Results 11 to 20 of about 6,154 (176)
Semaphorins and Their Receptors: From Axonal Guidance to Atherosclerosis
Frontiers in Physiology, 2018 Semaphorins are a large family of secreted, transmembrane, or GPI-anchored proteins initially identified as axon guidance cues signaling through their receptors, neuropilins, and plexins.
Shuhong Hu, Shuhong Hu, Li Zhu, Li Zhu
exaly +3 more sources
Successful inhibition of tumor development by specific class-3 semaphorins is associated with expression of appropriate semaphorin receptors by tumor cells. [PDF]
PLoS ONE, 2008 The class-3 semaphorins (sema3s) include seven family members. Six of them bind to neuropilin-1 (np1) or neuropilin-2 (np2) receptors or to both, while the seventh, sema3E, binds to the plexin-D1 receptor.
Boaz Kigel +3 more
doaj +1 more source
Semaphorin-3D and semaphorin-3E inhibit the development of tumors from glioblastoma cells implanted in the cortex of the brain. [PDF]
PLoS ONE, 2012 Class-3 semaphorins are secreted axon guidance factors. Some of these semaphorins have recently been characterized as suppressors of tumor progression. To determine if class-3 semaphorins can be used to inhibit the development of glioblastoma-multiforme ...
Adi D Sabag +5 more
doaj +1 more source
SEMAPHORINS and their receptors: focus on the crosstalk between melanoma and hypoxia
Journal of Experimental & Clinical Cancer Research, 2021 Hypoxia, a condition of oxygen deprivation, is considered a hallmark of tumor microenvironment regulating several pathways and promoting cancer progression and resistance to therapy.
Elisabetta Valentini +3 more
doaj +1 more source
Sema6B, Sema6C, and Sema6D expression and function during mammalian retinal development. [PDF]
PLoS ONE, 2013 In the vertebrate retina, the formation of neural circuits within discrete laminae is critical for the establishment of retinal visual function. Precise formation of retinal circuits requires the coordinated actions of adhesive and repulsive molecules ...
Ryota L Matsuoka +4 more
doaj +1 more source
Semaphorin-3E/plexinD1 axis in allergic asthma
Advances in Biomedical and Health Sciences, 2022 Semaphorins are cell-membrane bound or secretory proteins that regulate cell migration, differentiation, proliferation, and morphology. Semaphorins are guidance cues that have either repulsive or attractive effects on growth cones and thus determine ...
Mojdeh Matloubi +4 more
doaj +1 more source
Frontiers in Immunology, 2021 Semaphorins are a group of proteins that have been studied extensively for their critical function in neuronal development. They have been shown to regulate airway development, tumorigenesis, autoimmune diseases, and the adaptive immune response. Notably,
Shreya M. Kanth +2 more
doaj +1 more source
Immune semaphorins: a new area of semaphorin research [PDF]
Journal of Cell Science, 2003 The semaphorin family comprises soluble and membrane-bound proteins originally identified as axonal guidance cues that function during neuronal development. Emerging evidence suggests that a subset of semaphorins, called'immune semaphorins', function in the immune system. The class IV semaphorins Sema4D/CD100 and Sema4A use CD72 and Tim-2, respectively,
Atsushi, Kumanogoh, Hitoshi, Kikutani
openaire +2 more sources
Semaphorins in Angiogenesis and Autoimmune Diseases: Therapeutic Targets?
Frontiers in Immunology, 2020 The axonal guidance molecules, semaphorins, have been described to function both physiologically and pathologically outside of the nervous system. In this review, we focus on the vertebrate semaphorins found in classes 3 through 7 and their roles in ...
Vijaya Iragavarapu-Charyulu +2 more
doaj +1 more source
Semaphorin signaling restricts neuronal regeneration in C. elegans
Frontiers in Cell and Developmental Biology, 2022 Extracellular signaling proteins serve as neuronal growth cone guidance molecules during development and are well positioned to be involved in neuronal regeneration and recovery from injury.
Maria B Harreguy +11 more
doaj +1 more source