Results 21 to 30 of about 7,206 (213)
Semaphorin-3D and semaphorin-3E inhibit the development of tumors from glioblastoma cells implanted in the cortex of the brain. [PDF]
PLoS ONE, 2012 Class-3 semaphorins are secreted axon guidance factors. Some of these semaphorins have recently been characterized as suppressors of tumor progression. To determine if class-3 semaphorins can be used to inhibit the development of glioblastoma-multiforme ...
Adi D Sabag +5 more
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SEMAPHORINS and their receptors: focus on the crosstalk between melanoma and hypoxia
Journal of Experimental & Clinical Cancer Research, 2021 Hypoxia, a condition of oxygen deprivation, is considered a hallmark of tumor microenvironment regulating several pathways and promoting cancer progression and resistance to therapy.
Elisabetta Valentini +3 more
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Sema6B, Sema6C, and Sema6D expression and function during mammalian retinal development. [PDF]
PLoS ONE, 2013 In the vertebrate retina, the formation of neural circuits within discrete laminae is critical for the establishment of retinal visual function. Precise formation of retinal circuits requires the coordinated actions of adhesive and repulsive molecules ...
Ryota L Matsuoka +4 more
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Semaphorin-3E/plexinD1 axis in allergic asthma
Advances in Biomedical and Health Sciences, 2022 Semaphorins are cell-membrane bound or secretory proteins that regulate cell migration, differentiation, proliferation, and morphology. Semaphorins are guidance cues that have either repulsive or attractive effects on growth cones and thus determine ...
Mojdeh Matloubi +4 more
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Frontiers in Immunology, 2021 Semaphorins are a group of proteins that have been studied extensively for their critical function in neuronal development. They have been shown to regulate airway development, tumorigenesis, autoimmune diseases, and the adaptive immune response. Notably,
Shreya M. Kanth +2 more
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Semaphorins in Angiogenesis and Autoimmune Diseases: Therapeutic Targets?
Frontiers in Immunology, 2020 The axonal guidance molecules, semaphorins, have been described to function both physiologically and pathologically outside of the nervous system. In this review, we focus on the vertebrate semaphorins found in classes 3 through 7 and their roles in ...
Vijaya Iragavarapu-Charyulu +2 more
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Semaphorin signaling restricts neuronal regeneration in C. elegans
Frontiers in Cell and Developmental Biology, 2022 Extracellular signaling proteins serve as neuronal growth cone guidance molecules during development and are well positioned to be involved in neuronal regeneration and recovery from injury.
Maria B Harreguy +11 more
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Semaphorins and their receptors in pancreatic cancer: Mechanisms and therapeutic opportunities
Frontiers in Oncology, 2023 Pancreatic cancer (PC) is a malignant tumor with high malignancy that is difficult to diagnose and treat. PC is a major medical problem because of its low early diagnosis rate, high surgical mortality rate, low cure rate, and expensive related testing ...
Dahai Liu +4 more
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Association of Immune Semaphorins with COVID-19 Severity and Outcomes
Biomedicines, 2023 Semaphorins have recently been recognized as crucial modulators of immune responses. In the pathogenesis of COVID-19, the activation of immune responses is the key factor in the development of severe disease. This study aimed to determine the association
Martina Vargovic +4 more
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Axon Guidance Molecules and Pain
Cells, 2022 Chronic pain is a debilitating condition that influences the social, economic, and psychological aspects of patients’ lives. Hence, the need for better treatment is drawing extensive interest from the research community.
Elisa Damo, Manuela Simonetti
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