Results 81 to 90 of about 6,782 (204)

A Transcriptomic Analysis of Cancer‐Stromal Interactome in Lung Cancer Xenograft Models

Cancer Science, Volume 117, Issue 3, Page 841-851, March 2026.
We conducted a comprehensive analysis of the lung cancer interactome to identify key ligand–receptor pairs involved in the aggressiveness of lung adenocarcinoma. Tumor necrosis factor superfamily member 12 and its receptor tumor necrosis factor receptor superfamily member 12A signaling axis may be potential candidates for therapeutic intervention for ...
Yuriko Takayama‐Isagawa, Daisuke Komura, Takayuki Isagawa, Yusuke Amano, Atsushi Kihara, Tamaki Miura, Taichiro Yoshimoto, Hiroyoshi Tsubochi, Kazutaka Fujita, Koichi Hagiwara, Makoto Maemondo, Tetsuo Ushiku, Shumpei Ishikawa, Noriyoshi Fukushima, Kentaro Inamura, Daisuke Matsubara, Toshiro Niki   +16 more
wiley   +1 more source

Lung morphology is abnormal in Sema3A^-/- mice.

, 2013
Top panel. Representative lung histology from Sema3A-/- mice (right panels) and Sema3A+/+ littermate controls (left panels) at E17.5, P1, P14 and P28. Prominent septation defects were seen in all Sema3A-/- mice that survived to P14 or beyond.
Michael J. Delannoy (339732), Patrice M. Becker (339730), Tracy S. Tran (339731), Chaoxia He (339733), John M. Shannon (339734), Sharon McGrath-Morrow (216731)   +5 more
core   +1 more source

A Preliminary Study of the Effect of Semaphorin 3A and Acitretin on the Proliferation, Migration, and Apoptosis of HaCaT Cells

Indian Journal of Dermatology, 2019
Background: Vascular endothelial growth factor (VEGF) is significantly elevated in psoriatic patients and is associated with the severity of the psoriasis.
Wei Ding, Yi Cao, Fengling Xing, Maocan Tao, Hongyang Fu, Hongbin Luo, Xiaohong Yang   +6 more
doaj   +1 more source

Adrenarche as a regulator of sensitivity to early adversity

Journal of Neuroendocrinology, Volume 38, Issue 3, March 2026.
Abstract The human brain is highly sensitive to early adversity, which can have long‐term consequences for later mental health. It is also a time of rapid learning of social, motor and other skills, including language. It is proposed that pre‐adrenarche, the only epoch in human development in which cortisol is not accompanied by dehydroepiandrosterone (
J. Herbert
wiley   +1 more source

Human Atlas of Tooth Decay Progression: Identification of Cellular Mechanisms Driving the Switch from Dental Pulp Repair Toward Irreversible Pulpitis

Advanced Science, Volume 13, Issue 8, 9 February 2026.
Tooth decay progression transforms the dental pulp response from repair to fibrosis. At early stages, stromal cells reprogram to repair the extra cellular matrix (ECM), blood vessels, and nerves, remodel and grow, keeping repair possible. In advanced decay, hypoxia, and vessel regression, in complement with an immune switch, fuel nerve degeneration and
Hoang Thai Ha, Sofya Kosmynina, Amandine Verocq, Keremsah Ozen, Ines Tekia, Hugo Bussy, Marie Ramirez, Dima Sabbah, Chloe Goemans, Valerie Vandenbempt, Esteban N. Gurzov, Sumeet Pal Singh, Nicolas Baeyens   +12 more
wiley   +1 more source

Lung cell death but nor proliferation is altered in Sema3A^-/- mice.

, 2013
A. Widespread immunostaining for the proliferative marker PCNA (green) was seen in lungs from both E17.5 Sema3A+/+ and Sema3A-/- mice (top panels). By P1 (middle panels) and P14 (lower panels), PCNA staining was largely confined to cells lining small ...
Michael J. Delannoy (339732), Patrice M. Becker (339730), Tracy S. Tran (339731), Chaoxia He (339733), John M. Shannon (339734), Sharon McGrath-Morrow (216731)   +5 more
core   +1 more source

Sema3A regulates metastasis through epithelial-mesenchymal transition/matrix metalloproteinase-2 in epithelial ovarian cancer

Zhongguo aizheng zazhi, 2020
Background and purpose: Semaphorin 3A (Sema3A) is initially considered to play an important role in axonal orientation. Recently, Sema3A has also been considered as a candidate tumor suppressor involved in the tumorigenesis. The purpose of this study was
王晓琴, 傅鑫蕾, 马如越, 杨丽娜, 陈亚萍, 张丽文   +5 more
doaj  

Glycolysis enzymes and cellular lactylation in tumour

Clinical and Translational Medicine, Volume 16, Issue 2, February 2026.
Graphical Headlights • Glycolytic enzymes regulate lactylation in cancer cells. • Lactylation drives tumour growth, metastasis, immune evasion and contributes to microenvironment remodelling. • Targeting lactylation holds promise for cancer therapy. Abstract Cellular lactylation, a recently identified post‐translational modification, has emerged as a ...
Chenyuan Dai, Lihua Wang
wiley   +1 more source

Role of the neuropilin ligands VEGF164 and SEMA3A in neuronal and vascular patterning in the mouse.

, 2007
Blood vessels and neurons use similar guidance cues to control their behaviour during embryogenesis. The semaphorin SEMA3A was originally identified as a repulsive cue for developing axons that acts by signalling through receptor complexes containing ...
Joaquim Miguel Vieira, Christiana Ruhrberg, Quenten Schwarz, Schwarz, Q, Vieira, JM, Ruhrberg, C   +5 more
core   +1 more source

Characterization of SEMA3A-encoded semaphorin as a naturally occurring Kv4.3 protein inhibitor and its contribution to Brugada syndrome

, 2014
Semaphorin 3A (SEMA3A)-encoded semaphorin is a chemorepellent that disrupts neural patterning in the nervous and cardiac systems. In addition, SEMA3A has an amino acid motif that is analogous to hanatoxin, an inhibitor of voltage-gated K(+) channels ...
Nerbonne, Jeanne M., Dagradi, Federica, Alders, M., Wang, Wei, Boczek, N.J., Wilde, Arthur A. M., Ye, D., Crotti, L., Boczek, Nicole J., Nerbonne, J.M., Ye, Dan, Ackerman, Michael J., Ackerman, M.J., Wilde, A.A.M., Crotti, Lia, Mizusawa, Y., Torchio, M., Tester, David J., Johnson, E.K., Dagradi, F., Alders, Marielle, Torchio, Margherita, Johnson, Eric K., Mizusawa, Yuka, Schwartz, Peter J., Giudicessi, John R., Schwartz, P.J., Giudicessi, J.R., Tester, D.J., Wang, W.   +29 more
core   +1 more source