Results 31 to 40 of about 6,154 (176)
Genome biology, 2006 Semaphorins are secreted, transmembrane, and GPI-linked proteins, defined by cysteine-rich semaphorin protein domains, that have important roles in a variety of tissues. Humans have 20 semaphorins, Drosophila has five, and two are known from DNA viruses; semaphorins are also found in nematodes and crustaceans but not in non-animals.
Yazdani, Umar, Terman, Jonathan R
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Tgfbr2 in Dental Pulp Cells Guides Neurite Outgrowth in Developing Teeth
Frontiers in Cell and Developmental Biology, 2022 Transforming growth factor β (TGFβ) plays an important role in tooth morphogenesis and mineralization. During postnatal development, the dental pulp (DP) mesenchyme secretes neurotrophic factors that guide trigeminal nerve fibers into and throughout the ...
Monica Stanwick +11 more
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Semaphorins in Lung Cancer [PDF]
Journal of Thoracic Oncology, 2006 The secreted class 3 semaphorins, which include SEMA3F, a tumor-suppressor gene in lung cancer, were initially identified as molecules involved in the repulsion of developing nerve growth cones. These molecules are part of a larger family that includes transmembrane and membrane-associated proteins, some of which are expressed widely and implicated in ...
Clarhaut, Jonathan +2 more
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Biomedicines, 2022 Nonalcoholic fatty liver disease (NAFLD) is associated with systemic changes in immune response linked with chronic low-grade inflammation and disease progression.
Lara Šamadan +5 more
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Plexin-B2 controls the timing of differentiation and the motility of cerebellar granule neurons
eLife, 2021 Plexin-B2 deletion leads to aberrant lamination of cerebellar granule neurons (CGNs) and Purkinje cells. Although in the cerebellum Plexin-B2 is only expressed by proliferating CGN precursors in the outer external granule layer (oEGL), its function in ...
Eljo Van Battum +5 more
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Role of Semaphorins in Ischemic Stroke
Frontiers in Molecular Neuroscience, 2022 Ischemic stroke is one of the major causes of neurological morbidity and mortality in the world. Although the management of ischemic stroke has been improved significantly, it still imposes a huge burden on the health and property.
Huaping Du, Yuan Xu, Li Zhu, Li Zhu
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The role of semaphorins in allergic diseases
Allergology InternationalSemaphorins were originally identified as guidance molecules in neural development. However, accumulating evidence indicates that ‘immune semaphorins’ are critically involved in regulating immune cell activation, differentiation, mobility and migration ...
Maiko Naito, Atsushi Kumanogoh
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Advanced Science, EarlyView.The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang +12 more
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Acta Medica BulgaricaSemaphorins, initially identified as phylogenetically conserved axon guidance molecules, comprise an extracellular signaling protein family involved in various biological events that regulate the development, tissue homeostasis and cancer progression of ...
Popov Ts.
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Single‐cell atlas of neuroglial dynamics in SNCA‐A53T Parkinson's disease mouse model
Animal Models and Experimental Medicine, EarlyView.We performed single‐cell RNA sequencing of midbrain and striatal tissues from SNCA‐A53T Parkinson's disease (PD) mice, revealing glia‐enriched PD‐risk gene signatures and disease‐specific subpopulations. Transcriptional dysregulation of key TFs (e.g., Rorb, Foxc1) and enhanced neuroinflammatory signaling (SEMA, CCL, MIF) were identified.
Binqing Qin +7 more
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