Results 71 to 80 of about 6,782 (204)

Soluble Sema4D From γδ T Cells Exerts Osteoblast Inhibition via Plexin‐B/mTOR Signalling Contributing to Pathogenesis of Bisphosphonate‐Related Osteonecrosis of the Jaws

Cell Proliferation, Volume 59, Issue 4, April 2026.
Schematic summarizing the pathway of sSema4D from γδ T cells inhibiting osteoblast differentiation in BRONJ. ABSTRACT Bisphosphonate‐related osteonecrosis of the jaw (BRONJ) is a severe complication in patients undergoing long‐term bisphosphonate therapy, while our knowledge on the pathogenesis of BRONJ is far from sufficient.
Lingling Ou, Shijia Qiao, Zhuoyi Liao, Xiner Tan, Hui Huang, Zhiyan Zhou, Ruhui Luo, Weijun Zeng, Yan Yang, Zhongxuan Zhang, Jingchen Chen, Shengli Wang, Yiqin Jiang, Jianlei Hao, Yuqin Shen, Longquan Shao   +15 more
wiley   +1 more source

The stimulation of dendrite growth by Sema3A requires integrin engagement and focal adhesion kinase.

, 2009
peer reviewedThe rate and direction of axon and dendrite growth depend on multiple guidance signals and growth factors. Semaphorin 3A (Sema3A) acts as a repellent for axons and attractant for dendrites.
Püschel, A. W., SCHWAMBORN, Jens Christian, Puschel, Andreas W., Schlomann, Uwe, Fässler, R., Fassler, Reinhard, Müller, M., Schwamborn, J. C., Muller, Myriam, Schlomann, U.   +9 more
core   +1 more source

Semaphorin-3A protects against neointimal hyperplasia after vascular injuryResearch in context

EBioMedicine, 2019
Background: Neointimal hyperplasia is a prominent pathological event during in-stent restenosis. Phenotype switching of vascular smooth muscle cells (VSMCs) from a differentiated/contractile to a dedifferentiated/synthetic phenotype, accompanied by ...
Jie-hong Wu, Yi-fan Zhou, Can-dong Hong, An-qi Chen, Yan Luo, Ling Mao, Yuan-peng Xia, Quan-wei He, Hui-juan Jin, Ming Huang, Ya-nan Li, Bo Hu   +11 more
doaj   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, Volume 20, Issue 3, Page 753-778, March 2026.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

ALS-related human cortical and motor neurons survival is differentially affected by Sema3A

, 2018
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by cell death of upper and lower motor neurons (MNs). The cause of MN cell loss is not completely understood but involves both cell autonomous and non-cell autonomous ...
Anastasya Birger, Liat Perez, Benjamin Reubinoff, Miri Ottolenghi, Oded Behar   +4 more
core   +1 more source

Decreased Semaphorin3A expression correlates with disease activity and histological features of rheumatoid arthritis

BMC Musculoskeletal Disorders, 2013
Background Rheumatoid arthritis (RA) is an autoimmune disease of which the pathogenetic mechanisms are not fully understood. Semaphorin3A (Sema3A) has an immune regulatory role.
Takagawa Shu, Nakamura Fumio, Kumagai Ken, Nagashima Yoji, Goshima Yoshio, Saito Tomoyuki   +5 more
doaj   +1 more source

CRISPLD2 Attenuates Intervertebral Disc Degeneration by Suppressing Oxidative Stress‐Induced Ferroptosis through the miR‐548I‐IL17A Axis

Advanced Science, Volume 13, Issue 16, 18 March 2026.
This study identifies CRISPLD2 as a key protector against IVDD. By regulating ferroptosis through the CRISPLD2–miR‐548I–IL17A axis, CRISPLD2 maintains NPCs homeostasis and reduces oxidative stress. Restoring CRISPLD2 expression effectively alleviates disc degeneration and highlights a promising therapeutic strategy for discogenic low back pain ...
Yangyang Shi, Fudong Li, Tianyi Zhao, Kaiqiang Sun, Danying Zhang, Chen Yan, Ximing Xu, Jingchuang Sun, Xulin Hu, Xin Yong, Jiangang Shi, Yuan Wang   +11 more
wiley   +1 more source

MicroRNAs in Methamphetamine: Addiction, Neurotoxicity, and Therapeutic Potential

MedComm – Future Medicine, Volume 5, Issue 1, March 2026.
The use of METH leads to the release of dopamine from the affected brain regions, including the nucleus accumbens (NAc), ventral tegmental area (VTA), prefrontal cortex (PFC), hippocampus (Hip), and striatum. This triggers signals that alter miRNA expression, which in turn leads to differential expression of target genes.
Yacoubou Abdoul Razak Mahaman, An‐Ping Ye, Ya‐Xian Zhang, Ming‐Yu Chen, Fang Huang, Rong Liu, Ying‐Yan Fang, Xiaochuan Wang   +7 more
wiley   +1 more source

Characterization of Konjac Ceramide (kCer) Binding to Sema3A Receptor Nrp1

Journal of Oleo Science, 2018
Konjac ceramide (kCer) can be prepared by a chemoenzymatic method as previously published (Usuki, S.; Tamura, N.; Sakai, S.; Tamura, T.; Mukai, K.; Igarashi, Y. Biochem. Biophys. Rep. 5, 160-167 (2016)). Thus prepared kCer showed an activation effect on Sema3A signaling pathway to induce phosphorylation of CRMP2 and microtubule depolymerizaion ...
Usuki, Seigo, Tamura, Noriko, Tamura, Tomohiro, Mukai, Katsuyuki, Igarashi, Yasuyuki   +4 more
openaire   +3 more sources

Mutation screening of SEMA3A and SEMA7A in patients with congenital hypogonadotropic hypogonadism [PDF]

Pediatric Research, 2014
Congenital hypogonadotropic hypogonadism (HH), a rare disorder characterized by absent, partial, or delayed puberty, can be caused by the lack or deficient number of hypothalamic gonadotropin-releasing hormone (GnRH) neurons. SEMA3A was recently implicated in the etiology of the disorder, and Sema7A-deficient mice have a reduced number of GnRH neurons ...
Laitinen Eeva-Maria, Tommiska Johanna, Kansakoski Johanna, Vaaralahti Kirsi, Hackman Peter, Fagerholm Rainer, Raivio Taneli, Laitinen Eeva-Maria, Tommiska Johanna, Kansakoski Johanna, Vaaralahti Kirsi, Hackman Peter, Fagerholm Rainer, Raivio Taneli   +13 more
openaire   +3 more sources