Results 31 to 40 of about 7,206 (213)
Semaphorins and tumor angiogenesis [PDF]
Angiogenesis, 2009 Semaphorins belong to a large family of proteins well-conserved along evolution from viruses to mammalians. Secreted and membrane-bound semaphorins participate in a wide range of biological phenomena including development and regeneration of nervous system, cardiovascular development, and immune system activities.
Serini, Guido +3 more
openaire +2 more sources
Semaphorin Breaks Symmetry [PDF]
Neuron, 2011 Axon-dendrite polarity is likely instructed by extrinsic cues in the developing nervous system, though the mechanisms governing this process remain to be fully elucidated. In this issue of Neuron, Shelly et al. show that the axon guidance cue Semaphorin 3A can promote dendrite growth by inhibiting axon specification.
Howell, Audrey S., Shen, Kang
openaire +2 more sources
Frontiers in Endocrinology, 2013 The semaphorin proteins are among the best-studied families of guidance cues, contributing to morphogenesis and homeostasis in a wide range of tissue types.
Andrea eMessina, Paolo eGiacobini
doaj +1 more source
Semaphorin 4C accelerates disease progression and enables disease detection in breast cancer
Visualized Cancer Medicine, 2023 Semaphorins constitute a diverse family of widely expressed transmembrane, diffusible, and GPI-linked proteins with versatile physiologic functions in orchestrating nerve system development, immune homeostasis, angiogenesis, and cell metabolism ...
Li Huayi +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2021 CHD7 is a chromatin remodeler protein that controls gene expression via the formation of multi-protein complexes with specific transcription factors.
Antonella Lettieri +9 more
doaj +1 more source
Semaphorins in Lung Cancer [PDF]
Journal of Thoracic Oncology, 2006 The secreted class 3 semaphorins, which include SEMA3F, a tumor-suppressor gene in lung cancer, were initially identified as molecules involved in the repulsion of developing nerve growth cones. These molecules are part of a larger family that includes transmembrane and membrane-associated proteins, some of which are expressed widely and implicated in ...
Clarhaut, Jonathan +2 more
openaire +2 more sources
BMC Immunology, 2011 Background Semaphorins were originally identified as molecules regulating a functional activity of axons in the nervous system. Sema4A and Sema4D were the first semaphorins found to be expressed on immune cells and were termed "immune semaphorins". It is
Keegan Achsah D +5 more
doaj +1 more source
Genome biology, 2006 Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-rich semaphorin protein domains, that have important roles in a variety of tissues. Humans have 20 semaphorins, Drosophila has five, and two are known from DNA viruses; semaphorins are also found in nematodes and crustaceans but not in non-animals.
Yazdani, Umar, Terman, Jonathan R
openaire +2 more sources
Tgfbr2 in Dental Pulp Cells Guides Neurite Outgrowth in Developing Teeth
Frontiers in Cell and Developmental Biology, 2022 Transforming growth factor β (TGFβ) plays an important role in tooth morphogenesis and mineralization. During postnatal development, the dental pulp (DP) mesenchyme secretes neurotrophic factors that guide trigeminal nerve fibers into and throughout the ...
Monica Stanwick +11 more
doaj +1 more source
Semaphorins: From Angiogenesis to Inflammation in Rheumatoid Arthritis
, 2021 International audienceObjective: To study the potential role of semaphorins in the pathogenesis of rheumatoid arthritis (RA).Methods: Microarray experiments were performed on Affymetrix GeneChip Human Exon 1.0 ST arrays in RA endothelial cells (ECs) and ...
Mouterde, Gaël +8 more
core +1 more source