Results 61 to 70 of about 6,782 (204)

Neuronal guidance factor Sema3A inhibits neurite ingrowth and prevents chondrocyte hypertrophy in the degeneration of knee cartilage in mice, monkeys and humans

Bone Research
Osteoarthritis (OA) is a degenerative joint disease accompanied with the loss of cartilage and consequent nociceptive symptoms. Normal articular cartilage maintains at aneural state.
Shishu Huang, Dashuang Gao, Zhenxia Li, Hongchen He, Xi Yu, Xuanhe You, Diwei Wu, Ze Du, Jiancheng Zeng, Xiaojun Shi, Qinshen Hu, Yong Nie, Zhong Zhang, Zeyu Luo, Duan Wang, Zhihe Zhao, Lingli Li, Guanglin Wang, Liping Wang, Zongke Zhou, Di Chen, Fan Yang   +21 more
doaj   +1 more source

Reconsideration of the Semaphorin-3A Binding Motif Found in Chondroitin Sulfate Using Galnac4s-6st-Knockout Mice

Biomolecules, 2020
The chondroitin sulfate (CS)-rich dense extracellular matrix surrounding neuron cell bodies and proximal dendrites in a mesh-like structure is called a perineuronal net (PNN).
Satomi Nadanaka, Shinji Miyata, Bai Yaqiang, Jun-ichi Tamura, Osami Habuchi, Hiroshi Kitagawa   +5 more
doaj   +1 more source

Recent Advances in Natural Polymers‐based Hydrogels for Periodontal Regeneration

Macromolecular Bioscience, Volume 26, Issue 5, May 2026.
Natural polymer‐based hydrogels are emerging as promising biomimetic platforms for periodontal regeneration. This review highlights advances in alginate, collagen, and chitosan hydrogels engineered to modulate inflammation, deliver bioactive agents, and support tissue repair.
João de Freitas Gomes Neto, Tainara de Paula de Lima Lima, Luiza Meurer Brand, Caio Fernando Cardoso Souza, Marcelo Lazzaron Lamers, Pedro L. Granja, Luiz Antonio Pessan, Eduardo Henrique Backes   +7 more
wiley   +1 more source

Semaphorin 3A-hypoxia inducible factor 1 subunit alpha co-overexpression enhances the osteogenic differentiation of induced pluripotent stem cells-derived mesenchymal stem cells in vitro

Chinese Medical Journal, 2020
. Background:. Mesenchymal stem or stromal cells (MSCs) derived from the induced pluripotent stem cells (iPSCs) have uniform biological activity, which makes the clinical application of MSCs in bone repair possible.
Jing-Yi Li, Ting-Ting Wang, Chong Li, Zhi-Fang Wang, Shan Li, Li Ma, Li-Li Zheng, Li-Shao Guo   +7 more
doaj   +1 more source

Sema3a inhibits the differentiation of Raw264.7 cells to osteoclasts under 2Gy radiation by reducing inflammation. [PDF]

PLoS ONE, 2018
Astronauts and cancer patients receive different types of radiation, and radiation decreases bone strength and leads to radiation-induced osteoporosis. This effect is attributed to the activation of osteoclasts.
Bo Huang, Qin Zhang, Ying Yuan, Na Xin, Kun He, Yan Huang, Hua Tang, Ping Gong   +7 more
doaj   +1 more source

Diminished and Altered Cellular Senescence Response in Delayed Wound Healing of Aging

Aging Cell, Volume 25, Issue 5, May 2026.
Acute wound healing in young skin is supported by a transient population of senescent fibroblasts with proreparative, ECM‐remodeling functions. Aging disrupts both the induction and functional identity of these cells, contributing to delayed wound closure and impaired tissue repair.
Maria Shvedova, Rex Jeya Rajkumar Samdavid Thanapaul, Qiaoling Wang, Grace Haeun Shin, Jannat Dhillon, Daniel Sam Roh   +5 more
wiley   +1 more source

miR-181b targets semaphorin 3A to mediate TGF-β–induced endothelial-mesenchymal transition related to atrial fibrillation

The Journal of Clinical Investigation, 2022
Atrial fibrosis is an essential contributor to atrial fibrillation (AF). It remains unclear whether atrial endocardial endothelial cells (AEECs) that undergo endothelial-mesenchymal transition (EndMT) are among the sources of atrial fibroblasts.
Ying-Ju Lai, Feng-Chun Tsai, Gwo-Jyh Chang, Shang-Hung Chang, Chung-Chi Huang, Wei-Jan Chen, Yung-Hsin Yeh   +6 more
doaj   +1 more source

Region‐to‐Region Unidirectional Connection In Vitro Brain Model for Studying Directional Propagation of Neuropathologies

Advanced Functional Materials, Volume 36, Issue 33, 23 April 2026.
A unidirectional cerebral organoid–organoid neural circuit is established using a microfluidic platform, enabling controlled directional propagation of electrical signals, neuroinflammatory cues, and neurodegenerative disease–related proteins between spatially separated organoids.
Kyeong Seob Hwang, Hui‐Wen Liu, Hyogeun Shin, Hyun Wook Kang, Minjin Kang, Jongbaeg Kim, Il‐Joo Cho, Nakwon Choi, Seok Chung, Hong Nam Kim   +9 more
wiley   +1 more source

G93A-hSOD1 ALS mice were bred with the K108N-SEMA3A line to create ALS mice homozygote or heterozygote for the mutant SEMA3A gene.

, 2017
G93A-hSOD1 ALS mice were bred with the K108N-SEMA3A line to create ALS mice homozygote or heterozygote for the mutant SEMA3A gene.
Joost Verhaagen (55754), Fred De Winter (3684880), Barbara Hobo (533803), Elizabeth B. Moloney (3684877)   +3 more
core   +1 more source

Extract of Scutellaria baicalensis induces semaphorin 3A production in human epidermal keratinocytes.

PLoS ONE, 2021
In a disease-state-dependent manner, the histamine-resistant itch in dry skin-based skin diseases such as atopic dermatitis (AD) and xerosis is mainly due to hyperinnervation in the epidermis.
Yasuko Yoshioka, Yayoi Kamata, Mitsutoshi Tominaga, Yoshie Umehara, Ikuyo Yoshida, Nobuya Matsuoka, Kenji Takamori   +6 more
doaj   +1 more source