Results 21 to 30 of about 6,154 (176)
Semaphorins and their receptors in pancreatic cancer: Mechanisms and therapeutic opportunities
Frontiers in Oncology, 2023 Pancreatic cancer (PC) is a malignant tumor with high malignancy that is difficult to diagnose and treat. PC is a major medical problem because of its low early diagnosis rate, high surgical mortality rate, low cure rate, and expensive related testing ...
Dahai Liu +4 more
doaj +1 more source
Association of Immune Semaphorins with COVID-19 Severity and Outcomes
Biomedicines, 2023 Semaphorins have recently been recognized as crucial modulators of immune responses. In the pathogenesis of COVID-19, the activation of immune responses is the key factor in the development of severe disease. This study aimed to determine the association
Martina Vargovic +4 more
doaj +1 more source
Axon Guidance Molecules and Pain
Cells, 2022 Chronic pain is a debilitating condition that influences the social, economic, and psychological aspects of patients’ lives. Hence, the need for better treatment is drawing extensive interest from the research community.
Elisa Damo, Manuela Simonetti
doaj +1 more source
Semaphorins and tumor angiogenesis [PDF]
Angiogenesis, 2009 Semaphorins belong to a large family of proteins well-conserved along evolution from viruses to mammalians. Secreted and membrane-bound semaphorins participate in a wide range of biological phenomena including development and regeneration of nervous system, cardiovascular development, and immune system activities.
Serini, Guido +3 more
openaire +2 more sources
Frontiers in Endocrinology, 2013 The semaphorin proteins are among the best-studied families of guidance cues, contributing to morphogenesis and homeostasis in a wide range of tissue types.
Andrea eMessina, Paolo eGiacobini
doaj +1 more source
Semaphorin 4C accelerates disease progression and enables disease detection in breast cancer
Visualized Cancer Medicine, 2023 Semaphorins constitute a diverse family of widely expressed transmembrane, diffusible, and GPI-linked proteins with versatile physiologic functions in orchestrating nerve system development, immune homeostasis, angiogenesis, and cell metabolism ...
Li Huayi +5 more
doaj +1 more source
Semaphorin Breaks Symmetry [PDF]
Neuron, 2011 Axon-dendrite polarity is likely instructed by extrinsic cues in the developing nervous system, though the mechanisms governing this process remain to be fully elucidated. In this issue of Neuron, Shelly et al. show that the axon guidance cue Semaphorin 3A can promote dendrite growth by inhibiting axon specification.
Howell, Audrey S., Shen, Kang
openaire +2 more sources
Neuroimmune semaphorins as costimulatory molecules and beyond
Molecular Medicine, 2018 Several neuronal guidance proteins, known as semaphorin molecules, function in the immune system. This dual tissue performance has led to them being defined as “neuroimmune semaphorins”.
Svetlana P. Chapoval
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 CHD7 is a chromatin remodeler protein that controls gene expression via the formation of multi-protein complexes with specific transcription factors.
Antonella Lettieri +9 more
doaj +1 more source
BMC Immunology, 2011 Background Semaphorins were originally identified as molecules regulating a functional activity of axons in the nervous system. Sema4A and Sema4D were the first semaphorins found to be expressed on immune cells and were termed "immune semaphorins". It is
Keegan Achsah D +5 more
doaj +1 more source