Results 21 to 30 of about 9,266 (196)
An increase in Semaphorin 3A biases the axonal direction and induces an aberrant dendritic arborization in an in vitro model of human neural progenitor differentiation [PDF]
Cell & Bioscience, 2022 Background Semaphorins (Sema) belong to a large family of repellent guidance cues instrumental in guiding axons during development. In particular, Class 3 Sema (Sema 3) is among the best characterized Sema family members and the only produced as secreted
Gabriella Ferretti +5 more
doaj +2 more sources
Induction of Semaphorin 3A by Resveratrol and Pinostilbene via Activation of the AHR-NRF2 Axis in Human Keratinocytes [PDF]
AntioxidantsSemaphorin 3A (SEMA3A), a nerve-repellent factor produced by keratinocytes, has an inhibitory effect on nerve extension to the epidermis. Epidermal innervation is involved in pruritus in inflammatory skin diseases such as atopic dermatitis (AD) and dry ...
Gaku Tsuji +4 more
doaj +2 more sources
Lipid remodeling and circulating semaphorin 3A in diminished ovarian reserve [PDF]
Scientific ReportsDiminished ovarian reserve (DOR) lacks strong plasma biomarkers, and recent studies have implicated lipid remodeling in its pathophysiology. In our previous study, we noted elevated circulating levels of semaphorin 3A (SEMA3A) in women with DOR ...
S. Serafini +5 more
doaj +2 more sources
Inhibition of CNS Remyelination by the Presence of Semaphorin 3A [PDF]
The Journal of Neuroscience, 2011 Failure of oligodendrocyte precursor cell (OPC) differentiation has been recognized as the leading cause for the failure of myelin regeneration in diseases such as multiple sclerosis (MS). One explanation for the failure of OPC differentiation in MS is the presence of inhibitory molecules in demyelinated lesions. So far only a few inhibitory substrates
Syed, Y. +6 more
openaire +6 more sources
Role of Neuropilin-1/Semaphorin-3A signaling in the functional and morphological integrity of the cochlea. [PDF]
PLoS Genetics, 2017 Neuropilin-1 (Nrp1) encodes the transmembrane cellular receptor neuropilin-1, which is associated with cardiovascular and neuronal development and was within the peak SNP interval on chromosome 8 in our prior GWAS study on age-related hearing loss (ARHL)
Pezhman Salehi +15 more
doaj +3 more sources
Autoimmunity, 2019 Background: Semaphorin-3A (Sema3A) and Semaphorin-7A (Sema7A) play crucial roles in immune system by inhibiting T cell proliferation and leading to the secretion of pro-inflammatory cytokines.
Li-Na Liu, Peng Wang, Yan-Feng Zou
exaly +2 more sources
Basic and Clinical Neuroscience, 2021 Introduction: Semaphorin 3A (Sema 3A) is a secreted protein, which plays an integral part in developing the nervous system. It has collapse activity on the growth cone of dorsal root ganglia.
Keivan Nedaei +4 more
doaj +1 more source
Indian Journal of Rheumatology, 2022 Background: Semaphorin-3A (Sema-3A) is an important immunoregulator protein; it has a role in the maintenance of self-tolerance, so it is thought to be involved in the pathogenesis of many autoimmune diseases such as systemic lupus erythematosus (SLE ...
Alaa Saber Shams +3 more
doaj +2 more sources
Semaphorin 3A suppresses tumor growth and metastasis in mice melanoma model. [PDF]
PLoS ONE, 2012 BACKGROUND: Recent understanding on cancer therapy indicated that targeting metastatic signature or angiogenic switch could be a promising and rational approach to combat cancer.
Goutam Chakraborty +4 more
doaj +2 more sources
Expression of semaphorin‐3A in the joint and role in osteoarthritis
Cell Biochemistry and FunctionAbstractOsteoarthritis (OA) is characterised by the deterioration of cartilage in the joints and pain. We hypothesise that semaphorin‐3A (sema‐3A), a chemorepellent for sensory nerves, plays a role in joint degradation and pain. We used the mechanical joint loading (MJL) model of OA to investigate sema‐3A expression in the joint and examine its ...
Xiang Li +6 more
openaire +4 more sources