Results 51 to 60 of about 8,560 (166)

Semaphorin 3A suppresses tumor growth and metastasis in mice melanoma model. [PDF]

PLoS ONE, 2012
BACKGROUND: Recent understanding on cancer therapy indicated that targeting metastatic signature or angiogenic switch could be a promising and rational approach to combat cancer.
Goutam Chakraborty, Santosh Kumar, Rosalin Mishra, Tushar V Patil, Gopal C Kundu   +4 more
doaj   +1 more source

Neurodevelopmental Phenotypes and Brain Anomalies in Individuals With Heterozygous SEMA6A Variants

Clinical Genetics, Volume 110, Issue 3, Page 325-335, September 2026.
SEMA6A plays a role in cell migration and axon guidance in the developing central nervous system. Phenotypes seen in eleven individuals heterozygous for SEMA6A variants included developmental delay, intellectual disability, autism/autistic behaviors, behavioral abnormalities, attention disorders, hypotonia, and brain anomalies.
Evan Burchfiel, Xiaonan Zhao, Nichole M. Owen, Tia Gordon, Mahshid S. Azamian, Eric C. Kao, Fan Xia, Xi Luo, Jill A. Rosenfeld, Seema R. Lalani, Allison P. Ortega, Steven B. Bleyl, Florence Petit, Sulekha Rajagopolan, Bénédicte Demeer, Meredith K. Gillespie, Lijia Huang, Matthew Osmond, Kym M. Boycott, Kyra E. Stuurman, Marjon A. van Slegtenhorst, Haley Soller, Céline Jost, Aurore Garde, Hana Safraou, Laurence Faivre, Victor Faundes, Daryl A. Scott   +27 more
wiley   +1 more source

Semaphorin 3A Is Required for Guidance of Olfactory Axons in Mice [PDF]

The Journal of Neuroscience, 2000
Semaphorin 3A (Sema3A) is a membrane-associated secreted protein that has chemorepulsive properties for neuropilin-1 (npn-1)- expressing axons. Although mice lacking the Sema3A protein display skeletal abnormalities and heart defects, most axonal projections in the CNS develop normally.
G A, Schwarting, C, Kostek, N, Ahmad, C, Dibble, L, Pays, A W, Püschel   +5 more
openaire   +2 more sources

Intranasal Administration of Semaphorin-3A Alleviates Sneezing and Nasal Rubbing in a Murine Model of Allergic Rhinitis

Journal of Pharmacological Sciences, 2011
.: Sneezing and persistent itching of the nasal mucosa are distressing symptoms of allergic rhinitis (AR). Recent studies have revealed that hyperinnervation of sensory neurons in the nasal turbinate is one of the underlying causes of sneezing and ...
Haruna Sawaki, Fumio Nakamura, Michiko Aihara, Yoji Nagashima, Junko Komori-Yamaguchi, Naoya Yamashita, Masatoshi Nakazawa, Yoshio Goshima, Zenro Ikezawa   +8 more
doaj   +1 more source

Neighboring Gulf Killifish (Fundulus grandis) Populations Differ in Their Plastic and Genetic Responses to Salinity Fluctuations

Ecology and Evolution, Volume 16, Issue 8, August 2026.
Coastal development can alter the salinity fluctuations experienced by tidal creek systems. Understanding how resident organisms, such as the Gulf killifish, respond to these changes is critical, as development along the coastline is projected to triple in the coming decades.
Antrelle D. Clark, Adam Hallaj, Christopher J. Anderson, Moisés A. Bernal   +3 more
wiley   +1 more source

Differential expression of the semaphorin 3A pathway in prostatic cancer [PDF]

Histopathology, 2009
Aims:  To analyse the expression pattern of the semaphorin 3A (Sema3A) pathway, including the receptor neuropilin 1 (NRP1) and its ligands the ‘antitumoral’ Sema3A and the ‘protumoral’ vascular endothelial growth factor (VEGF)in prostatic cancer.Methods and results:  tissues were obtained from 120 patients treated by prostatectomy for clinically ...
Mokrane, Yacoub, Alix, Coulon, Olivier, Celhay, Jacques, Irani, Olivier, Cussenot, Gaelle, Fromont   +5 more
openaire   +2 more sources

Plasma Membrane Remodeling During Microglial Activation: A Hypothesis Linking Microglial Shape and Lipid Droplet Formation

Glia, Volume 74, Issue 8, August 2026.
Microglial morphology changes in response to damage by Aβ and aging result in significant reductions in cell surface area. Transcriptomic analyses suggest that fatty acid synthesis and triacylglycerol formation drive redistribution of surface membrane into intracellular lipid droplets.
G. William Rebeck, Giorgi Shautidze, Jordy Sepulveda, Gracie S. Healey, Priyanka S. Narayan   +4 more
wiley   +1 more source

The effect of aerobic exercise and psilocybin following methamphetamine induction on the gene expression of certain semaphorins in female Wistar rats [PDF]

Medical Laboratory Journal
Background: The purpose of the present study was to investigate the effect of aerobic exercise and psilocybin after methamphetamine induction on the gene expression of certain cerebral cortex semaphorins in female Wistar rats.
Fariba Rasannezhad, Asieh Abbassi Daloii, Javad Ziaolhagh, Ahmad Abdi   +3 more
doaj  

Semaphorin-3 Promotes Specific Immunotherapy Effects on Experimental Food Allergy

Journal of Immunology Research, 2022
Sustaining higher frequency of mast cells in the allergic lesion site has been recognized. Factors causing high numbers of mast cells in the local tissues are not fully understood yet.
Huang Huang, Yu Liu, Yanan Wang, Huazhen Liu, Bailing Xie, Michael B. W. Zheng, Liteng Yang, Qinmiao Huang, Yongjin Wu, Gaohui Wu, Pengyuan Zheng, Pingchang Yang   +11 more
doaj   +1 more source

Lymphatic Endothelial Cells in Health and Disease

MedComm, Volume 7, Issue 8, August 2026.
Lymphatic endothelial cells (LECs) are dynamic regulators of tissue homeostasis and disease remodeling. In the healthy state, LECs coordinate interstitial fluid drainage, intestinal lipid transport, and immune trafficking and tolerance. Across disease settings, however, these same programs become maladaptively reprogrammed, contributing to barrier ...
Du Tang, Wang Lin, Hengyang Liu, Jixin Zhong, Shiliang Li, Xiaoquan Rao   +5 more
wiley   +1 more source