Results 21 to 30 of about 117,092 (200)
Autoimmunity, 2019 Background: Semaphorin-3A (Sema3A) and Semaphorin-7A (Sema7A) play crucial roles in immune system by inhibiting T cell proliferation and leading to the secretion of pro-inflammatory cytokines.
Li-Na Liu, Peng Wang, Yan-Feng Zou
exaly +2 more sources
Basic and Clinical Neuroscience, 2021 Introduction: Semaphorin 3A (Sema 3A) is a secreted protein, which plays an integral part in developing the nervous system. It has collapse activity on the growth cone of dorsal root ganglia.
Keivan Nedaei +4 more
doaj +1 more source
The Chemorepulsive Protein Semaphorin 3A and Perineuronal Net-Mediated Plasticity [PDF]
Neural Plasticity, 2016 During postnatal development, closure of critical periods coincides with the appearance of extracellular matrix structures, called perineuronal nets (PNN), around various neuronal populations throughout the brain.
F. de Winter +5 more
doaj +7 more sources
Expression of semaphorin-3A in the joint and role in osteoarthritis.
Cell Biochemistry and FunctionOsteoarthritis (OA) is characterised by the deterioration of cartilage in the joints and pain. We hypothesise that semaphorin-3A (sema-3A), a chemorepellent for sensory nerves, plays a role in joint degradation and pain.
Poulet, B +13 more
core +3 more sources
The role of semaphorin 3A on chondrogenic differentiation. [PDF]
In Vitro Cell Dev Biol AnimAbstractOsteoblast-derived semaphorin3A (Sema3A) has been reported to be involved in bone protection, and Sema3A knockout mice have been reported to exhibit chondrodysplasia. From these reports, Sema3A is considered to be involved in chondrogenic differentiation and skeletal formation, but there are many unclear points about its function and mechanism ...
Tsuboi E +10 more
europepmc +3 more sources
Semaphorin 3A in the Immune System: Twenty Years of Study. [PDF]
Biochemistry (Mosc), 2022 Semaphorin 3A is a secreted glycoprotein, which was originally identified as axon guidance factor in the neuronal system, but it also possesses immunoregulatory properties. Here, the effect of semaphorin 3A on T-lymphocytes, myeloid dendritic cells and macrophages is systematically analyzed on the bases of all publications available in the literature ...
Kiseleva EP, Rutto KV.
europepmc +3 more sources
A Potential Role of Semaphorin 3A during Orthodontic Tooth Movement. [PDF]
Int J Mol Sci, 2021 Background: Induced tooth movement during orthodontic therapy requires mechano-induced bone remodeling. Besides various cytokines and growth-factors, neuronal guidance molecules gained attention for their roles in bone homeostasis and thus, potential ...
Şen S, Lux CJ, Erber R.
europepmc +2 more sources
Activity-induced secretion of semaphorin 3A mediates learning. [PDF]
Eur J Neurosci, 2021 Abstract The semaphorin family is a well‐characterized family of secreted or membrane‐bound proteins that are involved in activity‐independent neurodevelopmental processes, such as axon guidance, cell migration, and immune functions. Although semaphorins have recently been demonstrated to regulate activity‐dependent synaptic scaling ...
Jitsuki-Takahashi A +9 more
europepmc +4 more sources
Semaphorins in Adult Nervous System Plasticity and Disease
Frontiers in Synaptic Neuroscience, 2021 Semaphorins, originally discovered as guidance cues for developing axons, are involved in many processes that shape the nervous system during development, from neuronal proliferation and migration to neuritogenesis and synapse formation.
Daniela Carulli +3 more
doaj +1 more source
The Role of Semaphorin 3A in Bone Remodeling [PDF]
Frontiers in Cellular Neuroscience, 2017 Bone remodeling occurs at the bone surface throughout adult life and associates bony quantity and quality. This process is a balance between the osteoblastic bone formation and osteoclastic bone resorption, which cross-talks together. Semaphorin 3A is a membrane-associated secreted protein and regarded as a diffusible axonal chemorepellent, which has ...
Li, Zhenxia +8 more
openaire +2 more sources