor Nrp1

Journal of Oleo Science, 2018
Konjac ceramide (kCer) can be prepared by a chemoenzymatic method as previously published (Usuki, S.; Tamura, N.; Sakai, S.; Tamura, T.; Mukai, K.; Igarashi, Y. Biochem. Biophys. Rep. 5, 160-167 (2016)). Thus prepared kCer showed an activation effect on Sema3A signaling pathway to induce phosphorylation of CRMP2 and microtubule depolymerizaion ...
Usuki, Seigo, Tamura, Noriko, Tamura, Tomohiro, Mukai, Katsuyuki, Igarashi, Yasuyuki   +4 more
openaire   +3 more sources

Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells

Nature Communications
Semaphorin-3A (SEMA3A) functions as a chemorepulsive signal during development and can affect T cells by altering their filamentous actin (F-actin) cytoskeleton.
Mike B. Barnkob, Yale S. Michaels, Violaine André, Philip S. Macklin, Uzi Gileadi, Salvatore Valvo, Margarida Rei, Corinna Kulicke, Ji-Li Chen, Vitul Jain, Victoria K. Woodcock, Huw Colin-York, Andreas V. Hadjinicolaou, Youxin Kong, Viveka Mayya, Julie M. Mazet, Gracie-Jennah Mead, Joshua A. Bull, Pramila Rijal, Christopher W. Pugh, Alain R. Townsend, Audrey Gérard, Lars R. Olsen, Marco Fritzsche, Tudor A. Fulga, Michael L. Dustin, E. Yvonne Jones, Vincenzo Cerundolo   +27 more
doaj   +1 more source

Sema3A drastically suppresses tumor growth in oral cancer Xenograft model of mice

BMC Pharmacology and Toxicology, 2017
Background Multiple studies suggest anti-angiogenesis to be a promising and rational option in cancer treatment. Interestingly, the axonal sprouting inhibitor semaphorin 3A (Sema3A), a potent suppressor of tumor angiogenesis in various cancer models, is ...
Chao Huang, Yi Wang, Jian-Hua Huang, Weixian Liu   +3 more
doaj   +1 more source