Results 61 to 70 of about 8,560 (166)

The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity

Neural Plasticity, 2016
During postnatal development, closure of critical periods coincides with the appearance of extracellular matrix structures, called perineuronal nets (PNN), around various neuronal populations throughout the brain.
F. de Winter, J. C. F. Kwok, J. W. Fawcett, T. T. Vo, D. Carulli, J. Verhaagen   +5 more
doaj   +1 more source

Negative Regulation of Semaphorin-3A Expression in Peripheral Blood Mononuclear Cells Using MicroRNA-497-5p [PDF]

Iranian Journal of Medical Sciences, 2019
Background: Semaphorin-3A (Sema3A), as a secreted semaphorin, is an immune modulator molecule participating in the pathogenesis of autoimmune diseases. MicroRNAs (miRNAs) modulate the target-gene expression at the post-transcriptional level.
Shima Shapoori, Mazdak Ganjalikhani-Hakemi, Mahsa Rezaeepoor, Fereshteh Alsahebfosoul, Sharifeh Khosravi, Masoud Etemadifar, Marjan Mansourian   +6 more
doaj   +1 more source

Pancreatic cancer cachexia promotes cardiac dysfunction through altered adrenergic signalling in the heart

The Journal of Physiology, Volume 604, Issue 15, Page 6281-6301, 1 August 2026.
Abstract figure legend The β1‐adrenergic receptor is the predominant adrenergic subtype expressed on cardiac myocytes. Upon stimulation it activates downstream signalling pathways that increase the heart rate and cardiac output to meet metabolic demands.
Parham Diba, Peter R. Levasseur, Samuel D. Newton, Khia Min Sabrina Koh, Paige C. Arneson‐Wissink, Xinxia Zhu, Peter Pham, Heike Mendez, Luke Whitcomb, Ariana Sattler, William R Woodward, Beth A. Habecker, Daniel L. Marks, Aaron J. Grossberg   +13 more
wiley   +1 more source

Sema3E‐plexinD1 Axis Is a Modulator of Foxp3+ Regulatory T‐Cells in House Dust Mite Model of Asthma

The FASEB Journal, Volume 40, Issue 14, 31 July 2026.
Airway epithelial‐derived Sema3E enhances both the number and proliferation of Foxp3+ regulatory T (Treg) cells in an acute model of asthma. Mechanistically, deletion of PlexinD1, the receptor for Sema3E, specifically in Foxp3+ cells was associated with a breakdown in immune regulation in this model.
Mojdeh Matloubi, Chukwunonso Onyilagha, Lianyu Shan, Sujata Basu, Andrew J. Halayko, Mohamed Almiski, Abdelilah S. Gounni   +6 more
wiley   +1 more source

Expression of Semaphorin 3A and Neuropilin 1 in Asthma

Journal of Korean Medical Science, 2013
Neuropilin 1 (NP1) is a part of essential receptor complexes mediating both semaphorin3A (SEMA3A) and vascular endothelial growth factor (VEGF) which is one of important mediators involved in the pathogenesis of asthma. Therefore, it is possible that SEMA3A plays a role in the pathogenesis of asthma through attenuation of VEGF-mediated effects.
Shim, Eun-Jin, Chun, Eunyoung, Kang, Hae-Ryun, Cho, Sang-Heon, Min, Kyung-Up, Park, Heung-Woo   +5 more
openaire   +2 more sources

The Synthetic Melanocortin Agonist NDP‐MSH Ameliorates THSD7A‐Associated Membranous Nephropathy in an Active Immunization Mouse Model

The FASEB Journal, Volume 40, Issue 13, 15 July 2026.
Active immunization with recombinant THSD7A in mice induces autoreactive B cell activation and differentiation into CD138+ antibody‐secreting cells, leading to the production of anti‐THSD7A autoantibodies, glomerular immune injury and proteinuria, characteristic of membranous nephropathy. NDP‐MSH treatment modulates the MITF/IRF4 axis in primed B cells,
Mingzhuo Zhang, Mengxuan Chen, Yan Ge, William Gunning, Rujun Gong   +4 more
wiley   +1 more source

Semaphorin 3A Inhibits Inflammation in Chondrocytes under Excessive Mechanical Stress

Mediators of Inflammation, 2018
Background. Excessive mechanical stress causes inflammation and destruction of cartilage and is considered one of the cause of osteoarthritis (OA).
Chikako Sumi, Naoto Hirose, Makoto Yanoshita, Mami Takano, Sayuri Nishiyama, Yuki Okamoto, Yuki Asakawa, Kotaro Tanimoto   +7 more
doaj   +1 more source

Brain endothelial cells control fertility through ovarian-steroid-dependent release of semaphorin 3A. [PDF]

PLoS Biology, 2014
Neuropilin-1 (Nrp1) guides the development of the nervous and vascular systems, but its role in the mature brain remains to be explored. Here we report that the expression of the 65 kDa isoform of Sema3A, the ligand of Nrp1, by adult vascular endothelial
Paolo Giacobini, Jyoti Parkash, Céline Campagne, Andrea Messina, Filippo Casoni, Charlotte Vanacker, Fanny Langlet, Barbara Hobo, Gabriella Cagnoni, Sarah Gallet, Naresh Kumar Hanchate, Danièle Mazur, Masahiko Taniguchi, Massimiliano Mazzone, Joost Verhaagen, Philippe Ciofi, Sébastien G Bouret, Luca Tamagnone, Vincent Prevot   +18 more
doaj   +1 more source

Integrative Multi‐Omics Analysis Reveals the Tumor‐Suppressive and Immunoregulatory Roles of SEMA5B in Prostate Cancer

BioFactors, Volume 52, Issue 4, July/August 2026.
This study identifies SEMA5B as a tumor suppressor in prostate cancer that suppresses the malignant phenotype, affects mitochondrial oxidative metabolism, induces cell cycle arrest and apoptosis, and is associated with the immune‐inflammatory tumor microenvironment, highlighting its potential as a biomarker and target for immunotherapy. ABSTRACT SEMA5B
Zhiguo Fan, Yihaoyun Lou, Xuan Zhou, Guang Liu, Xiaomin Zhang, Yuanjie Tang, Zhen Zhu, Shancheng Ren, Yifan Chang   +8 more
wiley   +1 more source

Overcoming Barriers to Axonal Regeneration in Spinal Cord Injury: Mechanistic Insights and Therapeutic Frontiers

CNS Neuroscience &Therapeutics, Volume 32, Issue 7, July 2026.
This review summarizes the key intrinsic and extrinsic barriers to axonal regeneration after spinal cord injury and outlines current strategies to rebuild a growth‐permissive microenvironment and enhance neuronal regenerative capacity. ABSTRACT Background Spinal cord injury (SCI) is a devastating central nervous system disorder that often causes ...
Jiaxin Gao, Tian Li, Qingping Su, Cai Jiang, Zhonghua Lin   +4 more
wiley   +1 more source