Results 31 to 40 of about 8,554 (168)

Cdc42 and RhoA reveal different spatio-temporal dynamics upon local stimulation with Semaphorin-3A

Frontiers in Cellular Neuroscience, 2015
Small RhoGTPases, such as Cdc42 and RhoA, are key players in integrating external cues and intracellular signaling pathways that regulate growth cone (GC) motility.
Federico eIseppon, Luisa Maria Rosaria Napolitano, Luisa Maria Rosaria Napolitano, Vincent eTorre, Dan eCojoc   +4 more
doaj   +1 more source

Structure of the Plexin Ectodomain Bound by Semaphorin-Mimicking Antibodies. [PDF]

PLoS ONE, 2016
Semaphorin family proteins act on cells to mediate both repulsive and attractive guidance via binding to plexin family receptors, thereby playing fundamental roles in the morphogenesis and homeostasis of various tissues.
Kei Suzuki, Hiroyuki Tsunoda, Ryusuke Omiya, Kyoko Matoba, Takeshi Baba, Sachiyo Suzuki, Hiroaki Segawa, Atsushi Kumanogoh, Kenji Iwasaki, Kunihiro Hattori, Junichi Takagi   +10 more
doaj   +1 more source

Structure of the Semaphorin-3A Receptor Binding Module [PDF]

Neuron, 2003
The semaphorins are a large group of extracellular proteins involved in a variety of processes during development, including neuronal migration and axon guidance. Their distinctive feature is a conserved 500 amino acid semaphorin domain, a ligand-receptor interaction module also present in plexins and scatter-factor receptors.
Antipenko, Alexander, Himanen, Juha-Pekka, van Leyen, Klaus, Nardi-Dei, Vincenzo, Lesniak, Jacob, Barton, William A., Rajashankar, Kanagalaghatta R., Lu, Min, Hoemme, Claudia, Püschel, Andreas W., Nikolov, Dimitar B.   +10 more
openaire   +2 more sources

SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome.

PLoS Genetics, 2012
Kallmann syndrome (KS) associates congenital hypogonadism due to gonadotropin-releasing hormone (GnRH) deficiency and anosmia. The genetics of KS involves various modes of transmission, including oligogenic inheritance.
Naresh Kumar Hanchate, Paolo Giacobini, Pierre Lhuillier, Jyoti Parkash, Cécile Espy, Corinne Fouveaut, Chrystel Leroy, Stéphanie Baron, Céline Campagne, Charlotte Vanacker, Francis Collier, Corinne Cruaud, Vincent Meyer, Alfons García-Piñero, Didier Dewailly, Christine Cortet-Rudelli, Ksenija Gersak, Chantal Metz, Gérard Chabrier, Michel Pugeat, Jacques Young, Jean-Pierre Hardelin, Vincent Prevot, Catherine Dodé   +23 more
doaj   +1 more source

Inflammatory Semaphorins in the Pathogenesis and Prognosis of Acute Ischemic Stroke

Medicina
Background and Objectives: Semaphorins are immunoregulatory proteins involved in inflammation and neurovascular modulation. Their roles in ischemic stroke pathogenesis and prognosis have recently gained attention.
Esen Çiçekli, Dilcan Kotan, Levent Avcı   +2 more
doaj   +1 more source

Semaphorins and Their Receptors in Hematological Malignancies

Frontiers in Oncology, 2019
While semaphorins were initially identified as axonal guidance cues for wiring the neural network, it was then recognized their wide relevance in tissue development and homeostasis.
Li Wei, Hongbo Li, Luca Tamagnone, Luca Tamagnone, Hua You, Hua You, Hua You   +6 more
doaj   +1 more source

Secreted human amyloid precursor protein binds semaphorin 3a and prevents semaphorin-induced growth cone collapse. [PDF]

PLoS ONE, 2011
The amyloid precursor protein (APP) is well known for giving rise to the amyloid-β peptide and for its role in Alzheimer's disease. Much less is known, however, on the physiological roles of APP in the development and plasticity of the central nervous ...
Margaret H Magdesian, Matthias Gralle, Luiz H Guerreiro, Paulo José I Beltrão, Milena M V F Carvalho, Luís Eduardo da S Santos, Fernando G de Mello, Ricardo A M Reis, Sérgio T Ferreira   +8 more
doaj   +1 more source

Assessment of Serum Semaphorin-3A Level in Systemic Lupus Erythematosus Patients in Suez Canal Region

Indian Journal of Rheumatology, 2022
Background: Semaphorin-3A (Sema-3A) is an important immunoregulator protein; it has a role in the maintenance of self-tolerance, so it is thought to be involved in the pathogenesis of many autoimmune diseases such as systemic lupus erythematosus (SLE ...
Alaa Saber Shams, Nevene Ramsis Wissa, Mai Mohamed Abdelnaby, Rania M Saleh   +3 more
doaj   +1 more source

Lentiviral Mediated Expression of Soluble Neuropilin 1 Inhibits Semaphorin 3A-mediated Collapse Activity in Vitro

Basic and Clinical Neuroscience, 2021
Introduction: Semaphorin 3A (Sema 3A) is a secreted protein, which plays an integral part in developing the nervous system. It has collapse activity on the growth cone of dorsal root ganglia.
Keivan Nedaei, Mahdi Hesaraki, Saeideh Mazloomzadeh, Mehdi Totonchi, Ali Reza Biglari   +4 more
doaj  

Identifying a Csmd3+ Microglial Subpopulation that Drives Cold‐to‐Hot Transition and Immune‐Cure in Glioblastoma

Advanced Science, EarlyView.
The study establishes an immune‐cure (ICu) mouse model based on a TMEMed G422TN‐GBM system that faithfully recapitulates human TMEMed GBM. scRNA‐seq analysis reveals a Csmd3+ microglial subset with innate immune memory (IIM) potential that potently suppresses GBM growth, drives a TME cold‐to‐hot transition, and induces 100% ICu in long‐term survival ...
Hai‐Feng Jiang, Pan‐Pan Gao, Yu‐Wen Du, Li‐Qin Wu, En‐Zhi Yin, Qi An, Ze‐Hua Ding, Jin‐Wen Shi, Ya Shu, Ruoqiao Chen, Feng Liu, Mingfeng Li, Xiao Qian Chen   +12 more
wiley   +1 more source