Results 91 to 100 of about 6,782 (204)

Cationic Peptides and Peptidomimetics Bind Glycosaminoglycans as Potential Sema3A Pathway Inhibitors

, 2016
Semaphorin3A (Sema3A) is a vertebrate-secreted protein that was initially characterized as a repulsive-guidance cue. Semaphorins have crucial roles in several diseases; therefore, the development of Sema3A inhibitors is of therapeutic interest.
Moure, Alejandra, Bujons, Jordi, Messeguer, Àngel, Corredor, Miriam, Bonet, Roman, Pérez, Yolanda, Domingo, Cecilia, Alfonso, Ignacio   +7 more
core   +1 more source

Semaphorin 3A causes immune suppression by inducing cytoskeletal paralysis in tumour-specific CD8+ T cells

Nature Communications
Semaphorin-3A (SEMA3A) functions as a chemorepulsive signal during development and can affect T cells by altering their filamentous actin (F-actin) cytoskeleton.
Mike B. Barnkob, Yale S. Michaels, Violaine André, Philip S. Macklin, Uzi Gileadi, Salvatore Valvo, Margarida Rei, Corinna Kulicke, Ji-Li Chen, Vitul Jain, Victoria K. Woodcock, Huw Colin-York, Andreas V. Hadjinicolaou, Youxin Kong, Viveka Mayya, Julie M. Mazet, Gracie-Jennah Mead, Joshua A. Bull, Pramila Rijal, Christopher W. Pugh, Alain R. Townsend, Audrey Gérard, Lars R. Olsen, Marco Fritzsche, Tudor A. Fulga, Michael L. Dustin, E. Yvonne Jones, Vincenzo Cerundolo   +27 more
doaj   +1 more source

Influence of SERCA inhibitor thapsigargin (1 µM) on Sema3A (100 ng/mL) induced effects.

, 2014
A) 1 hour incubation with endoplasmic reticulum SERCA inhibitor had no significant effect on growth cones of mouse E15 DRG growth cone collapse rate (red bar) comparing to control conditions (black bar).
Emmanuel Jover (361330), Saulius Šatkauskas (5660005), Andrius Kaselis (599757), Rimantas Treinys (599756), Dominique Bagnard (161355)   +4 more
core   +1 more source

Vascular endothelial growth factor/semaphorin-3A ratio and SEMA3A expression in cutaneous malignant melanoma

, 2020
Breslow thickness and Clark level are still important factors for cutaneous melanoma, but do not provide a precise prognosis in all cases. It is necessary to find new factors capable of a more accurate prediction of the tumor course.
Offidani A., Simonetti O., Goteri G., Giantomassi F., Lazzarini R., Lucarini G.   +5 more
core   +1 more source

Guidance molecule SEMA3A restricts tumor growth by differentially regulating the proliferation of tumor-associated macrophages

, 2016
Accumulation of tumor-associated macrophages (TAM) correlates with malignant progression, immune suppression and poor prognosis. In this study, we defined a critical role for the cell-surface guidance molecule SEMA3A in differential proliferative control
Östman, Arne, Rolny, Charlotte, Wallmann, Tatjana, Mezheyeuski, Artur, Tobin, Nicholas P., Andersson, John, Bergh, Jonas, Pontén, Fredrik, Wallerius, Majken, Pangigadde, Pradeepa, Squadrito, Mario Leonardo, Nygren, Emma, De Palma, Michele, Hartman, Johan, De Milito, Angelo, Bartish, Margarita, Pellegrini, Paola, Östling, Jeanette   +17 more
core   +2 more sources

Induction of Semaphorin 3A by Resveratrol and Pinostilbene via Activation of the AHR-NRF2 Axis in Human Keratinocytes

Antioxidants
Semaphorin 3A (SEMA3A), a nerve-repellent factor produced by keratinocytes, has an inhibitory effect on nerve extension to the epidermis. Epidermal innervation is involved in pruritus in inflammatory skin diseases such as atopic dermatitis (AD) and dry ...
Gaku Tsuji, Ayako Yumine, Koji Kawamura, Masaki Takemura, Takeshi Nakahara   +4 more
doaj   +1 more source

Matrilysin/MMP-7 Cleavage of Perlecan/HSPG2 Complexed with Semaphorin 3A Supports FAK-Mediated Stromal Invasion by Prostate Cancer Cells

Scientific Reports, 2018
Interrupting the interplay between cancer cells and extracellular matrix (ECM) is a strategy to halt tumor progression and stromal invasion. Perlecan/heparan sulfate proteoglycan 2 (HSPG2) is an extracellular proteoglycan that orchestrates tumor ...
Brian J. Grindel, Jerahme R. Martinez, Tristen V. Tellman, Daniel A. Harrington, Hamim Zafar, Luay Nakhleh, Leland W. Chung, Mary C. Farach-Carson   +7 more
doaj   +1 more source

Intranasal Administration of Semaphorin-3A Alleviates Sneezing and Nasal Rubbing in a Murine Model of Allergic Rhinitis

Journal of Pharmacological Sciences, 2011
.: Sneezing and persistent itching of the nasal mucosa are distressing symptoms of allergic rhinitis (AR). Recent studies have revealed that hyperinnervation of sensory neurons in the nasal turbinate is one of the underlying causes of sneezing and ...
Haruna Sawaki, Fumio Nakamura, Michiko Aihara, Yoji Nagashima, Junko Komori-Yamaguchi, Naoya Yamashita, Masatoshi Nakazawa, Yoshio Goshima, Zenro Ikezawa   +8 more
doaj   +1 more source

ISEV2026 Abstract Book

Journal of Extracellular Vesicles, Volume 15, Issue S1, June 2026.
wiley   +1 more source

Alveolar epithelial cell morphology is altered in Sema3A^-/- mice.

, 2013
A. PAS staining was increased in lungs from E17.5 Sema3A-/- mice (right panels) as compared with Sema3A+/+ littermate controls (left panels). Bar  =  10 µ. Results are representative of 3 animals/group. B. TEM confirmed reduced distal airspace size (Alv)
Michael J. Delannoy (339732), Patrice M. Becker (339730), Tracy S. Tran (339731), Chaoxia He (339733), John M. Shannon (339734), Sharon McGrath-Morrow (216731)   +5 more
core   +1 more source