Results 41 to 50 of about 117,092 (200)

SEMA3A, a gene involved in axonal pathfinding, is mutated in patients with Kallmann syndrome.

PLoS Genetics, 2012
Kallmann syndrome (KS) associates congenital hypogonadism due to gonadotropin-releasing hormone (GnRH) deficiency and anosmia. The genetics of KS involves various modes of transmission, including oligogenic inheritance.
Naresh Kumar Hanchate, Paolo Giacobini, Pierre Lhuillier, Jyoti Parkash, Cécile Espy, Corinne Fouveaut, Chrystel Leroy, Stéphanie Baron, Céline Campagne, Charlotte Vanacker, Francis Collier, Corinne Cruaud, Vincent Meyer, Alfons García-Piñero, Didier Dewailly, Christine Cortet-Rudelli, Ksenija Gersak, Chantal Metz, Gérard Chabrier, Michel Pugeat, Jacques Young, Jean-Pierre Hardelin, Vincent Prevot, Catherine Dodé   +23 more
doaj   +1 more source

{alpha}2-Chimaerin, cyclin-dependent kinase 5/p35, and its target collapsin response mediator protein-2 are essential components in semaphorin 3A-induced growth-cone collapse

, 2004
Neurite outgrowth is influenced by positive and negative signals that include the semaphorins, an important family of axonal outgrowth inhibitors. Here we report that the Rac GTPase activating protein (GAP){alpha}2-chimaerin is involved in Semaphorin 3A (
Eickholt, B, Teo, M, Lim, L, Ferrari, G, Eickholt, Britta, Jacobs, Tom, Leung, Thomas, Jacobs, T., Leung, T., Leung, T, Eickholt, B., Lim, L., Hall, Christine, Qi, R Z, Teo, M., Monfries, C, Jacobs, T, Brown, Matthew, Monfries, Clinton, Teo, Mabel, Qi, Robert Z., Ferrari, G., Qi, R.Z., Lim, Louis, Brown, M., Hall, C., Ferrari, Giovanna, Hall, C, Brown, M, Monfries, C.   +29 more
core   +1 more source

The Response of Chick Retinal Ganglion Cells to Semaphorin 3A: potential Semaphorin 3A receptors and effects of BDNF and CNTF

, 2022
In the developing nervous system, axons are guided towards their targets by guidance cues. The guidance molecule Semaphorin 3A is a repulsive axon guidance molecule for many axons.
Hermanova, Eva
core  

Autocrine semaphorin 3A signaling promotes glioblastoma dispersal [PDF]

Oncogene, 2009
Glioblastoma multiforme (GBM) is the most malignant glioma type with diffuse borders due to extensive tumor cell infiltration. Therefore, understanding the mechanism of GBM cell dispersal is critical for developing effective therapies to limit infiltration.
T, Bagci, J K, Wu, R, Pfannl, L L, Ilag, D G, Jay   +4 more
openaire   +2 more sources

Inflammatory Semaphorins in the Pathogenesis and Prognosis of Acute Ischemic Stroke

Medicina
Background and Objectives: Semaphorins are immunoregulatory proteins involved in inflammation and neurovascular modulation. Their roles in ischemic stroke pathogenesis and prognosis have recently gained attention.
Esen Çiçekli, Dilcan Kotan, Levent Avcı   +2 more
doaj   +1 more source

Semaphorins and Their Receptors in Hematological Malignancies

Frontiers in Oncology, 2019
While semaphorins were initially identified as axonal guidance cues for wiring the neural network, it was then recognized their wide relevance in tissue development and homeostasis.
Li Wei, Hongbo Li, Luca Tamagnone, Luca Tamagnone, Hua You, Hua You, Hua You   +6 more
doaj   +1 more source

Semaphorin-3A, semaphorin-7A gene single nucleotide polymorphisms, and systemic lupus erythematosus susceptibility

, 2019
Background: Semaphorin-3A (Sema3A) and Semaphorin-7A (Sema7A) play crucial roles in immune system by inhibiting T cell proliferation and leading to the secretion of pro-inflammatory cytokines.
Hai-Feng Pan (112460), Yan-Feng Zou (835100), Yuzhou Zhang (261075), Jian Cheng (48763), Li-Na Liu (418572), Wenbiao Hu (16913), Peng Wang (34436), Zhiwei Xu (294494)   +7 more
core   +1 more source

Semaphorin 3A Is Required for Guidance of Olfactory Axons in Mice [PDF]

The Journal of Neuroscience, 2000
Semaphorin 3A (Sema3A) is a membrane-associated secreted protein that has chemorepulsive properties for neuropilin-1 (npn-1)- expressing axons. Although mice lacking the Sema3A protein display skeletal abnormalities and heart defects, most axonal projections in the CNS develop normally.
G A, Schwarting, C, Kostek, N, Ahmad, C, Dibble, L, Pays, A W, Püschel   +5 more
openaire   +2 more sources

Secreted human amyloid precursor protein binds semaphorin 3a and prevents semaphorin-induced growth cone collapse. [PDF]

PLoS ONE, 2011
The amyloid precursor protein (APP) is well known for giving rise to the amyloid-β peptide and for its role in Alzheimer's disease. Much less is known, however, on the physiological roles of APP in the development and plasticity of the central nervous ...
Margaret H Magdesian, Matthias Gralle, Luiz H Guerreiro, Paulo José I Beltrão, Milena M V F Carvalho, Luís Eduardo da S Santos, Fernando G de Mello, Ricardo A M Reis, Sérgio T Ferreira   +8 more
doaj   +1 more source

Assessment of Serum Semaphorin-3A Level in Systemic Lupus Erythematosus Patients in Suez Canal Region

Indian Journal of Rheumatology, 2022
Background: Semaphorin-3A (Sema-3A) is an important immunoregulator protein; it has a role in the maintenance of self-tolerance, so it is thought to be involved in the pathogenesis of many autoimmune diseases such as systemic lupus erythematosus (SLE ...
Alaa Saber Shams, Nevene Ramsis Wissa, Mai Mohamed Abdelnaby, Rania M Saleh   +3 more
doaj   +1 more source