Results 41 to 50 of about 9,266 (196)

Neuropilin-1/GIPC1 signaling regulates α5β1 integrin traffic and function in endothelial cells [PDF]

, 2009
Neuropilin 1 (Nrp1) is a coreceptor for vascular endothelial growth factor A165 (VEGF-A165, VEGF-A164 in mice) and semaphorin 3A (SEMA3A). Nevertheless, <i>Nrp1</i> null embryos display vascular defects that differ from those of mice lacking ...
Caccavari, Francesca, Valdembri, D., Serini, G., Valdembri, Donatella, Caccavari, F., Caswell Patrick T, Anderson, K.I., Humphries, M.J., Patrick T Caswell, Anderson Kurt I, Anderson, Kurt I., Serini, Guido, Caccavari Francesca, Federico Bussolino, Elena Astanina, Valdembri Donatella, König, I., König, Ireen, Astanina, Elena, Schwarz, J.P., Francesca Caccavari, Jim C Norman, Humphries Martin J, Bussolino, F., Schwarz Juliane P, Guido Serini, Serini Guido, König Ireen, Schwarz, Juliane P., Bussolino, Federico, Kurt I Anderson, Humphries, Martin J., Caswell, Patrick T.; id_orcid, Norman, Jim C., Juliane P Schwarz, Astanina Elena, Astanina, E., Bussolino Federico, Norman, J.C., Donatella Valdembri, Caswell, P.T., Ireen König, Norman Jim C, Martin J Humphries   +43 more
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SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome.

PLoS Genetics, 2012
Kallmann syndrome (KS) associates congenital hypogonadism due to gonadotropin-releasing hormone (GnRH) deficiency and anosmia. The genetics of KS involves various modes of transmission, including oligogenic inheritance.
Naresh Kumar Hanchate, Paolo Giacobini, Pierre Lhuillier, Jyoti Parkash, Cécile Espy, Corinne Fouveaut, Chrystel Leroy, Stéphanie Baron, Céline Campagne, Charlotte Vanacker, Francis Collier, Corinne Cruaud, Vincent Meyer, Alfons García-Piñero, Didier Dewailly, Christine Cortet-Rudelli, Ksenija Gersak, Chantal Metz, Gérard Chabrier, Michel Pugeat, Jacques Young, Jean-Pierre Hardelin, Vincent Prevot, Catherine Dodé   +23 more
doaj   +1 more source

{alpha}2-Chimaerin, cyclin-dependent kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse

, 2004
Neurite outgrowth is influenced by positive and negative signals that include the semaphorins, an important family of axonal outgrowth inhibitors. Here we report that the Rac GTPase activating protein (GAP){alpha}2-chimaerin is involved in Semaphorin 3A (
Eickholt, B, Teo, M, Lim, L, Ferrari, G, Eickholt, Britta, Jacobs, Tom, Leung, Thomas, Jacobs, T., Leung, T., Leung, T, Eickholt, B., Lim, L., Hall, Christine, Qi, R Z, Teo, M., Monfries, C, Jacobs, T, Brown, Matthew, Monfries, Clinton, Teo, Mabel, Qi, Robert Z., Ferrari, G., Qi, R.Z., Lim, Louis, Brown, M., Hall, C., Ferrari, Giovanna, Hall, C, Brown, M, Monfries, C.   +29 more
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The Response of Chick Retinal Ganglion Cells to Semaphorin 3A: potential Semaphorin 3A receptors and effects of BDNF and CNTF

, 2022
In the developing nervous system, axons are guided towards their targets by guidance cues. The guidance molecule Semaphorin 3A is a repulsive axon guidance molecule for many axons.
Hermanova, Eva
core  

Inflammatory Semaphorins in the Pathogenesis and Prognosis of Acute Ischemic Stroke

Medicina
Background and Objectives: Semaphorins are immunoregulatory proteins involved in inflammation and neurovascular modulation. Their roles in ischemic stroke pathogenesis and prognosis have recently gained attention.
Esen Çiçekli, Dilcan Kotan, Levent Avcı   +2 more
doaj   +1 more source

Semaphorins and Their Receptors in Hematological Malignancies

Frontiers in Oncology, 2019
While semaphorins were initially identified as axonal guidance cues for wiring the neural network, it was then recognized their wide relevance in tissue development and homeostasis.
Li Wei, Hongbo Li, Luca Tamagnone, Luca Tamagnone, Hua You, Hua You, Hua You   +6 more
doaj   +1 more source

Semaphorin-3A, semaphorin-7A gene single nucleotide polymorphisms, and systemic lupus erythematosus susceptibility

, 2019
Background: Semaphorin-3A (Sema3A) and Semaphorin-7A (Sema7A) play crucial roles in immune system by inhibiting T cell proliferation and leading to the secretion of pro-inflammatory cytokines.
Hai-Feng Pan (112460), Yan-Feng Zou (835100), Yuzhou Zhang (261075), Jian Cheng (48763), Li-Na Liu (418572), Wenbiao Hu (16913), Peng Wang (34436), Zhiwei Xu (294494)   +7 more
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Secreted human amyloid precursor protein binds semaphorin 3a and prevents semaphorin-induced growth cone collapse. [PDF]

PLoS ONE, 2011
The amyloid precursor protein (APP) is well known for giving rise to the amyloid-β peptide and for its role in Alzheimer's disease. Much less is known, however, on the physiological roles of APP in the development and plasticity of the central nervous ...
Margaret H Magdesian, Matthias Gralle, Luiz H Guerreiro, Paulo José I Beltrão, Milena M V F Carvalho, Luís Eduardo da S Santos, Fernando G de Mello, Ricardo A M Reis, Sérgio T Ferreira   +8 more
doaj   +1 more source

Semaphorin 3A elevates endothelial cell permeability through PP2A inactivation

, 2012
International audienceVE-cadherin-mediated cell-cell junction weakening increases paracellular permeability in response to both angiogenic and inflammatory stimuli.
Dubois, Sonia, Le Guelte, Armelle, Chneiweiss, Herve, Galan-Moya, Eva-Maria, Dwyer, Julie, Auffray, Cedric, Treps, Lucas, Gavard, Julie, Bidere, Nicolas, Hebda, Jagoda K., Kettler, Garance   +10 more
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Immunohistochemical localization of semaphorin 3A in kidney after different treatments.

, 2013
Immunohistochemical localization of semaphorin 3A was carried out as described in Materials and Methods. Immunostaining for semaphorin 3A is seen in thick ascending limb of the loop of Henle and distal tubular epithelial cells. Scale Bar: 100 µM.
Calpurnia Jayakumar (341127), Catherine D. Krawczeski (385223), Punithavathi Ranganathan (385222), Ganesan Ramesh (341131), Prasad Devarajan (38870), Stephen Looney (237505)   +5 more
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