Results 11 to 20 of about 7,206 (213)
Neuroimmune semaphorins as costimulatory molecules and beyond
Molecular Medicine, 2018 Several neuronal guidance proteins, known as semaphorin molecules, function in the immune system. This dual tissue performance has led to them being defined as “neuroimmune semaphorins”.
Svetlana P. Chapoval
doaj +2 more sources
Semaphorins in cardiovascular medicine [PDF]
Trends in Molecular Medicine, 2014 During organogenesis, patterning is primarily achieved by the combined actions of morphogens. Among these, semaphorins represent a general system for establishing the appropriate wiring architecture of biological nets. Originally discovered as evolutionarily conserved steering molecules for developing axons, subsequent studies on semaphorins expanded ...
CORA', Davide +3 more
openaire +4 more sources
Biomedicines, 2022 Nonalcoholic fatty liver disease (NAFLD) is associated with systemic changes in immune response linked with chronic low-grade inflammation and disease progression.
Lara Šamadan +5 more
doaj +2 more sources
Semaphorins in health and disease
Cytokine & Growth Factor Reviews, 2021 Cell-cell communication is pivotal to guide embryo development, as well as to maintain adult tissues homeostasis and control immune response. Among extracellular factors responsible for this function, are the Semaphorins, a broad family of around 20 different molecular cues conserved in evolution and widely expressed in all tissues.
Damon Fard, Luca Tamagnone
openaire +4 more sources
Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells. [PDF]
PLoS ONE, 2008 The class-3 semaphorins (sema3s) include seven family members. Six of them bind to neuropilin-1 (np1) or neuropilin-2 (np2) receptors or to both, while the seventh, sema3E, binds to the plexin-D1 receptor.
Boaz Kigel +3 more
doaj +2 more sources
Semaphorins and Their Receptors in Hematological Malignancies
Frontiers in Oncology, 2019 While semaphorins were initially identified as axonal guidance cues for wiring the neural network, it was then recognized their wide relevance in tissue development and homeostasis.
Li Wei +6 more
doaj +2 more sources
Expression analysis and possible functional roles of semaphorin/plexin/CRMP families in mouse pancreatic islets [PDF]
Scientific ReportsSemaphorins were initially identified as axon guidance molecules that were widely expressed and involved in divergent functions in various organs, including neuronal development and immunological processes.
Mayu Kyohara +13 more
doaj +2 more sources
Pathophysiological functions of semaphorins in the sympathetic nervous system
Inflammation and Regeneration, 2023 Upon exposure to external stressors, the body senses them and activates the sympathetic nervous system (SNS) to maintain the homeostasis, which is known as the “fight-or-flight” response. Recent studies have revealed that the SNS also plays pivotal roles
Yumiko Mizuno +2 more
doaj +2 more sources
Semaphorins and Their Receptors: From Axonal Guidance to Atherosclerosis
Frontiers in Physiology, 2018 Semaphorins are a large family of secreted, transmembrane, or GPI-anchored proteins initially identified as axon guidance cues signaling through their receptors, neuropilins, and plexins.
Shuhong Hu, Shuhong Hu, Li Zhu, Li Zhu
exaly +3 more sources
Immune semaphorins: a new area of semaphorin research [PDF]
Journal of Cell Science, 2003 The semaphorin family comprises soluble and membrane-bound proteins originally identified as axonal guidance cues that function during neuronal development. Emerging evidence suggests that a subset of semaphorins, called'immune semaphorins', function in the immune system. The class IV semaphorins Sema4D/CD100 and Sema4A use CD72 and Tim-2, respectively,
Atsushi, Kumanogoh, Hitoshi, Kikutani
openaire +2 more sources